Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA) - BMC Medicine Background Sarcopenia, the age-related loss of skeletal muscle mass and function, has been linked to adverse health outcomes. Cross-sectional associations have been observed between skeletal and cardi...

Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
link.springer.com/article/10.1...

Effects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta‐Analysis Background Despite ongoing interest in anabolic therapies for sarcopenia and cachexia, pharmacological interventions are being developed to counteract age- and condition-related losses of muscle mas...

Effects of Nandrolone Decanoate on Muscle Strength, Body Composition and Bone Density: A Systematic Review and Meta-Analysis

onlinelibrary.wiley.com/doi/10.1002/...

Have you submitted your abstract yet?
Don't miss the chance to present your #research at the 22nd #EuGMS Congress in the beautiful city of Lille!

"Optimising Function: A Key to Healthy #Ageing".

🔗 Submit here: www.eugms2026.com

#Geriatrics #Aging #Health #Care #OlderPersons #Science #MedSky

The effects of bed rest on cardiometabolic health: A systematic review and meta‐analysis Horizontal bed rest (HBR) and head-down tilt (HDT) are models of physical inactivity. In this systematic review and meta-analysis, we aimed to quantify changes in cardiometabolic outcomes during HBR ...

The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis

physoc.onlinelibrary.wiley.com/doi/full/10....

Effects of bed rest and immobilization on intramuscular and intermuscular adipose tissue: A systematic review Muscle disuse caused by bed rest and immobilization is associated with muscle atrophy and insulin resistance, which might be related to increases in intramuscular fat (IntraMAT) and intermuscular fat...

Effects of bed rest and immobilization on intramuscular and intermuscular adipose tissue: A systematic review

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis AbstractIntroduction. The global burden of heart failure (HF) is rising, with a shift towards more cases of heart failure with preserved ejection fraction

Mortality and heart failure hospitalizations in heart failure with preserved ejection fraction compared to heart failure with reduced ejection fraction: a systematic review and meta-analysis @livhp.bsky.social @livuniresearch.bsky.social url: academic.oup.com/eschf/articl...

Skeletal muscle morphology and metabolism in heart failure compared to healthy controls: a systematic review and meta-analysis

journals.physiology.org/doi/abs/10.1...

Systemic Challenges in Sarcopenia Research: Implications for Meta‐Analytic Reliability and Clinical Translation Sarcopenia, the age-related decline in skeletal muscle mass and strength, is a growing public health concern, yet several meta-analyses may be unreliable due to methodological and systemic challenges...

Systemic Challenges in Sarcopenia Research: Implications for Meta-Analytic Reliability and Clinical Translation

onlinelibrary.wiley.com/doi/10.1002/...

Glucagon-like peptide-1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Probiotics, prebiotics, and synbiotics to counteract sarcopenia: where are we now and what challenges need to be faced?

www.cambridge.org/core/journal...

Food matrix in the context of muscle and whole-body protein synthesis: a scoping review - Nutrition & Metabolism Background Understanding the impact of food matrix, the combination of nutrients, bioactive compounds, and physical characteristics in a food product, on muscle protein synthesis (MPS), could provide ...

Food matrix in the context of muscle and whole-body protein synthesis: a scoping review

link.springer.com/article/10.1...

Recruiting a comp PDRA for the lab 🚨

Working on multiple projects using integrated multi omics in bulk & single cell level

Passion for data, coding, bioinformatics & keen to lead our labs comp workflow

12 months in first instance but extendable for further 19 months

my.corehr.com/pls/coreport...

Top Cited Review Article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions

Michael D. Roberts, et al.
https://ow.ly/moMh50Xe5nU
#hypertrophy #myofiber

The effect of bed rest, unilateral limb immobilization and head‐down tilt on muscle protein synthesis: A systematic review and meta‐analysis Muscle disuse leads to muscle atrophy and a decrease in muscle function that is primarily driven by reduced muscle protein synthesis (MPS). The aim of this systematic review and meta-analysis was to ...

