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Posts by Andreas Peschel

Tomorrow is the last day to submit an abstract for @keystonesymposia.bsky.social meeting Beyond Antibiotics: Emerging Strategies Combating Bacterial Infections.

It is going to be an amazing meeting and we have a few slots left!
keysym.us/KSBeyondAntibiotics26 #KSBeyondAntibiotics26

1 week ago 5 6 1 0
A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes | mBio Streptococcus pyogenes is a major human pathogen, responsible for diverse clinical manifestations of both superficial and invasive infections, and can lead to post-infection sequelae like rheumatic heart disease, whose prevalence on a global scale rivals that of the most serious pathogens. Invasive S. pyogenes infections are currently on the rise worldwide, notably correlating with increasing pediatric cases of scarlet fever and enhancing the concern for long-term complications. There is much that remains unknown about S. pyogenes virulence and pathogenicity, and studies focused on understanding basic systems regulating virulence factors could lead to better therapeutics and translational research. We show here one such example, where a bacterial communication system regulating a virulence mechanism relevant to in vivo infection confers the ability to alter the host’s innate immune response. We find that modifications to the cell wall arise when this virulence system is activated, which has a direct role in host-pathogen interactions. Further research into this system could provide a mechanism for disruption and serve to treat S. pyogenes infection.

A teichoic acid-like wall modification associated with immune suppression is socially regulated in Streptococcus pyogenes | mBio journals.asm.org/doi/10.1128/...

1 week ago 8 2 0 0
Advancing microbiology through foundational science - Nature Microbiology Microorganisms have tremendous potential to impact humanity, but such revelations are only possible in the light of foundational, discovery-based microbiology research.

"Research is often described as ‘basic’, but there is nothing basic about it. The links between discovery-based research and downstream applications aren’t always clear at the outset. Although a translational output may require years to achieve"

www.nature.com/articles/s41...

1 week ago 7 5 1 0
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Planetary microbiome structure and generalist-driven gene flow across disparate habitats A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological boundaries to mediate gene flow across disparate habitats, including the dissemination of antimicrobial resistance.

Planetary microbiome structure and generalist-driven gene flow across disparate habitats: Cell www.cell.com/cell/fulltex...

1 week ago 10 3 0 0
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Frontiers | First genome sequence and functional profiling of Psychrobacter SC65A.3 preserved in 5,000-year-old cave ice: insights into ancient resistome, antimicrobial potential, and enzymatic activi... IntroductionAncient cryospheric environments may preserve overlooked reservoirs of antimicrobial resistance (AMR) and bioactive potential. This study reports...

Genome sequence of a 5,000 year old bacterium (Psychrobacter) from cave ice contains more than 100 genes associated with antimicrobial resistance 😳

www.frontiersin.org/journals/mic...

2 weeks ago 18 9 1 2
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My first self-made Sorbian egg got a special design. Phagetastic Easter everyone!

2 weeks ago 7 2 0 0
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Polygenic, cell-envelope adaptations drive high-frequency daptomycin resistance in Staphylococcus capitis NRCS-A from neonatal sepsis and NEC | Antimicrobial Agents and Chemotherapy The increasing incidence of bloodstream infections caused by multi-resistant bacteria presents a major global health burden, complicating the treatment of patients facing sepsis and resulting in incre...

The NRCS-A clone of Staph. capitis is a major cause of neonatal sepsis. Worryingly, isolates are often daptomycin-resistant! Glad to contribute to Chris Slavetinsky's study! @cmfi.bsky.social @dzif.bsky.social

journals.asm.org/doi/10.1128/...

3 weeks ago 6 0 0 0
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The anatomy and molecular inventory of Staphylococcus aureus abscesses Staphylococcus aureus is an opportunistic pathogen that infects practically every body site despite differences in nutritional environment, immune milieu, and mode of inoculation. S. aureus abscesses are pathophysiological structures wherein host-derived extracellular matrix and immune cells form layers surrounding a S. aureus colony. Staphylococcal abscess communities seed staphylococcal abscesses, which are associated with worse S. aureus infection outcomes. Abscesses are also an example of the host–S. aureus interface, wherein host and pathogen adaptations define the spatial and temporal features of pathogenesis as well as the outcomes of infection. This review discusses recent discoveries in abscess formation made across organ systems and highlights findings involving host and pathogen determinants of abscess formation that improve our understanding of S. aureus pathogenesis.

