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Posts by Owen Dando

🚨 New preprint

11,000+ human brain microvessels in cSVD.

Key findings:
β€’ Early, bimodal pericyte loss
β€’ Endothelial activation comes later
β€’ Venous-like microvascular shift
β€’ Capillary density ↑

πŸ’‘ Suggests a sequential vascular pathology, not parallel.

πŸ”— www.biorxiv.org/content/10.6...

4 weeks ago 6 3 0 0

We are looking for a bioinformatics postdoc to join our group! Apply here πŸ‘‡πŸ‘‡πŸ‘‡

www.jobs.ac.uk/job/DPQ109/p...

4 months ago 2 3 0 0
Fig. 1: Establishment of methods to identify astrocyte endfoot proteins. | Nature Communications

Finally it’s here! πŸŒŸβ¬‡οΈ

www.nature.com/articles/s41...

I’m sooo excited to share our latest article led by Steve Hill and Isabel Bravo-Ferrer
1- How does the vasculature communicate with astrocytes?
2- Is this communication dependent to what happens in the body.
3- Is it relevant to human diseases?

5 months ago 27 10 5 1
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SIDB and @ukdri.ac.uk researchers at The University of Edinburgh and @ncbsbangalore.bsky.social have found that FMRP maintains the form and function of neuron-maintenance cells, essential for rapid and efficient neuron communication.

Read more: www.sidb.org.uk/news-events/...

1 year ago 7 2 1 0
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The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology inΒ vitro. FMRP-deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in m...

onlinelibrary.wiley.com/doi/full/10....
Hot off the press! We find changes in oligodendrocytes that lack FMRP! An excellent collaboration supported by @sidb-edinburgh.bsky.social .

1 year ago 12 4 1 1
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We are still recruiting for PhD studentships in basic & translational brain sciences! SIDB provides an annual stipend of Β£25K, plus tuition fees (inc. international).

Find out more & apply by 26th Jan >> sidb.org.uk/phds/

#ExtraordinaryEdinburgh @edinunineuro.bsky.social

1 year ago 8 10 0 0
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Precision Medicine DTP - Defining vascular-immune cell heterogeneity and and intercellular communication in human vascular disease and dementia at University of Edinburgh on FindAPhD.com PhD Project - Precision Medicine DTP - Defining vascular-immune cell heterogeneity and and intercellular communication in human vascular disease and dementia at University of Edinburgh, listed on Find...

PhD opportunity – come and work with us on a PhD investigating immune-vascular interactions in human vascular dementia using snRNAseq analysis and spatial transcriptomics with Professor Karen Horsburgh, Dr Jill Fowler and Prof Raj Kalaria.
www.findaphd.com/phds/project...

1 year ago 0 2 0 0