結構いい感じのデータがでてきて順調にいきそうだ！

0.33g mitigates muscle atrophy while 0.67g preserves muscle function and myofiber type composition in mice during spaceflight Spaceflight tests reveal that 0.33g mitigates muscle loss, but 0.67g is needed to keep function, impacting future Mars missions.

0.33g mitigates muscle atrophy while 0.67g preserves muscle function and myofiber type composition in mice during spaceflight | Science Advances www.science.org/doi/10.1126/...

New bioRxiv preprint from Pascal Maire’s group is out! I’m happy to have made a small contribution and to be included as a co-author.
“c-MAF transduces motor neuron firing to sustain fast-glycolytic myofibers and neuromuscular junctions” www.biorxiv.org/content/10.6...
#myoblue

Transcriptional control of myofiber type: large Maf transcription factors as principal fast myofiber regulators Sarcopenia, the progressive loss of skeletal muscle mass and function with aging, is a major challenge to healthy longevity due to its profound effect …

Our mini-review on large Maf transcription factors—the principal regulators of fast-twitch myofibers that we identified—has just been published.
www.jstage.jst.go.jp/article/trs/...

Excited to share our new paper in Skeletal Muscle! We show that large Maf transcription factors can robustly induce MYH4, normally silent in humans.
In human muscle, Mafa and Maf expression correlate with fast fiber content. #myoblue

rdcu.be/ex0un

The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases | American Journal of Physiology-Cell Physiology | American Physiological Society Myogenic regulatory factors, including myoblast determination protein 1 (MyoD1 or MyoD) and myogenic factor 5 (Myf5), crucially regulate skeletal muscle lineage specification and development. Although...

Our new review, “The Multifaceted Role of MyoD in Adult Skeletal Muscle: Homeostasis, Regeneration, and Diseases,” is now available online in AJP Cell Physiol.
journals.physiology.org/doi/abs/10.1...
@myoblue.bsky.social

Frontiers | Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma

Myogenesis gone awry: the role of developmental pathways in rhabdomyosarcoma
www.frontiersin.org/journals/cel...

Our work provides the exciting possibility of reintroducing fast-glycolytic type IIb myofibers—long absent in humans—through the manipulation of large MAFs!!
I’d like to thank Dr. Pascal Maire and Dr. Stefano Schiaffino for their invaluable comments on our study prior to submission.

Moreover, collaboration with Ildus
@SportsGenomics
RNA-seq analysis of human muscle biopsies revealed a nice positive correlation between MAFA, MAF, and MYH4 expression, with these genes elevated in power-trained individuals.

Interestingly, type IIb myofibers are largely absent in the skeletal muscles of humans, despite their significant role in smaller animals such as mice. However, large MAF can reawaken evolutionarily dormant fast-glycolytic Type IIb myofibers in human skeletal muscle.

Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle Small mammals rely on type IIb myofibers, expressing the fastest myosin IIb (encoded by MYH4 ), for rapid muscle contraction. In contrast, larger mammals, including humans, show reduced or absent MYH4...

Building upon our previous study published in Cell Rep (10.1016/j.celrep.2023.112289), which identified large Mafs as essential regulators of type IIb myofiber specification in mice, this work extends our understanding to humans. biorxiv.org/cgi/content/...
#Myotwitter