Spindles lacking Ase1 adapt more resiliently to compressive force from the nuclear envelope than normal spindles.

Taylor proudly holds a troll doll named Thelonius she has adopted as a lab mascot, along with a copy of her preprint!

Final model figure of our manuscript indicates that compression force from the nuclear envelope regulates spindle biochemistry.

We've got a new preprint posted, you can read all about it (and see a picture of our recently adopted lab mascot) here: eltinglab.github.io/news/taylorB...

The bottom line of this work is that we reveal new ways that S. pombe spindle biochemistry is regulated by force from the nuclear envelope.

Yeah, that's what I'd done but still waiting. Hopefully I hear back soon!

Needhi do you know of any 'official' published policy with details about this accommodation? I've written my PO some time ago but haven't heard back (holiday backlog I suspect) so am still trying to figure out if I'm submitting for the next deadline, which feels like it's rapidly approaching!

Wonderfully clear thread about some of the things ‘indirect costs’ support

Of all the takes on this story, this is clearly the right one

I mostly agree with the original take (fancy potatoes forever!) but this is the one thing pulling me back.

Excited to share our new study with the Müller and @SchullerJm labs, online @nature: https://www.nature.com/articles/s41586-022-04971-z

This is T. kivui, an anaerobic bacterium. It uses hydrogen energy to store #CO2. How does it do it? #CryoET revealed membrane-anchored bundles of...

But please, let’s try again next week!

Yesterday I thought it was almost the weekend … so honestly pretty relieved you got this one wrong. If it were only Tuesday, not sure I’d make it through this week.

Brings to mind this quote from Stephen J Gould: "I am, somehow, less interested in the weight and convolutions of Einstein's brain than in the near certainty that people of equal talent have lived and died in cotton fields and sweatshops."

📌

A collage of different cells stained green for actin polymer and pink for DNA (a single circle in most of the cell types). A large mouse skin cell on the top right hovers over the smaller amoebae and yeast cells below. A column of corn epithelial cells runs along the left, with one cell in the center dividing. A small listeria bacterium (pink) rockets in from the top using an actin comet tail. A branchy amoeba sits at the lower right corner. About 7 other cell types are smattered around.

Happy #microscopymonday!
Here is a collaborative project I started in ~2018, looking at different cells stained for actin and DNA and all set to the same scale. More info (and poster printouts!) here: katrinavelle.wixsite.com/science/prin...

Do you sell these posters anywhere? I would love to have a nice art print of one and for you to get a cut. :)

Q: What's wrong with these plots?

A: Pooling cell-level measurements across multiple runs conceals experimental reproducibility.

Read more in JCB (with @fritzlaylin.bsky.social @katrinavelle.bsky.social & Dyche Mullins): rupress.org/jcb/article/...

Every time I see this movie it looks like embroidery to me. And now that might be a thing I have to figure out how to make. But maybe someone has already done this? Other scientists who stitch on here?

Child with a book open to the periodic table copies the chart onto a piece of a paper

I swear I didn’t put J up to this. But y’all. What if I’m raising a chemist?! 🙈
#physicistMom

Hi Arthur! Good to see you here!

Is this cat as gigantic as it appears?

Probably my favorite movie I’ve seen this year, thanks Needhi for verbalizing what I found so moving about it

My eldest now voluntarily washes dishes and it is the absolute BEST.

Oh this is an interesting interpretation! I think I'm also a little bit irrationally worried that it's the *sample* that might be looking back at me (what about those zebrafish we're torturing?), but it could be the scope itself! Either way I think this could be a fun one to animate.

I’ve got one for a dad, which means I have had this Grant for nearly 40 years now

Glad we cleared that up 😂

Wallace. I have questions. (Mostly about the chair level pan of EtBr?!!?!)

I did my first protein prep (myosin VI!) using tap water. Yeah, I was ‘that physicist.’

Not a literal fear, but when I was starting out as a microscopist, I had a weird feeling of unease every time I approached the eyepieces that something was going to be looking back at me. Could make for a good animation?

This happened to me (flooding from the floor above) during my postdoc. Luckily (?) it was mostly on the computer and stage controller (both of which had to be replaced). Someone upstairs had let a sink run until it overflowed! 😡

This keeps coming across my feed and every time I get it in my head again. Why’d you choose violence, Michael?

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN

Hi, thanks for making this! I'd also love to join if there's still room. :) Thanks!