Carriers of the LOF KATP variant exhibited a shift from hypoglycemia to diabetes, as has been reported previously in some carriers of KATP LOF variants.
Read here ➡️ doi.org/10.2337/db25-1098
The cover of the May issue of Diabetes.
⭐ 📖 Paper of the Month: May
Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis ➡️ https://doi.org/10.2337/db25-0644
Articles chosen 🗓️ monthly & 🆓 online #paperofthemonth #diabetes
"The Takeoff," oil and graphite on canvas, 2025, Sarita Fonseca, MBA, CFAE. This artwork is an adaptation of a photograph taken at the New Orleans Congo Square Rhythms Festival by Eric Simon, MD, Tulane University School of Medicine, New Orleans, LA
👀 The May 2026 Diabetes Care is here, with the latest research on #diabetes management.
🔗 http://diabetesjournals.org/care/issue/49/5
Featuring:
✨GLP-1s & Diabetic Foot Ulcers
✨Glycemic Biomarkers & Patients Treated w Maintenance Dialysis
✨& more!
Neonatal islet showing proliferating β-cells. Shown is the mouse pancreatic section, highlighting proliferating cells (red) and insulin-positive β-cells in green. Nuclei are blue. Photography is courtesy of Katherine C. Perez and Sushant Bhatnagar, Comprehensive Diabetes Center and Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of Alabama, Birmingham, AL. Their article, “Tomosyn-2 Regulates Postnatal β-Cell Expansion and Insulin Secretion to Maintain Glucose Homeostasis,” appears in this issue of Diabetes
🚨The May 2026 issue of Diabetes has arrived!
🔗 http://diabetesjournals.org/diabetes/issue/75/5
Explore the latest research on #diabetes, including:
✨Quantitative β-cell mass imaging
✨Tomosyn-2 & Insulin Secretion
✨& more!
A graphic titled "Increasing Insulin Pump Use in Publicly Insured Children and Adolescents with Type 1 Diabetes." It features three sections: Disparity, Interventions, and Outcomes. Under Disparity, an icon with a speech bubble indicates that publicly insured youth use insulin pumps less. Interventions include "Provider Awareness & Education," "Patient Education & Knowledge," and "Patient-Centered Care," each with relevant icons. The Outcomes section shows two figures: baseline 30%, and increases to 46% at 12 months and 73% at 44 months, depicting growth in insulin pump use. A note beneath reads, "Equity-centered quality improvement sustainably increases insulin pump use."
An equity-centered, EHR-informed QI approach led to durable improvements in insulin pump use among publicly insured youth with T1D.
Read here ➡️ doi.org/10.2337/doc26-0006
CGM with remote patient monitoring for pediatric patients newly diagnosed with type 1 diabetes is cost-effective compared to self-monitoring of blood glucose and to CGM alone. #DCare #Article
Read here ➡️ doi.org/10.2337/dc25-2825
Graphic illustration featuring various colorful speech bubbles containing symbols like a sound wave, quotation marks, a question mark, a smiling emoji, and a thumbs up, set against a teal background.
Stay connected!
🦋 Bluesky: ADA Publications | bsky.app/profile/adapubs.bsky.social
📢 X: @ADA_Pubs | @DiabetesCareADA | @Diabetes_ADA
📘 Facebook: ADA Publications | facebook.com/adaPublications
🎙 YouTube: American Diabetes Association | youtube.com/@AmericanDiabetesAssn/podcasts
The image is a summary chart of the TULIP Study, focused on long-term weight loss over 3%. It includes diagrams, graphs, and pie charts. A pie chart shows participant distribution: 62% had weight loss ≥3%, while 38% had <3%. Two graphs depict fasting glucose and insulin secretion across clusters 1, 2, 4, and 5. The fasting glucose graph shows an increase for cluster 5, while the insulin secretion graph shows a decrease for the same cluster. Another pie chart describes the distribution of a specific group among different clusters. A box labeled "Conclusion" states: "Despite a sustained and large amount of weight loss, people in diabetes risk cluster 5 had deterioration of glycemia, the largest decrease of insulin secretion among the clusters and a high risk of T2D."
Diabetes risk cluster 5 participants had an impaired response regarding improvement of glycemia and insulin secretion and a high risk of developing type 2 diabetes, despite a long-term (9-year) mean weight loss of 8%.
