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Posts by Theoretical Biology & Bioinformatics @ UU

Vacant Positions - JSMC Jena School for Microbial Communication

The VEO Group has a position open for a PhD student to investigate Fungi-bacteria interactions in complex communities! Check out this position and many more at the JSMC website 👇👇

www.jsmc-phd.de/admission/va...

3 weeks ago 6 7 0 0
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PhD Position in Computational Modelling of Fungal Evolution How do giant mobile elements called ‘Starships’ reshape fungal plant pathogens? Help us computationally model their spread and impact in nature and agriculture!

Phd Position alert 🚨

Join our project ASTRAfun (Adaptation and Starship Traffic in Root-Associated fungi), in which we will use computational models to unveil the hidden dynamics of fungal evolution.

It’s not going to be just regular fun. It’s going to ASTRAfun. 🤓

www.uu.nl/en/organisat...

4 weeks ago 24 28 1 4
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In case you missed it: our review titled "Spatial structure: shaping the ecology and evolution of microbial communities" is out! 🚨

Let me hit you with some highlights on why spatial structure matters. (and why you should care!)

Sharing is appreciated 🙏 🧵👇

doi.org/10.1093/fems...

1 month ago 145 89 3 2

Space is the place (for microbes 🦠)!
Delighted to have contributed to this review on spatial structure in microbial communities by @marcelbaecker.bsky.social @simonvanvliet.bsky.social @bedutilh.bsky.social @bramvandijk.bsky.social and others.

2 months ago 9 2 0 0
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The LECA had a conventional kinetochore and the kinetoplastid kinetochore is a derived feature – a critical evaluation of Akiyoshi, 2025 Summary:Akiyoshi, 2025 presented a hypothesis with implications for the early evolution of eukaryotes and eukaryotic cell division machinery. In this Correspondence, the authors conclude that this hyp...

Recently, a Hypothesis was posed in @jcellsci.bsky.social in which the root of eukaryotes was placed between kinetoplastids and all other eukaryotes. From this, it was implied that LECA did not have a kinetochore. We argue this is highly unlikely. A 🧵(1/12)

Read our reply here: tinyurl.com/n87myhpr

2 months ago 32 18 2 3

Please check out our review on the impact of spatial structure in microbial ecosystems! In it, we discuss how spatial patterns impact microbial ecology and evolution, eventually impacting everything we see around us!

See @marcelbaecker.bsky.social's amazing summary below :)

🦠 𝚂𝙿𝙰𝙲𝙴 𝙼𝙰𝚃𝚃𝙴𝚁𝚂 ! 🦠

2 months ago 18 4 1 0

Everyone knows that space and spatial structure is super important in shaping the Microverse 🌎🌍🌏 Check out this amazing review where @marcelbaecker.bsky.social and @bramvandijk.bsky.social et al bring together a huge body of knowledge @microverse.bsky.social @binfutrecht.bsky.social

2 months ago 15 8 0 0
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PhD student bioinformatics: Viral strategies in the global Microverse

We have an open position for a bioinformatics/theoretical microbial ecology PhD student to study viral strategies in the global Microverse! Join us at the @microverse.bsky.social at @uni-jena.de, please apply through this link:
jobs.uni-jena.de/jobposting/9...

2 months ago 21 30 0 0
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Spatial structure: shaping the ecology and evolution of microbial communities Spatial structure naturally emerges in microbial communities, shaping growth, interactions, and evolution, and revealing how microscale processes scale up

Wrapping up a productive week: very glad to have contributed to this review on how spatial structure shapes microbial ecology and evolution, led by @marcelbaecker.bsky.social, @bedutilh.bsky.social, @bramvandijk.bsky.social and many others. doi.org/10.1093/fems...

2 months ago 39 15 3 2

@bramvandijk.bsky.social (and many other)'s new paper covered insights in microbial ecology, evolution and theoretical biology.

2 months ago 7 3 0 0
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Welcome to Bluesky, @pieterhart.bsky.social!

Pieter just joined my group as a PhD student studying bacterial genome evolution—exciting years ahead!

Here he is enjoying a chat about his MSc work (w/ @kassipan.bsky.social & @ettema.bsky.social) at Science4Life @utrechtuniversity.bsky.social 🧬🦠✨

4 months ago 23 4 2 0

Now officially published in Current Biology 🥳🥳 @mfseidl.bsky.social @binfutrecht.bsky.social

www.cell.com/current-biol...

4 months ago 64 37 3 0

New preprint from our lab! Led by Emine Ali and @maxraas.bsky.social

See the highlights below!

4 months ago 6 1 0 0

Our story on the kinetochore composition of the ciliate Tetrahymena thermophila is out now on bioRxiv! We find surprisingly many orthologs of conventional kinetochore components, but also components that have very different evolutionary origins. A 🧵 (1/11)

Check it out here: tinyurl.com/4ectm9x4

4 months ago 25 10 2 2

Now out in @currentbiology.bsky.social !

