Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

I hope you find it useful! It was a pleasure exploring the data and ideas that our colleagues have contributed to this field over the past few years. We thought it was the right time to compile some mechanisms that could mediate nucleoid movement and share our perspective with the community 😊

How are mitochondrial nucleoids trafficked? Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (...

I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social
Available in @cp-trendscellbio.bsky.social

www.cell.com/trends/cell-...

#mito #mitochondria

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution - Cell Death & Disease Cell Death & Disease - OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution

Forgot to tag the protagonists of the story #mitochondria #mtDNA #nucleoids (I am new to this platform 😅).

Also, we started on this topic by looking at nucleoids in disease conditions! So if you are interested, you can check it out at www.nature.com/articles/s41...

Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....

🤗 Thank you, Dr. Isi!

I still haven't gotten over the shock of seeing the beautiful pearled landscape of the Mic10 KD cells! Thrilled and proud to have contributed to this story, and thank you @jclandoni.bsky.social and @sulianamanley.bsky.social for all your encouragement and @lycasworks.bsky.social for the STED fun 🔬🇨🇭

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

Stoked to share TWO preprints on mitochondrial pearling! 🎉
We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and
@gavsturm.bsky.social
et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