Read here ➡️ doi.org/10.2337/db25-0757
Informative infographic showing hypercholesterolemia and lipid-lowering medication (LLM) in children with type 1 diabetes. It includes three sections: prevalence, treatment frequency, and target achievement. Prevalence shows 60.9% had high LDL cholesterol, with varied distribution of LDL levels. Treatment frequency indicates 3.5% received LLM. Target achievement shows 15.7% reached LDL cholesterol target with LLM, compared to 6.2% without treatment. Text notes that despite guidelines, only 7.3% received LLM, and over 90% of those untreated didn’t achieve cholesterol targets.
The prevalence of LDL-hypercholesterolemia in children with type 1 diabetes was high, but the treatment frequency remained low and treatment targets were not achieved. #DCare
Read here ➡️ doi.org/10.2337/dc25-2459
A graphic with a dark blue background featuring the text “Thank you to our reviewers,” “Thank you for your valuable feedback,” and “Thank you for your expertise” in white uppercase letters. Two outlines of clapping hands are in the background.
🥳 The American Diabetes Association would like to extend our sincere gratitude and appreciation and give a huge shout-out to our top expert reviewers. ADA's Diabetes journal would not be possible without you! Thank you for advancing the research and accelerating the cause.
https://bit.ly/4mjl6bm
Red background with three bold white text phrases: "Thank you to our reviewers," "Thank you for your valuable feedback," and "Thank you for your expertise." Faint line art of clapping hands in the background.
🥳 The American Diabetes Association would like to extend our sincere gratitude and appreciation and a give a huge shout-out to our top expert reviewers. Diabetes Care would not be possible without you! Thank you for advancing the research and accelerating the cause.
https://bit.ly/4dG6pwP
Flowchart depicting a study on weight loss paths over 24 months. It starts with randomization into two groups: Control and Caloric Restriction. Both lead to Initial Temporary Weight Loss at 12 months. Outcomes at 24 months include Weight Gain (>5%), Stable Weight, and Sustained Weight Loss, each with corresponding symbols indicating metabolic benefits: a minus (red), a plus (blue), and a double plus (green).
In CALERIE-2, weight regain after caloric restriction reversed gains in insulin sensitivity & IGF-1 bioavailability. Sustained weight reduced biological age and diabetes risk. #Aging #CR #DCare
Read here ➡️ doi.org/10.2337/dc25-1911
🚨 NEW special Diabetes Core Update #podcast
In this special episode of Diabetes Core Update, Neil Skolnik explores new emerging technologies for people with diabetes.
👂 Listen now at: diabetesjournals.org/journals/pag...
Global Reach🌍 . Practical Insight. Our journal portfolio delivers highly cited, mission-driven research that advances diabetes and obesity science and care worldwide. Now expanded with Diabetes, Obesity, and Cardiometabolic CARE® Explore: https://bit.ly/4lbA0QB
#Portfolio #DOCM #Diabetes #DCare
The image is a flowchart depicting five cycles of a process with an upward arrow. Each cycle contains a circle with letters "A," "P," "S," "D" arranged in quadrants. Cycle 1: Separated physician and education visit templates for CGM education. Cycle 2: Added group classes to accommodate more patients. Cycle 3: Created standardized curriculum with case studies. Cycle 4: Revised curriculum and case studies with feedback for multi-level class creation. Cycle 5: Revised presentation of content for health literacy needs.
Multi-level QI efforts in an urban safety-net hospital tackling system barriers, reducing provider bias, and strengthening team-based patient support—moved the needle on real-world CGM access. #T1D #DOCM
Read here ➡️ doi.org/10.2337/doc25-0043
The image is an infographic summarizing a clinical trial on semaglutide effects on insulin sensitivity and β-cell function in patients with schizophrenia, prediabetes, and obesity. It shows a randomized, placebo-controlled trial conducted over 30 weeks. The "Population" section is represented by an illustration of diverse individuals. The "Intervention" section states semaglutide weekly or placebo. Main results include reduced fasting glucose (0.87 mmol/L), improved insulin resistance (0.9), and a weight loss of 9.2 kg. The conclusion highlights improved insulin resistance, lower fasting glucose, and a weight-loss promotion.
Semaglutide significantly improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and promoted substantial weight loss in patients with antipsychotic-induced metabolic disturbances.
