Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Today in
@science.org:
We are pleased to present our last work entitled:
"Concurrent L1 retrotransposition events promote reciprocal translocations in human tumorigenesis"
by Zumalave et al.
www.science.org/doi/10.1126/...

Epigenetic memory of colitis promotes tumour growth - Nature Colonic stem cells retain a memory of inflammation following disease resolution and there is a mechanistic link between chronic inflammation and malignancy, suggesting potential strategies to mitigate...

A little late to Bluesky but my postdoc work w/ @jbuenrostro.bsky.social now out in @nature.com
"Epigenetic memory of colitis promotes tumour growth"
www.nature.com/articles/s41...

We wanted to understand how transient inflammation can create an increase in cancer risk, even after full recovery 🧵

🚨 New paper from our lab just published in Nature🚨

www.nature.com/articles/s41...

Discover how 🌱 tumour formation is shaped by tissue context from the very beginning. Cancer is not driven by genetics alone

✨Fantastic team led by Greta Skrupskelyte, Eduardo Rojo, @hariajith.bsky.social

Félicitations ! Et tout mes vœux de réussite dans cette nouvelle étape !

El proyecto empieza en septiembre, recibe el dinero finales de noviembre, ya la universidad está en cierre económico y puedes pedir materiales/fungibles a partir de mitad enero. Lógico.

¿Ha desaparecido la convocatoria de consolidación en 2026?
Además, se adelanta todavía más el proyecto de generación de conocimiento... A tomar en cuenta.

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...

Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

How Aspirin Prevents Metastasis

"Aspirin enhances antimetastatic immunity by decreasing platelet activation, thereby releasing T cells from suppression by thromboxane A2."

www.nejm.org/doi/full/10....

Free to read here: rdcu.be/d64zN

Finally published! Our work on how the #CircadianClock controls DNA repair. This has direct implications for cancer treatment: #Chronotherapy.
@CABIMER @UniSevilla

rdcu.be/eSwxl

Beautiful study and so clinically relevant! Congratulations to all the team.

Vaya, ¿ porque solamente este candidato está presentado en la cuenta oficial de la universidad de Sevilla?? ? O NO es una cuenta oficial?

eacr.org/conference/c...

😱🤩What a beautiful conference coming up (2026)! 😍
Chromosomes in crisis: From chromosomal Instability to Catastrophes in Cancer Genomes — join the EACR in Berlin, 3–5 Nov 2026!
Thanks to @helloeacr.bsky.social and the brilliant speakers for organizing this beauty!

La #AEI @ageinves.bsky.social del #MICIU publica la resolución de los proyectos #PID2024. Lo principal:
- El número de solicitudes de proyectos sube un 1️⃣0️⃣%. Genial, ¿no?? La ciencia crece en España, ¿no?? 😀

Pues no... 😕
- La financiación total se estanca.
- La financiación por proyecto baja.

Ongoing genome doubling shapes evolvability and immunity in ovarian cancer - Nature A single-cell sequencing study using more than 30,000 tumour genomes from human ovarian cancers shows that whole-genome doubling is an ongoing mutational process that drives tumour evolution and disrupts immunity.

Nature research paper: Ongoing genome doubling shapes evolvability and immunity in ovarian cancer

go.nature.com/40qLLcJ

Congratulations 🎉🎉👏🏻👏🏻👏🏻

Great discussion at the #EACR2025. Thanks to everyone who came to my poster yesterday for the feedback! @valcomaills.bsky.social @unisevilla.bsky.social

So much fun at Lisbon for the #eacr2025! Former and current investigators from @unisevilla.bsky.social 💃🏻👩🏻‍🔬 @helloeacr.bsky.social @livialopez.bsky.social and Sonia Silva from I3S.

Andy Moore @hhmijanelia.bsky.social created this video showing a cytoskeletal mechanism called an actin wave in a so-called HeLa cell. In orange are the actin filaments and in blue are the mitochondria, some of which appear to move with or be shifted by the active wave.

Inkscape plugin to rescale figures without distorting the text, and other useful features!
github.com/burghoff/Sci...

Huge shoutout to Javi (Fzco Javier Mendoza León), our Ph.D. student, for being awarded the AECC Predoctoral Fellowship 2025-Sevilla! 🎉 We hit the jackpot having you on the team!
Thank you so much @contracancerinv.bsky.social with @unisevilla.bsky.social
¡Enhorabuena a Javi! 👏

My gosh, what an incredible amount of work! So great to see those results coming through - both in your model and the TCGA data. Huge congrats!

Evolutionary fingerprints of epithelial-to-mesenchymal transition - Nature Malignant cells with mesenchymal features display increased chromatin accessibility, particularly in the pericentromeric and centromeric regions, in turn resulting in delayed mitosis and catastrophic ...

new out in @nature.com www.nature.com/articles/s41...

The 7 new #CancerGrandChallenges have just been announced! Read about them now in Cancer Discovery: doi.org/10.1158/2159...
@cancergrand.bsky.social

Ayer estuve en el II Encuentro de Investigadores AECC! 🔬💙
Gracias ♥️ @ContraCancerEs, @contracancerINV y voluntarios por hacerlo posible. Un día increíble para conectar, compartir ideas y recordar que nuestra investigación tiene un impacto real en los pacientes. 🚀 #encuentroinvestigadoresaecc!

So beautiful to see...

Bespoke vaccines can elicit long-lived immune activity against pancreatic cancer T cells induced by personalized pancreatic-cancer vaccines last for years.

This study found that RNA vaccines can induce an immune response in patients with pancreatic cancer

https://go.nature.com/4hI3XVL

Hello, Bluesky! ☀️

We fund frontier research in Europe—bold ideas, unexpected discoveries and science that shapes the future. So it’s only fitting we’ve landed here. Sorry for being late.

Follow us for updates on ERC funding, research policy, and our grantees' discoveries.

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...