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Haben Sie dieses kleine Review gesehen @ralfwittenbrink.bsky.social ?

https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1471192/full

https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2024.1471192/full

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www.frontiersin.org/journals/cel...

The impact of COVID-19 on accelerating of immunosenescence and brain aging

Ludmila Müller
Svetlana Di Benedetto

Max Planck Berlin 🧪

Dezember 2024

⚠️ immunosenescence ⚠️

To wear N95 in healthcare by practicers and visitors and to manage #CleanAir by airfilters and CO2 monitoring will reduce considerably HAI, especially sepsis due to airborne transmission and limit nosocomial infections.
😷
It's time guys to act proactive for airborne transmission prevention guidance✅️

Berliner Forschungsgruppe: Corona schleicht sich über Immunzellen in L Ein Forschungsteam unter Leitung der Charité hat herausgefunden, dass Lungenschäden bei Covid-19 auf eine durch Makrophagen ausgelöste Immunaktivierung zurückzuführen sind.

Hocke: „Unsere Studie deutet darauf hin, dass schwere Lungenschäden bei Covid-19 eher auf eine durch Makrophagen ausgelöste Immunaktivierung als auf eine direkte Zerstörung der Lungenbläschen durch das Virus zurückzuführen sind."

www.universimed.com/de/berliner-...

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilises the angiotensin-converting enzyme 2 (ACE2) transmembrane peptidase as cellular entry receptor. However, whether SARS-CoV-2 in the alveolar compartment is strictly ACE2-dependent and to what extent virus-induced tissue damage and/or direct immune activation determines early pathogenesis is still elusive.MethodsSpectral microscopy, single-cell/-nucleus RNA sequencing or ACE2 “gain-of-function” experiments were applied to infected human lung explants and adult stem cell derived human lung organoids to correlate ACE2 and related host factors with SARS-CoV-2 tropism, propagation, virulence and immune activation compared to SARS-CoV, influenza and Middle East respiratory syndrome coronavirus (MERS-CoV). Coronavirus disease 2019 (COVID-19) autopsy material was used to validate ex vivo results.ResultsWe provide evidence that alveolar ACE2 expression must be considered scarce, thereby limiting SARS-CoV-2 propagation and virus-induced tissue damage in the human alveolus. Instead, ex vivo infected human lungs and COVID-19 autopsy samples showed that alveolar macrophages were frequently positive for SARS-CoV-2. Single-cell/-nucleus transcriptomics further revealed nonproductive virus uptake and a related inflammatory and anti-viral activation, especially in “inflammatory alveolar macrophages”, comparable to those induced by SARS-CoV and MERS-CoV, but different from NL63 or influenza virus infection.ConclusionsCollectively, our findings indicate that severe lung injury in COVID-19 probably results from a macrophage-triggered immune activation rather than direct viral damage of the alveolar compartment.

2️⃣0️⃣2️⃣2️⃣🧪

Human lungs show limited permissiveness for SARS-CoV-2 due to scarce ACE2 levels but virus-induced expansion of inflammatory macrophages

Katja Hönzke Benedikt Obermayer Christin Mache et al.

European Respiratory Journal 2022 60(6): 2102725;

DOI: doi.org/10.1183/1399...

ALA Clean Air School Symposium NOTE: All times listed below are in Central Time. Agenda times and order of topics are subject to slight change. 10:00 AM: Opening Remarks + The Case for Indoor Air Quality (IAQ) 10:50 AM: Core Elements and the Intersection of IAQ and Energy Efficiency 11:25 AM: Voices from the Field - a Panel Discussion 11:55 AM: Break 12:05 PM: Taking Action: 6 Key Drivers 12:35 PM: How to Make it Happen - Programs and Resources for Schools 12:50 PM: Voices from the Field - a Panel Discussion 1:30 PM: Closing Remarks and Adjourn Featured Speakers Speaker list and bios coming soon!

The American Lung Association is hosting a 3.5-hour virtual "Clean Air School Symposium" on May 5.

Register: action.lung.org/site/TR?fr_i...

Il a de nombreuses excentricités et a commis des erreurs, mais il était l'un des rares à comprendre l'importance de la surveillance des eaux usées et des tests au chevet des patient même asymptomatiques. Il a également évoqué très tôt l'impacte des éleveurs de visons et l' évolution de variantes.

All of that said, essentially the first obstacle we must deal with is the idea of pandemic denialism. We are like lemmings at this point. There is no real appreciation at the public level for the scale of threat we are facing.

Five years of the COVID-19 pandemic: An interview with Dr. Arijit Chakravarty In this interview, Dr. Chakravarty discusses the current state of the COVID-19 pandemic and public health globally five years after the initial outbreak of the SARS-CoV-2 virus in Wuhan, China.

Public Health was saying, “Masks are the scarlet letter of the pandemic,” in the words of former CDC Director Rochelle Walensky. Or “If you have been vaccinated, the pandemic is over for you,” www.wsws.org/en/articles/...

bsky.app/profile/casa...