Read here ➡️ doi.org/10.2337/dc25-2041
This image is a flowchart comparing the effectiveness of Tirzepatide versus Dulaglutide and Semaglutide on major cardiovascular events in type 2 diabetes and cardiovascular disease. The chart includes two parallel paths for each drug, both starting from adults initiating treatment, and moving through various analyses of major adverse cardiovascular events (MACE). Key results are highlighted with cumulative incidence percentages and hazard ratios. A note at the bottom explains the study's conclusion, emphasizing Tirzepatide's lower risk of MACE compared to the other drugs.
Among adults with T2D and ASCVD in routine care, tirzepatide was associated with a lower risk of modified MACE when compared with dulaglutide, driven by reduction in all-cause mortality.
Read here ➡️ doi.org/10.2337/dc25-3063
A professional headshot of an individual is accompanied by text and graphs. The text highlights Richard R. Rubin, PhD, a psychologist and professor from Johns Hopkins University, noting their contributions to diabetes research. Key foundations championed by Rubin include psychological, biological, and social aspects of diabetes. A graph illustrates the growth of diabetes-related research publications from 1980 to 2024. Additional text lists impactful areas of Rubin's work, such as addressing behavioral changes, social influence, and patient-centered care.
Psychological complexity in diabetes spans families, communities, peer/social support, flexibility in programs and the research that guides them, and living well even with an often horrible disease. #DOCM
Read here ➡️ doi.org/10.2337/doci25-0001
This image is an infographic titled "Social Adversity Profiles are Differentially Related to Diabetes Status Over Time." It outlines the study's objective, design, and results related to Hispanic/Latino adults. Key elements include an objective to identify patterns of social adversity affecting diabetes status, and a design involving two visits and three levels of diabetes status: normoglycemia, prediabetes, and diabetes. The results section features a line chart comparing four social adversity profiles over various factors. The "SOL" logo and "Hispanic Community Health Study" are at the bottom.
Four profiles of social adversity (low adversity, social-educational strengths, acculturated and under-resourced, and high adversity) differentially predict worsening diabetes status across 12 years. #DCare #Article
Read here ➡️ doi.org/10.2337/dc25-2797
A diagram illustrates research on 5,229 participants from 16 U.S. cohorts. It shows a pregnant person over a U.S. map, with test tubes indicating serum or plasma taken during pregnancy. Several chemicals are listed: PFOA, PFOS, PFHxS, PFNA, PFDA, MeFOSAA. An arrow points to "Gestational diabetes" and "Fasting glucose" with a question mark. The Environmental influences on Child Health Outcomes (ECHO) logo appears on the right.
In a large, pooled sample of US pregnant women from the NIH ECHO Cohort Consortium, greater concentrations of PFAS were not associated with higher prevalence of GDM. #DCare #Article
Read here ➡️ doi.org/10.2337/dc25-1340
Diagram illustrating a biochemical pathway. Glucose is converted to glucose 6-phosphate, uses ATP, and produces ADP. G6PD enzyme converts glucose 6-phosphate to 6-phosphogluconate, producing NADPH from NADP+. This continues with 6PGD enzyme, maintaining NADPH levels. The pathway leads to erythritol and fat production, with pyruvate converting to acetyl-CoA, marked as DNL.
Metabolite erythritol in 24-h urine is associated with higher intrahepatic lipid content. #Diabetes
Read here ➡️ doi.org/10.2337/db25-0881
The image shows three line graphs comparing hazard ratios of Type 2 Diabetes risk to standardized mtDNA copy number across different age groups from two studies: KARE and UKB. Each panel represents a different age group: 40-55 years, 56-65 years, and 65+ years. The top graphs highlight U-shaped curves for each study, with KARE in blue and UKB in red. The bottom graph shows a shaded area with a downward trend in mtDNA-CN over age. A text box emphasizes the coincidence of the U-shaped relationship with the decline in mtDNA-CN.
Study finds a U-shaped link between blood mtDNA copy number and type 2 diabetes risk. Both low and high levels raise risk in the young, challenging prior linear views. #DCare
Read here ➡️ doi.org/10.2337/dc25-2198
@American Diabetes Association
The image is an infographic titled "Machine Learning Models to Predict Type 2 Diabetes Development Among Youth With Prediabetes." It shows a flowchart of a study by a large Midwest health system with 532 participants. The flowchart includes: predictor set 1, containing variables like age, race, BMI, and HbA1c; predictor set 2, including area deprivation index (ADI); and classification using logistic regression. A comparison shows a higher AUC (0.73) with ADI. Additional notes mention utilizing electronic medical records and predictive features.
