Steered generation for protein optimization: On datasets with ~10^2 measurements, steering a discrete diffusion model outperforms RL on a protein language model for generating improved variants.
@jsunn-y.bsky.social @francesarnold.bsky.social @yisongyue.bsky.social
arxiv.org/abs/2505.15093
Thank you to all of my co-authors: especially my co-lead, Ravi Lal, and advisors @yisongyue.bsky.social and @francesarnold.bsky.social!
Happy to share that our work on Active Learning-Assisted Directed Evolution is now published in @naturecomms.bsky.social!
Paper: www.nature.com/articles/s41...
Check out the original thread here: x.com/jsunn_y/stat...
Come visit our CARE benchmarks poster today at 11-2pm! (West Ballroom #5205)
I’m at NeurIPS this week presenting two of my recent projects!
Enzyme function classification (CARE) benchmarks: Friday 11-2pm West Ballroom #5205 @caltech.edu
Conditional generation from protein language models (ProCALM): Sunday at MLSB Workshop @Profluent
Please come say hi!