Check out my poster today at #BPS2026! We developed a Rho GTPase single-molecule biosensors for live cell imaging.

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?

Excited to share our latest work in @science.org on a new small polymerase.
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🚨🚨Double preprint alert! 🚨🚨
Two papers went up on Biorxiv this week!
The first presents new chemigenetic FRET-based biosensors: www.biorxiv.org/content/10.6...
And the second presents an improved version of our C-Y FRET PKA reporters, AKAR6 www.biorxiv.org/content/10.6...
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Not something you see in textbooks very often: tripolar mitosis.

Funny moment in grant writing

Dealing with ScienCV Formatting YouTube video by Kevin Bonham

Struggling with new NIH biosketch because they only support HMTL instead of markdown? I just saw a short YouTube tutorial from Kevin Bonham that give you some quick tricks: m.youtube.com/watch?v=0Tjt...

Structure of riboflavine

Periodic reminder that the fluorescent compound in mammalian cell culture media, such as DMEM, is riboflavin (not phenol red)

Huntington's disease successfully treated for first time One of the most devastating diseases finally has a treatment that can slow its progression and transform lives, tearful doctors tell BBC.

Awesome news!

www.bbc.com/news/article...

😥💔

Next gen Rhodamine dye?

Spent some time building a customized dual view system in the lab. Adopted a Y-shape path to allow focus adjustment and fit in enough space on the air table. Fun experience!

How to design a chalk talk—the million dollar sales pitch | Molecular Biology of the Cell Each faculty recruiting season, many postdocs ask, “What is a chalk talk?” The chalk talk is many things—a sales pitch, a teaching demonstration, a barrage of questions, and a description of a future ...

This is the time of year many scientists are going on the academic job market. I try to provide some guidance on chalk talks in this essay. Please share. www.molbiolcell.org/doi/full/10....

Klaus Hahn has some classic movies of manually directing migration: tinyurl.com/49ftza3h. The Weiner lab use HL60 (v fast) continually illuminating one side: tinyurl.com/mryvy9m7 . Here is an example of our automatic guidance of HT1080 (slower) to specific paths, look out for a bioRxiv upload soon!🌀

insane story and another reason american healthcare is broken.

so sorry for your loss, Daniel