A new study shows adding a socioeconomic maker to HbA1c improves a prediction of which youth with prediabetes are more likely to develop type 2 diabetes in the next year. #Dcare
Read here ➡️ doi.org/10.2337/dc25-3060
Silhouettes of diverse profiles in various colors are displayed on a white background. The accompanying text reads: "2026 Abridged Standards of Care. Abridged for Primary Care Professionals" on a red textured background.
Just released!🚨 The 2026 Abridged Standards of Care for Primary Care professionals contains the evidence-based clinical practice recommendations most pertinent to primary care. Now hosted in ADA's new journal, Diabetes, Obesity, and CardioMetabolic CARE. #DOCM
Read free ➡️ https://bit.ly/48gGFU5
This image is a timeline chart illustrating a study on mice related to obesity and stroke recovery. It includes labeled phases: "Induction of Obesity/T2D," "Treatment," "Off treatment," and "Poststroke recovery," spanning various weeks. Mice are shown in different conditions, with treatments like "PBS," "NPH-Ins," "LaGCGRA," and "Lean" indicated. Key elements include HFD (High-Fat Diet), OB (Obesity), HG (High Glucose), and NG (Normal Glucose). There are markers for metabolic tests, stroke induction, grip strength tests, and inflammation testing. An inset shows a histological sample.
Targeting insulin resistance, rather than hyperglycemia, before stroke in #T2D is crucial to improving stroke outcomes. #Diabetes
Read here ➡️ doi.org/10.2337/db25-0532
The Points of CARE podcast logo, featuring the image of a red microphone against a blue, honeycomb background, and the insignia of the American Diabetes Association
🚨 A new journal for a new #podcast.
The Points of CARE w Richard Beaser, MD & Jane Reusch, MD will cover highlights in each issue of Diabetes, Obesity, and Cardiometabolic CARE.
In episode 2:
✨ CGMs & T2D
✨ START Diabetes Prevention
✨ & more!
🎧 bit.ly/DOC_Update
📚 diabetesjournals.org/docm-care
An illustration of a woman walking amongst four circles, each circle depicting an aspect of diabetes care.
👀 The 2nd issue of Diabetes, Obesity, and CardioMetabolic CARE (DOCM CARE), the new ADA journal focused on comprehensive, person-centered care, is live.
🔗 diabetesjournals.org/docm-care
Featuring:
✨ Diabetes Nutrition Therapy
✨ START Diabetes Prevention
✨ & more!
This flowchart depicts a study on screening for Cystic Fibrosis-Related Diabetes (CFRD) using a 50-gram Oral Glucose Challenge Test (GCT). It starts with 185 participants, of which 51% had normal glucose tolerance (NGT), and 49% had elevated GCT results (≥147 mg/dL). Of those elevated, 12 underwent an Oral Glucose Tolerance Test (OGTT), revealing 9 had CFRD. The chart includes icons representing sets of ten participants and uses arrows to illustrate the screening process. A legend clarifies the symbols used for NGT.
A random 1-hour, 50g oral glucose challenge test is an effective screening tool for cystic fibrosis-related diabetes and can reduce the need for annual OGTT by 50% in people with cystic fibrosis. #DCare #Article
Read here ➡️ doi.org/10.2337/dc25-2806
The DiabetesBio logo, featuring a red microscope graphic and the insignia of the American Diabetes Association
🚨 New for April, a fresh episode of the #DiabetesBio #podcast!
Featuring:
✨ Sex Differences in Diabetes Progression
✨ Children & Islet Autoimmunity
✨ + Sweet Talk w Lora Heisler
🎙️Listen: http://diabetesbio.libsyn.com
📚Read: http://diabetesjournals.org/diabetes/issue/75/4
🧠 Share your comments!
📚 NEW: 2025-26 Guide to Diabetes Medications—complete reference for clinicians. All drug classes + comorbidity management.
📖 Chapters: doi.org/10.2337/978158040846
🛒 Print: shopdiabetes.org/collections/professional-books/products/2025-26-guide-to-medications-for-the-treatment-of-diabetes-mellitus
