Degradation of Abl Utilizing an Immunoproteasome N-Degron Prodrug Targeted protein degradation is an emerging therapeutic strategy that leverages the cell’s natural protein clearance pathways to eliminate proteins of interest (POIs). One common approach involves bif...

New degrader paper using the immunoproteasome. Congrats Cody Loy and Tim Harris!
pubs.acs.org/doi/full/10....

NMR-Guided Studies to Establish the Binding Interaction between a Peptoid and Protein Ligand discovery of nonenzymatic proteins can be accomplished through screening methods utilizing libraries comprising small molecules, peptides, and peptidomimetics. Incorporating peptoids, which are...

Paper Drop! Rpn-13 is the best protein :)
pubs.acs.org/doi/10.1021/...

ByeTAC: Bypassing E-Ligase-Targeting Chimeras for Direct Proteasome Degradation The development of targeted protein degradation by recruiting a protein of interest to a ubiquitin ligase to facilitate its degradation has become a powerful therapeutic tool. The potential of this approach is limited to proteins that can be readily ubiquitinated and relies on having a ligand with the various E3 ligases. Here, we describe a new methodology for targeted protein degradation that directly recruits a protein of interest to the proteasome for degradation. We generated bifunctional molecules that incorporate a small molecule ligand into a subunit on the 26S proteasome that recruits the protein directly for degradation. ByeTAC degradation requires binding to Rpn-13, a nonessential ubiquitin receptor of the 26S proteasome, and the protein of interest and does not have to rely on the E ligase cascade for ubiquitination. The ByeTAC methodology demonstrates the application of directly recruiting a protein to the proteasome via interactions with Rpn-13 for degradation.

ByeTACs is finally out in J. Med Chem. Congrats team! Can't wait to see how else we can use this degradation technology. @codyloy.bsky.social

pubs.acs.org/doi/10.1021/...

Discovery of RGS2-FBXO44 interaction inhibitors using a cell-based NanoBit assay Regulators of G protein signaling (RGS) proteins negatively regulate signaling through G protein-coupled receptors, and reduced RGS protein function i…

So happy to finally see this out! Check out our paper on identification of a small molecule inhibitor of RGS2 protein degradation! Thanks to all the authors for your hard work! www.sciencedirect.com/science/arti...

A friend drove two hours today for her breast cancer chemotherapy only to learn it was canceled due to NIH cuts. Clinical trial ended midstream. No treatment, no restart, no plan, no information. Her bro-in-law's chemo was also canceled.

Congratulations Breanna Zerfas and teams at DFCI on this linkerless PROTAC degrading and ER-stress transmembrane protein IRE1α with CRBN!
pubs.rsc.org/en/content/a...

Immunoproteasome as a Target for Prodrugs Immunoproteasome (iCP) is a proteasome isoform that is expressed under inflammatory conditions such as cytokine interferon-γ exposure. The iCP has different catalytic subunits other than the standard CP (standard core particle), allowing the production of major histocompatibility complex class I (MHC-I) compatible peptides for eventual T-cell activation. We have previously reported the design of a fluorescent probe that monitors iCP activity in cells called TBZ-1, and we applied TBZ-1’s iCP recognition sequence for prodrug release into iCP-active cells. Here, we demonstrate a proof-of-concept of the iCP as a prodrug release enzyme. The “payload” we utilized was a toxic moiety, doxorubicin, and a degrader for transcription factor, BRD4. Both examples show that iCP activity is required to elicit cell death or degradation of BRD4. This report highlights that the iCP is a viable prodrug target, and its activity can be used to release a variety of cargo in cells expressing the iCP.

Really proud to have this out in J Med Chem! Congrats to Christine and @codyloy.bsky.social
pubs.acs.org/doi/10.1021/...

Can it be done?!??!?!

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

Stand up for Science 2025. 12 pm class and lab walkout. March 7 2025 Washington DC and nationwide. Science is for everyone. Walk to Physical Sciences Quad.

UC Irvine

I got laid off today, with the rest of 18F.

18F was an elite federal software shop. We made gov't websites work better, more efficiently for the American people. We saved taxpayers from getting screwed over by contractors. And were fired for it.

We made this website to tell our story:
18f.org

Cell biology of host-pathogen interactions Microbial infections lead to drastic changes in the architecture and metabolism of the host cell. The inaugural FEBS EMBO Cell Biology of Host-Pathogen Interaction Advanced Course explores the mechan…

Host and pathogen aficionados:
Join us in Blois!- registration deadline 1st March- Please RP-
meetings.embo.org/event/24-hos...

