Proud to share our latest paper in @rscchembio.rsc.org, where we tackle oncogenic TRK fusions. Together, @sauravk05.bsky.social and Jiewei Jiang develop potent and selective degraders of the TPM3-TRKA fusion, a key cancer driver. pubs.rsc.org/en/content/a...
Good luck @fredhutch.org applicants!
"We cannot just say ‘okay, we're going to stop work on anything that is not related to human research’, because – actually – it's all relevant to humans."
We get plenty of snark and late night comedy, but not a mature forum informed by experts with the gravitas the moment requires.
We simply don't have the institutional skill, experience or will to even discuss as grownups the mental state of the president: not the cabinet, not the Congress, not the Supreme Court, not the "4th estate" serious media. Just mass paralysis and silence in the face of clear and present danger.
@behnamnabet.bsky.social at Fred Hutch Cancer Center is doing important work on KRAS degraders www.fredhutch.org/en/news/cent...
Pleased to share our recent work out today in @natmetabolism.nature.com. This study addresses a longstanding mystery - NRF2-driven cancers increase cysteine acquisition (via xCT) by ~5x - so where does all that cysteine go?
Writing makes thinking explicit. There are thoughts we don't know we're thinking until we discover them through writing. Writing teaches us our own minds: what we're thinking and where our thinking needs work. It's diagnostic. My writing teachers (one in poetry, one in journalism) taught me that.
Impeach is the word of the day and the week and the month. Impeachment now.
Just scanning his posts I immediately appreciate how non-ideological he is, even on old sandtraps like direct instruction v. Inquiry.
Looking forward to reading this. Though it takes a lot of work to build a classroom culture, one of the benefits of harnessing that stubborn sociality is creating opportunities for students to teach each other... sometimes a student can just break it down for a peer better than the teacher can.
Since I'm getting a questions about the new data - a few _preliminary_ comments:
1️⃣ Are the outbreaks in the US connected?
👉 Very likely.
2️⃣ Does this mean US will lose elimination status?
👉 Yes, but that's been clear for a while.
Data: nextstrain.org/measles/geno...
A few details + caveats 🧵👇
From Newport, Oregon on one end of US 20 to Boston, MA, sea to shining sea.
#NoKings in Newport, Oregon, one of many up and down the beautiful Oregon coast!
Remember this when you hear someone opine that there's not a dime's worth of difference between the parties, it's just two wings of the business party, etc. There's a cost in human life when D's lose elections. That should count in the moral calculus of withholding support from flawed candidates.
1. A #flu update:
#CDC has learned of 8 more pediatric flu deaths, bringing this season's total to 123. That number will continue to rise; deaths are often reported on a delay.
Case in point: 2024-25's peds death total rose by 1 last week with a death from Feb '25 just reported.
~85% were not vaxed.
Enjoyed many of his books, especially a quiet one called Old Friends about life in a nursing home.
Salute to Susan Parkhurst, the newest AAAS fellow from Fred Hutch Cancer Center @fredhutch.org @basicsci.fredhutch.org
This is more than a threat to a field of research, it's a threat to 21st century civilization: "We are living through a period in which the scaffolding underpinning entire bodies of knowledge is no longer secure."
I dunno, better SNAP benefits and wider access to SNAP-Ed classes on shopping, meal planning and cooking for starters, but mainly promoting a culture that regards these skills as essential for independent adult life, regardless of gender, beginning in but not limited to K-12 schooling.
There are ways to discuss the president's mental state responsibly, with experts, without making a clinical diagnosis. The fact that the most serious precincts of "the media" abdicate this responsibility and refuse to convene these experts and host this important debate is an institutional failure.
There's a lot of hidden labor in feeding a family -- time, sufficient money, housing stability, time and grace to make mistakes and learn new skills. We could do more as a society to make that labor a bit less onerous.
Not in any way an expert, and speaking only for myself, it took me decades of learning how to shop, maintain a pantry of essentials, acquire a serviceable array of pots, pans, knives etc, and most of all, learning how to cook to make a mostly vegetarian diet delicious and sustainable.
"The fingerprint evidence shows that bead-making was not limited to a small group of specialists. Instead, individuals of different ages, including children, took part in shaping these objects, indicating the process unfolded in shared, social settings."
Awesome comic!
"We're both part of the same hypocrisy, but never think it applies to the good citizens of Maine"
Seattle should appreciate what an increasingly rare thing it is to have a real independent local newspaper (with a Sunday Magazine!) doing real journalism and not some hedge fund-owned, skeleton crew-operated, AI-boosted, content-cranking outfit milking the last dime out of a newspaper in name only.
The North remembers!
It was a highlight of my Knight Science Journalism Fellowship year. Sad that it has to be this way, but glad the organizers recognize the moment and are responding appropriately.