The anatomy and molecular inventory of Staphylococcus aureus abscesses

3 weeks ago 5 3 0 0
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Researchers, clinicians, and trainees from around the world will come together to share the latest discoveries in:

• Staphylococcus biology

• Pathogenesis and host interactions

• Epidemiology and antimicrobial resistance

• Diagnostics, prevention, and treatment

3 weeks ago 1 1 1 0
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Please Repost 🔄

Global Staphylococcus research community is heading to the Canadian Rockies!

Join the 20th International Symposium on Staphylococci and Staphylococcal Infections
📅 September 20–24, 2026

📍 Banff Centre for Arts and Creativity, Banff, Canada

#ISSSI2026
#Staphylococcus

3 weeks ago 11 18 2 1
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Congratulations Tami! Hope to meet you in La Granja

1 month ago 2 0 0 0

(bacterial) chromosome segregationists take note 👇

membrane-anchoring of the 𝘰𝘳𝘪𝘊 region to ensure proper daughter chromosome segregation after replication initiation – proposed decades ago but never substantiated... 👉now shown for 𝘚. 𝘢𝘶𝘳𝘦𝘶𝘴 by mariana pinho's lab

1 month ago 34 15 1 0
Grafik mit goldenem, geschwungenem Weg und Bäumen, Text: „Excellent – today and in the future. University of Excellence 2027–2033“.

Grafik mit goldenem, geschwungenem Weg und Bäumen, Text: „Excellent – today and in the future. University of Excellence 2027–2033“.

Grafik mit Text vor grünem Hintergrund: 

Fünf Ziele in der neuen Förderphase

Die in der vergangenen Förderphase begonnenen Projekte werden fortgeführt beziehungsweise weiterentwickelt. Dabei wird die Universität Tübingen mit den Mitteln aus der künftigen Exzellenzförderung fünf Ziele verfolgen:

Exzellenz in Forschung und Lehre
Aufbau eines integrativen und kooperativen Universitätsumfelds
Flexibilität und Anpassungsfähigkeit in einer sich schnell verändernden Welt
Globales Bewusstsein und internationale Vernetzung
Gesellschaftliches Engagement, Innovation und Ko-Kreation

Grafik mit Text vor grünem Hintergrund: Fünf Ziele in der neuen Förderphase Die in der vergangenen Förderphase begonnenen Projekte werden fortgeführt beziehungsweise weiterentwickelt. Dabei wird die Universität Tübingen mit den Mitteln aus der künftigen Exzellenzförderung fünf Ziele verfolgen: Exzellenz in Forschung und Lehre Aufbau eines integrativen und kooperativen Universitätsumfelds Flexibilität und Anpassungsfähigkeit in einer sich schnell verändernden Welt Globales Bewusstsein und internationale Vernetzung Gesellschaftliches Engagement, Innovation und Ko-Kreation

Logowand: Exzellenzstrategie, Wissenschaftsrat, DFG sowie Förderhinweis mit Logos von Bundesministerium für Forschung, Technologie und Raumfahrt und Baden-Württembergischem Wissenschaftsministerium.

Logowand: Exzellenzstrategie, Wissenschaftsrat, DFG sowie Förderhinweis mit Logos von Bundesministerium für Forschung, Technologie und Raumfahrt und Baden-Württembergischem Wissenschaftsministerium.

Die Universität Tübingen bleibt Exzellenzuniversität! 🎉 Dies hat eine Kommission aus Wissenschaftlerinnen und Wissenschaftlern sowie Vertreterinnen und Vertretern von Bund und Ländern am Abend bekannt gegeben: 👉 uni-tuebingen.de/universitaet/… #ExStra #Forschung #UniTübingen #Exzellenzstrategie

1 month ago 34 7 3 3

Our recent work is now available in bioRXIV!

1 month ago 10 5 0 0

Our work on understanding how Staphylococcus aureus mode of cell division contributes to pathogenesis is now available in bioRxiv

1 month ago 35 14 2 0

Congrats Xin, have a good start at Fudan!

1 month ago 3 0 0 0
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Cool new study in Nat Comm by Amanda Dugan, Deepsing Syangtan, et al that identifies INTELECTIN-2 as a broad-spectrum antimicrobial operating right at mucosal surfaces

INTELECTIN-2 not only senses microbes, it actively shapes which microbes gets to stay

🧵 (1/5)

@natcomms.nature.com

1 month ago 17 3 2 0

Lovely work driven by Lizzie Ledger in the group: a new but druggable mechanism by which Staphs produce biofilm using components of human serum. First polysaccharides, then protein, then eDNA, now lipids too!

bsky.app/profile/bior...

