Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder This study describes the cell-type-specific lysosomal proteome across the major brain cell types and identifies SLC45A1 as a neuron-specific lysosomal sugar exporter linked to lysosomal storage disease.

Now online! Cell-type resolved protein atlas of brain lysosomes identifies SLC45A1-associated disease as a lysosomal disorder

It was a great privilege to present our work on #extracellularvesicles and #T1D at the Human Islet Research Network Annual Meeting

🧵(5/5) Together, this work opens a path toward minimally invasive biomarkers of neuroinflammation. Excited to apply these tools in different neurodegenerative diseases and patient studies. ✨

🧵(4/5) miR-146a-5p emerges as a consistent marker of pro-inflammatory activation across mouse + human iPSC microglia 🧫 and is detectable in microglial EVs during acute neuroinflammation.

🧵(3/5) Using our new ExoMap1 mouse 🐁 , we detect microglia-derived EVs in plasma for the first time. This lets us directly track CNS-derived vesicles in vivo.

🧵(2/5) First We find that microglia release EVs and non-vesicular particles with distinct α2,6-sialylation and small RNA signatures 🧬that change with their activation state.

🧵(1/5) Neuroinflammation drives many neurological diseases 🧠, but we still lack good non-invasive biomarkers. We asked: can microglia send detectable signals into the bloodstream🩸?

State-dependent release of extracellular particles with distinct α2,6-sialylation patterns and small RNA cargo related to neuroinflammation Neuroinflammation is a significant contributor to neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, and related dementias; yet peripheral biomarkers for neuroinflammation...

🚨Our new preprint is out!

We reveal that #microglia release particles (#extracellularvesicles #exomeres #supermeres)with distinct α2,6-sialylation signatures and small RNA cargo depending on their state🧠✨

Check it out👇

🔗 www.biorxiv.org/content/10.1...

🧠 The Lipid #Brain Atlas is out now! If you think #lipids are boring and membranes are all the same, prepare to be surprised. Led by @lucafusarbassini.bsky.social with Giovanni D'Angelo's lab, we mapped membrane lipids in the mouse brain at high resolution.
www.biorxiv.org/cgi/content/...

I’m incredibly proud to share that I’ve been promoted to #Instructor!

I want to thank everyone who has supported me along the way-mentors who believed in me, colleagues and friends who stood by me, and my family who have always been my foundation. I wouldn’t be here without you!

@Quartzy #LABAPALOOZA2025 was amazing! 🎉Learned practical lab strategies, got inspired by industry leaders-plus I earned my Admin Certification, and made great connections. Can’t wait for the next one! 🙌🔬 #Quartzy #LabLife #Science

I had an amazing time at the 10-year Human #Islet Research Network Symposium! The talks were incredibly inspiring, and the insights were invaluable. It was great to catch up with all my colleagues and connect with so many new amazing colleagues @HIRN_CC @NIDDKgov #T1D #diabetes

Could you please include me 😁

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease - Nature Neuroscience Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in Alzheimer’s disease, shining l...

Tau filaments are tethered within brain extracellular vesicles in Alzheimer’s disease
www.nature.com/articles/s41...

Could I please be included? 🙋🏻‍♀️😊

The newest (and furriest!) member of @AAEV_org had a tail-wagging blast in Houston last week! 🐾 Inspiring talks and exciting science 🧪🧫🧬#AAEV
#extracellularvesicles #exosomes

Ep09 (Nov 2024): rEView Insights - David Freedman and George Daaboul The rEView Podcast · Episode

This week #rEView is featuring the last #podcast in the series leading up to #ISEVxTech!

David Freedman and George Daaboul are co-founders of Everest Biolabs, specialising in workflows for #ExtracellularVesicles isolation and characterisation.

open.spotify.com/episode/3UBG...

Done 😊

Could you please include me ? 😊🙋🏻‍♀️

Starter pack for #Type1Diabetes and #Islet Research

Comment if you want to be added to the list 👇

Could you please include me!? 😊

Could you please include me? 😊

Would love to join 🙋🏻‍♀️😊

Would love to join 🙋🏻‍♀️😊

Would love to join

Would love to join 🙋🏻‍♀️

Me 🙋🏻‍♀️😊

Last week, I had the incredible honor of presenting my research on #microglia #extracellularvesicles and #nonvesicularextracellularnanoparticles at #AAEV ! Sharing insights and connecting with experts in the field was truly inspiring! @AAEV_org

some great starter packs for the #glia, #astrocyte, #oligodendrocyte, #microglia, #neuro researcher: gliasky, astrocytesky, microglia
But if you also like interactions between celltypes, please help this starter pack get started. Maybe someone can connect all of us in a feed?

go.bsky.app/MHtJzeC

Me 🙋🏻‍♀️😊