Trump's illegal NIH cuts mean cancer researchers would be laid off, sick kids going without treatment, and more. These cuts would be DEVASTATING for lifesaving research.

Some Republicans have said they agree—but they just blocked my amendment to reverse Trump's NIH cuts anyway.

Flyer for Weill Institute Emerging Scholars Symposium at Cornell University, with QR code at bottom to obtain more information

Some good news: applications are open for the Weill Institute Emerging Scholars Symposium @ Cornell! Senior PhD students and, now, postdocs interested in networking & presenting their work in cell & molecular biology at Cornell should apply by Apr 14. Please repost! wicmb.cornell.edu/emerging-sch...

Were you fired by President Trump? | House Committee on Science, Space and Technology The House Committee on Science, Space and Technology

The Democrats on the House Science Committee have set up a website to collect stories from fired federal employees, anonymously if desired democrats-science.house.gov/sciencefirings

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

Black chemists you should know about These inventors, educators, and unsung heroes changed lives through their work in chemistry

Black chemists you should know about: These inventors, educators, and unsung heroes changed lives through their work in chemistry.

cen.acs.org/people/profi...

#BlackinChem #BlackHistoryMonth #chemsky🧪

Donald Trump and Elon Musk’s idea of efficiency is stopping research on curing cancer.

Arthur C. Cope Postdoctoral Fellowship in Organic Chemistry - American Chemical Society The Arthur C. Cope Postdoctoral Fellowship (CPF) of the American Chemical Society (ACS) is a two-year postdoctoral fellowship awarded yearly to Ph.D. candidates or postdoctoral researchers within their first two years of pursuing postdoctoral research in organic chemistry.

The Arthur C. Cope Postdoctoral Fellowship is a 2 year program designed to recognize outstanding achievements and foster innovative research in organic chemistry in the U.S. Fellows will receive $85,000 annually. Nominations are open until April 1.

zurl.co/81b5j

NIH In Your State - United For Medical Research Select a state on the map to see the impact of NIH funding across America.

If you would like to see how much economic activity and grants and how many people are employed through NIH in your state, just use this handy website.

And then contact your Congressional Rep and tell them to prioritize NIH. www.unitedformedicalresearch.org/nih-in-your-...

Welcome to UCI!!

Kim Lab at UC Irvine Visit the post for more.

Hello Bluesky friends! I am a #newPI starting at UC Irvine in April, interested in gene regulation and functional genomics in stem cell models of development (esp neural crest). We are hiring at all levels – please reach out/spread the word! sskimlab.org

Graduate Research Symposium (GRS) - ACS Division of Organic Chemistry The Graduate Research Symposium (GRS) provides opportunities for graduate students in organic chemistry to interact with leaders in the field.

The DOC Graduate Research Symposium (GRS) will take place at the San Diego State University July 17-20, 2025. Graduate students get to interact with leaders from academia, industry, funding agencies and publishers.

Applications are due on March 11th

zurl.co/rBH7y

Starting 2025 off with a review about degrons in @rscmedchem.bsky.social. Congrats Tim!

pubs.rsc.org/en/content/a...

Save the Date for the Inaugural DOC-EWOC Virtual Symposium on January 8th, 2025 @3pm EST featuring Professor Seunghyun Sim!
@organicdivision.org

Watch for free at:
YouTube: orgn.link/watch
Zoom: orgn.link/vs-zoom
Thank you to @BeyondCCHF for hosting
#ChemSky

Synthesis and Application of a Versatile Immunoproteasome Activity Probe The ONX-0914-alkyne probe described here allows for the conjugation to a variety of fluorophores through click chemistry. It can then be used to visualize immunoproteasome activity in gel-based, micr....

New #ChemBioChem paper by the @traderlab.bsky.social:

"Synthesis and Application of a Versatile Immunoproteasome Activity Probe"

chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/...

Can colleagues amplify this appeal to journals and journal editors to open accounts on Bluesky, please? @MicrobioSoc @TrendsMicrobiol @CellCellPress @JBacteriology @jbiolchem @Nature @ScienceMagazine @PNASNews @MolMicroEditors @NAR_Open @NatureMicrobiol @NatureComms @ASMicrobiology 🙏
🦠🧪🧫🧬

Thanks @blakerpeterson.bsky.social for giving an awesome seminar today #UCIPharmSci. Pacific blue dye for the win!