Thanks Christian!

We also provide the resource as an online interface that we hope will be useful to the metabolism community for discovery of proteins that regulate metabolic processes: mpca-chouchani-lab.dfci.harvard.edu

Using this method we discovered a protein that controls abundance and catabolism of the amino acid cysteine. Led by Haopeng Xiao, Martha Ordonez, and Emma Fink, and great collaborators at @danafarber.bsky.social @harvardcellbio.bsky.social @hhmi.org

Covariation MS uncovers a protein that controls cysteine catabolism - Nature A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

First post here! Excited to share a new paper and online resource from our lab published today. We developed a mass spectrometry approach that leverages genetic diversity to systematically nominate functional relationships between metabolites and proteins.
www.nature.com/articles/s41...