Screening over a thousand fungal genomes, @jromeijn.bsky.social, Iñigo Bañales Belaunde and @mfseidl.bsky.social find that horizontal transfer shapes the fungal mobilome
🍄🔄✈️🧬

@ubc-uu.bsky.social

Don't miss Josje's thread for a summary of the findings! 👇

4 months ago 9 4 0 0
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In this approach, the defective virus competes with the normal virus for shared proteins, which suppresses viral replication.

Using mathematical modeling, they found that while this treatment is promising, a protective immune response drastically reduces its effectiveness.

#mathbio
#immunobio

4 months ago 4 0 0 0
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Immune responses may make HIV-1 therapeutic interfering particles less effective The current standard treatment for HIV-1 infection is antiretroviral therapy, which effectively suppresses viral replication but requires a lifelong d…

Fighting virus with…virus?

In a new paper, Griffin Kutler Dodd and Rob de Boer investigated whether defective virus particles could be used to treat HIV-1 infection.

@ubc-uu.bsky.social @utrechtuniversity.bsky.social

Now out at Journal of Theoretical Biology
www.sciencedirect.com/science/arti...

4 months ago 6 0 1 0

MetaPointFinder:
A new approach for detecting mutation-driven antimicrobial resistance directly from metagenomic reads.
Fills a major gap in current resistome profiling by capturing chromosomal AMR mutations that metagenome tools miss.

github.com/aldertzomer/...

4 months ago 24 19 3 1
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Extensive horizontal transfer of transposable elements shapes fungal mobilomes Romeijn et al. reveal that horizontal transposon transfer is widespread in fungi, contributing up to 70% of transposon content in some taxa. The authors uncover thousands of events across diverse line...

Extensive horizontal transfer of transposable elements shapes fungal mobilomes

@currentbiology.bsky.social by @jromeijn.bsky.social et al from @mfseidl.bsky.social

www.cell.com/current-biol...

4 months ago 69 31 0 1

The mystery deepens: how did all complex life on Earth originate? In this intriguing VPRO Tegenlicht episode (in Dutch), PhD student Max Raas from the @kopslab.bsky.social talks about his collaboration with Berend Snel. They study the evolution of cell division machinery in single-celled organisms.

5 months ago 7 4 0 0

Wonderful news for our team!

Congratulations to Daniel on receiving this award, and looking forward to more archaeal research in our unit! 🦠 💻 📊 🧑‍🔬

@utrechtuniversity.bsky.social @ubc-uu.bsky.social

5 months ago 9 2 0 0

New review, result of a collaboration between researchers at @binfutrecht.bsky.social and Uni Groningen.

How do plant development and morphology mediate resource acquisition and costs?
🌿🌳🌺 💰💵📈

academic.oup.com/jxb/advance-...

5 months ago 1 1 0 0

Featuring Paulien Hogeweg (2nd from the right), founder and lifelong colleague at @binfutrecht.bsky.social @utrechtuniversity.bsky.social

Very well deserved, Paulien!

5 months ago 6 2 1 0
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Bram van Dijk @bramvandijk.bsky.social (@utrechtuniversity.bsky.social): How mobile genes reshape the microbial arms race
#NIME2025

6 months ago 13 3 2 0
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Yesterday the @biosb.bsky.social and Netherlands Integrative Microbial Ecology initiative organised a symposium on #MicrobialEcology. We hosted 80+ researchers, with 10 talks and 10 posters at @utrechtuniversity.bsky.social. A beautiful chance to hear more about exciting research across the country!

6 months ago 13 2 1 1

Very nice documentary about the origins of complex life with my PhD advisor Berend Snel @binfutrecht.bsky.social!

6 months ago 12 7 0 0
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Using this methodology, they recovered both known and many novel QTLs for color and height, opening up new breeding targets.

This study represents a blueprint for high-throughput genetics studies, with the entire methodology as well as all the raw data fully and conveniently available.

7 months ago 1 0 0 0
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They used an innovative GWAS approach involving the construction of many traits as ratios of the imaging data and quantifying these traits using various summary statistics. They then optimized the GWAS for computational efficiency to facilitate mapping this large number of traits.

7 months ago 1 0 1 0
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From aerial drone to quantitative trait locus: leveraging next‐generation phenotyping to reveal the genetics of color and height in field‐grown Lactuca sativa Understanding the genetic basis of lettuce color is important because these traits correlate with metabolites such as anthocyanins, which are known to have strong antioxidant properties. Furthermore,....

Check out the latest paper by the Snoek lab in @theplantjournal.bsky.social, a genetics study involving a large field trial with 200 lettuce genotypes phenotyped by a drone.

Great work by Rens Dijkhuizen, Bram van Eijnatten, Sarah Mehrem, @guidopmi.bsky.social & others!
doi.org/10.1111/tpj....

7 months ago 4 1 1 0