PAIN REPORTS SOCIAL GENERIC

Clendenen et al. find that patients with osteoarthritis have increased anandamide before surgery which decreases after surgery. Postoperative anandamide levels are associated with long-term pain resolution after surgery. Learn more in #PainReports bit.ly/41FBNV3

Li et al. find that individuals with higher adverse childhood experiences scores were more likely to develop pain and experience multiple pain sites over time, highlighting the importance of mental health interventions. Learn more in #PainReports bit.ly/3MF3k54

Among people who regularly use cannabis, Bush et al. find that cannabis has significantly higher relative reinforcing efficacy in those with greater clinical pain in the hypothetical marijuana purchase task. Learn more in #PainReports bit.ly/3OqH8vZ

The April issue of #PainReports is now available! Catch up on all the latest pain research at bit.ly/4tw8RKW

Kaneko et al. find that pregabalin modulates intracellular Ca2+ homeostasis by increasing Ca2+ extrusion activity via the plasma membrane Na+–Ca2+ exchanger in Merkel cells. Learn more in #PainReports bit.ly/4ruK4qb

Schalinski et al. find that childhood maltreatment, trauma, and trauma-related symptoms contribute to pain in individuals with a history of Residential Youth Care, with posttraumatic stress disorder and dissociation as potential mediators #PainReports bit.ly/4aZvuAY

In their pilot study of young adult women, Beal et al. find that negative affect, not maltreatment or violence exposure per se, was associated with increased pain; larger studies are needed to confirm. Learn more in #PainReports bit.ly/3OqDGl5

Walker et al. argue that equitable pain care requires integrating awareness of social conditions and structural inequities with clinician reflection and coordinated action across healthcare, communities, and policy. Learn more in #PainReports bit.ly/4rup1E6

Firima et al. assert that the elevated prevalence of chronic pain and high-impact chronic pain, associated with chronic conditions, supports the need for integrative chronic care involving pain management. Learn more in #PainReports bit.ly/4rup174

Pengpid et al. explored what influences the number of pain sites (NPS) and multisite pain (MSP) in Thai adults aged 80 and older, highlighting the complex interplay of social, economic, and health factors in pain management for the elderly #PainReports bit.ly/3Mw915l

Although individuals with upper or lower limb nerve injuries, treated either nonsurgically or surgically, face a higher risk of using pain medication, Dahlin et al. find that surgical treatment reduces that risk. Learn more in #PainReports bit.ly/4rup0jw

A clinical prediction model developed by Kjønø et al. to predict high health care utilization among people with spinal disorders in secondary care performed well upon internal and external validation. Learn more in #PainReports bit.ly/4ruoZMu

Using a traditional transauricular vagal nerve stimulation paradigm, De Herde et al. found no pain modulation or other effects. This highlights the necessity to inquire for optimal stimulation parameters. Learn more in #PainReports bit.ly/4tPYDGu

Wilderman et al. propose the “integral of pain relief” as a value that combines the approximate percentage and duration of pain relief to compare the efficacy of different treatments. Learn more in #PainReports bit.ly/4ruoYYW

Lopez et al. find that nearly 40% of adults in the United States (102M people in 2022) experienced pain requiring treatment with prescription medication: 80M and 29M with acute or chronic pain, respectively. Learn more in #PainReports bit.ly/4tFPzUt

Mosch et al. find that patients with fibromyalgia report self-perceived worsening of pain but no longitudinal change of pain scores. Pain severity is predicted through multiple psychosocial factors. Learn more in #PainReports bit.ly/4ar34zH

Han et al. present findings from 2 large and diverse US databases, All of Us and Epic Cosmos, indicating a higher pain prevalence among women in the United States. Learn more in #PainReports bit.ly/4rszL5W

Scarlatti et al. identify association between a neural signature of reward feedback and psychosocial signatures, with the comorbidity between pain and depressive symptoms, and between pain and anxiety symptoms. Learn more in #PainReports bit.ly/4rqJ0mX

Yamanaka et al. find that 3-Nitrotyrosine modulates excitatory and inhibitory synaptic transmission in the spinal dorsal horn by inhibiting GABA receptor activity, implicating its role in pain modulation. Learn more in #PainReports bit.ly/4auqeno

Zhao et al. find that boldine inhibits glia activation and reduces neuropathic pain after peripheral nerve injury. Learn more in #PainReports bit.ly/4azLgkV

McPherson et al. find that low-frequency, submotor threshold intraspinal microstimulation leads to a lasting increase in the spatial spread of nociceptive sensory-evoked activity, including after spinal cord injury. Learn more in #PainReports bit.ly/4cpSnyz

Haid et al. find that autistic adults assigned female at birth reported high rates of pain-related anxiety that were associated with generalized anxiety and pain interference in their lives. Learn more in #PainReports bit.ly/3NMgGN9

Teichmüller et al. find that spousal empathy and validation were associated with beneficial pain-related and relationship outcomes in chronic pain couples across most studies. The opposite was true for invalidation. Learn more in #PainReports bit.ly/4alApfh

Picañol et al. find evidence supporting Ziconotide’s analgesic promise, but adverse effects and study limitations temper confidence, underscoring the need for rigorous trials before broad clinical adoption. Learn more in #PainReports bit.ly/4qXINrh

Morgan et al. explore over 101 mechanisms of opioid tolerance, highlighting the complexity of identifying specific neural pathways involved and offering solutions to improve study designs. Learn more in #PainReports bit.ly/45F750G

Szmerling et al. assert that a multisite, multidisciplinary analgesic stewardship program may lead to better opioid prescribing at discharge and potentially clinically meaningful reductions in readmission. Learn more in #PainReports bit.ly/45FHpRv

Gaydos et al. find that interleukin-1β and Interleukin-6 are linked to the chronic pain experience: IL-6 is associated with physical symptoms, whereas IL-1β is associated with fear-avoidance and depressive symptoms. Learn more in #PainReports bit.ly/4qNQ6Sc

Guo et al. review the specific mechanisms involved in the regulation of neuropathic pain by 3 noncoding RNAs (ncRNAs) and explore the feasibility of using ncRNAs as therapeutic targets for neuropathic pain. Learn more in #PainReports bit.ly/4qXIMDJ

Tantawy et al. find that lacosamide alleviates oxaliplatin-induced peripheral neuropathy by effectively reducing neuroinflammatory biomarkers and improving 12-item neurotoxicity questionnaire scores, similar to duloxetine. Learn more in #PainReports bit.ly/4qXIMnd

Hattori et al. find that pain and disability in patients with subacromial pain syndrome are associated with pain sensitization rather than with rotator cuff-related factors. Learn more in #PainReports bit.ly/4qK653J