1 month ago 12 8 0 0
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Amazing resolution of this beautiful mechanism!
@spp2330.bsky.social

1 month ago 6 3 0 0

@cmfi.bsky.social continues its international conference series: come to Tübingen in 2027!

1 month ago 2 1 0 0
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Collagen binding adhesin restricts Staphylococcus aureus skin infection - Nature Communications Staphylococcus aureus is able to evade host immune responses by expressing surface adhesins, like collagen binding adhesin (Cna). Here, the authors report the role of Cna during S. aureus skin infecti...

Cool new study suggesting that some Staphs use collagen binding to evade immunity on the skin, with a substantial trade-off in terms of bacterial load and disease severity. Congrats to the authors! #microsky

1 month ago 6 4 1 0
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Skin androgens affect virulence of Staphylococcus aureus Nature Microbiology, Published online: 27 February 2026; doi:10.1038/s41564-026-02281-ySex-specific differences in susceptibility to skin infections with Staphylococcus aureus are well described. Testosterone now emerges as a direct modulator of the accessory gene regulator quorum sensing system, increasing S. aureus virulence, which both explains sex-specific differences and informs treatment strategies.

Out Now! Skin androgens affect virulence of Staphylococcus aureus #MicroSky

1 month ago 18 4 0 0

One of my favorite papers of past few years!

1 month ago 18 5 0 0
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Bacterial defense systems and host ecology drive the evolution of intra-species lineages Staphylococcus aureus lineages vary widely in the frequency of gene exchange and the diversity of genome content. Gorzynski and Harling-Lee et al. show that both host ecology and the horizontal acquis...

Great work by Jamie Gorzynski and Josh-Harling-Lee from the group providing insights into the evolutionary origins of bacterial lineages. A collaboration with @jrpenades.bsky.social @wfigueroac3.bsky.social. #Staph Cell Reports www.cell.com/cell-reports...

2 months ago 27 13 0 0
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Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.

Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...

2 months ago 30 15 0 0
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Bacterial metabolic remodeling by convergent evolution unlocks nutrient availability after a host switch Staphylococcus aureus has undergone metabolic remodeling to adapt to the dairy niche.

Cool new paper from Amy Pickering in Edinburgh comparing phenotypes in Staph between host species, highlighting a key role for proteolysis and peptide utilisation in bovine mastitis. Great work!

2 months ago 4 2 1 0
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Staphylococcus species infected by a bacteriophage with a tail that is both curved and contractile | mBio Past work has seen over-representation of Staphylococcus aureus clinical isolates in genome and biology studies on staphylococci. Here, we show by a selective plating analysis of municipal wastewater ...

🫴 Staphylococcus species infected by a bacteriophage with a tail that is both curved and contractile:

👇

| mBio journals.asm.org/doi/10.1128/...

@mbio.bsky.social @spp2330.bsky.social

2 months ago 5 3 0 0
Rapid dissemination of Staphylococcus aureus in the neonatal intensive care unit is associated with invasive infection - Nature Communications In this work, authors use whole genome tracking in a neonatal intensive care unit to reveal a strong link between Staphylococcus aureus colonization and invasive infection, pinpointing critical new ta...

Thrilled to share this study tracking Staph aureus carriage and transmission across the NICU using genomics! Work done w @pjplanet.bsky.social & @ahmedmicrobes.bsky.social and made possible by @centermicrobialmed.bsky.social.

Study co-led by the amazing @qianxuan.bsky.social & Lakshmi Srinivasan!

2 months ago 36 14 3 2

Super cool story from Sam Fenn. He developed a wound model where s. aureus & p. aerunginosa & c. albicans fight it out shows that copper is central to the outcome where Candida and pseudomonas take copper from human tissue to gang up on staph!

But staph being staph is as always one step ahead….

2 months ago 13 5 2 1
PhD position (m/f/d) for "Translation of evolutionary principles into antimicrobial treatment" PhD position (m/f/d) for "Translation of evolutionary principles into antimicrobial treatment"

Open PhD position
Institute of Medical Microbiology, Lübeck, Germany.

I will be leading a new research group at UKSH Lübeck and we have an open PhD position starting April 2026.

Please share!

jobs.uksh.de/job/L%C3%BCb...

2 months ago 1 3 0 0