T cell apoptosis characterizes severe Covid-19 disease - Cell Death & Differentiation Cell Death & Differentiation - T cell apoptosis characterizes severe Covid-19 disease

Friendly reminder

SARSCoV2 infections are characterized by lymphopenia, but the mechanisms involved are still elusive.

There was this publication
22 January 2022

👇
T cell apoptosis characterizes severe Covid-19 disease

www.nature.com/articles/s41...

Simultaneous detection of multiple viral pathogens in vacuumed dust from different building types Environmental monitoring of viral pathogens will be a critical tool to prevent morbidity and mortality in future pandemics and yearly disease cycles. …

Settled dust shows lots of viruses are in our schools and offices. 85% of samples had at least one rhinovirus.
www.sciencedirect.com/science/arti...

Fungal emissions from air conditioning cooling coils The fin-and-tube heat exchangers from air conditioning (AC) units are known locations of microbial growth within the built environment. Prior studies …

HVAC coils have some fun(gal) secrets...

www.sciencedirect.com/science/arti...

Interior of a train featuring patterned seats in purple, blue, and red. A reflection of a person wearing a mask is visible in the window.

Still masking on public transportation. Given the number of people who are coughing and sneezing, I’m pretty happy with the choice.

🔝@amandalhu.bsky.social 📌

💖

FFP vrs MNS

Masken sind unterschiedlich!

es geht um solche, die tatsächlich vor infektiösen Aerosolen schützen,
wie z.B. die Aura 3M Fischform

Der Platz auf der 👃 wird vom Bügel bedeckt und die Auflage wird durch die 😷 für die 👓 verändert

Quelle Amanda Hu.

✅️

FFP vrs MNS

Masken sind unterschiedlich!

es geht um solche, die tatsächlich vor infektiösen Aerosolen schützen,
wie z.B. die Aura 3M Fischform

Der Platz auf der 👃 wird vom Bügel bedeckt und die Auflage wird durch die 😷 für die 👓 verändert

Quelle Amanda Hu.

✅️

Da die Brille mit FFP Maske getragen wird, wird auch mit FFP Maske die Brille anprobiert.

Sonst sitzt sie nicht richtig.

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Who profits from the "Normalization of Sickness"?

A powerful alliance of Big Tech, Pharma, and specialized IT firms is turning human frailty and digital transparency into a trillion-dollar asset.

#BioPolitics #DigitalControl

Erlernte Hilflosigkeit: Wenn jede Eigeninitiative für echten Schutz (z. B. Masken, Luftfilter) stigmatisiert wird, geben Menschen irgendwann auf.

Sie fügen sich in das Schicksal der „Dauerdurchseuchung“, um dazuzugehören.

Warum ist der Widerstand so gering? Weil Resignation und tief sitzende Ängste die Urteilskraft zersetzen. Eine erschöpfte Gesellschaft ist leichter zu steuern und stellt keine unangenehmen Fragen mehr.

Die totale Abhängigkeit: Die Kombination aus emotionaler Aufladung und technokratischer Umsetzung führt in eine Gesellschaft, die aus Angst vor Gewalt ihre Freiheit opfert.

Wir brauchen Schutzkonzepte, die auf Rechten basieren, nicht auf totaler digitaler Transparenz

The Consequence:

Total Dependency. We are trading actual physical protection (like clean air or crime prevention) for a digital panopticon.

A society that sacrifices privacy for a false sense of security ends up with neither.

We must resist the "moral" mandate for total transparency

Palantir in the background: While CGM and Google collect the data, Palantir provides the analytical power for security agencies.

Circumventing data protection regulations, profiles are created that make every movement of the population predictable and controllable.

The compulsion to use a smart eID:

If a digital ID becomes a prerequisite for banking, doctor's appointments, and dealing with government agencies, there is no escape

Those who don't participate will be "digitally dealt with"
isolated from social and economic life.

A state of digital coercion.

The "Moral Trap":

How outrage over online violence is strategically weaponized to mandate Digital IDs and mass surveillance.

A sophisticated blueprint to dismantle anonymity under the guise of protection.

The Illusion of Safety: Projects like "Chat Control" or mandatory age verification don't stop predators;

they create a backdoor to every citizen's private life. The emotional appeal of
"child/women- safety" is used to silence legitimate concerns about civil liberties

AI failure to admit
"I don't know"
and instead doubling down on flawed textbook theories is exactly the kind of "AI hallucination" that undermines trust and spreads misinformation.
Here is a thread summarizing this failure and the danger it represents:

"I Don't Know"

is a Valid Answer 🚫

The hardest thing for a Large Language AI Model to do is admit a void.

But in science, "we don't fully understand the long-term salt-balance of the lithosphere" is a much more honest and useful answer than a made-up "geological drain."

Narrative over Physics

AI models are trained on vast amounts of text. If 90% of textbooks repeat a simplified "cycle," the AI will prioritize that narrative over the first principles of physics.

It chooses "sounding right" over "being right."