The effect of bed rest, unilateral limb immobilization and head-down tilt on muscle protein synthesis: A systematic review and meta-analysis

physoc.onlinelibrary.wiley.com/doi/10.1113/...

Impact of Semaglutide on fat mass, lean mass and muscle function in patients with obesity: The SEMALEAN study

dom-pubs.onlinelibrary.wiley.com/doi/10.1111/...

14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

Little under a week left to apply for this position to come and lead some cool experiments in muscle biology in London!

Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2‐adrenergic signalling Abstract figure legend This randomized controlled study investigated the effect of a 2 week treatment cycle of either oral clenbuterol or placebo in healthy young men. We found that clenbuterol: (1) ...

Clenbuterol induces lean mass and muscle protein accretion, but attenuates cardiorespiratory fitness and desensitizes muscle β2-adrenergic signalling
physoc.onlinelibrary.wiley.com/doi/10.1113/...

Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake - GeroScience Frailty, often linked to sarcopenia, involves reduced muscle strength and mass. While sarcopenia has multiple causes, impaired muscle protein synthesis may contribute. Leucine and resistance training ...

Resistance training, but not leucine, increased basal muscle protein synthesis and reversed frailty in older women consuming optimized protein intake

link.springer.com/article/10.1...

Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity? Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been pivotal for obesity treatment, achieving 15–25 % weight loss over 12–24 months, but qu…

Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?
www.sciencedirect.com/science/arti...

In this article, we provide a rationale behind the risk of sarcopenic obesity due to weight cycling with GLP-1 receptor agonists...

"Weighing the risk of GLP-1 treatment in older adults: Should we be concerned about sarcopenic obesity?"

www.sciencedirect.com/science/arti...

- The Ana-IGF-1 low group showed significantly higher IL-6 levels at baseline and significantly shorter overall survival compared to the Ana-IGF-1 high group

- Adverse events were comparable between the 2 groups (any grade: 100% vs 100%; grade ≥3: 88.9% vs 90.0%)

When the anamorelin group was divided into 2 groups by the median serum IGF-1 level after 1 week (Ana-IGF-1 high and Ana-IGF-1 low groups), the SMI in the latter group showed a decreased tendency (p = 0.14).

- Serum IGF-1 levels in the anamorelin-treated group were higher after 1 week

- Changes in IGF-1 and SMI positively correlated in the anamorelin group (R = 0.61)

Patients with metastatic urothelial carcinoma were randomized to anamorelin (100 mg orally) (Ana; n = 20) or control (systemic chemotherapy only) (n = 18) groups for 12 weeks.

Gemcitabine + cisplatin or gemcitabine + carboplatin therapy was performed as a systemic chemotherapy.

Efficacy and safety of anamorelin in patients with metastatic urothelial carcinoma receiving systemic chemotherapy: a randomized controlled study

academic.oup.com/oncolo/artic...

Treating Sarcopenic Obesity in the Era of Incretin Therapies: Perspectives and Challenges Sarcopenic obesity, a subtype of obesity, is marked by reduced skeletal muscle mass and function, or sarcopenia, and poses a significant health challenge t

Treating Sarcopenic Obesity in the Era of Incretin
Therapies: Perspectives and Challenges

diabetesjournals.org/diabetes/art...

Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model In this article, Parafati, Malany, and colleagues show that microgravity altered contractile response and slow-twitch protein levels in a lab-on-chip muscle model on the ISS. Electrical stimulation en...

Microgravity accelerates skeletal muscle degeneration: Functional and transcriptomic insights from an ISS muscle lab-on-chip model
www.cell.com/stem-cell-re...

Assessing the composition of myofibrillar and muscle connective protein fractions within skeletal muscle tissue It has been suggested that different nutritional stimuli are required to augment myofibrillar versus muscle connective protein synthesis rates. To study such different aspects of skeletal muscle re...

Assessing the composition of myofibrillar and muscle connective protein fractions within skeletal muscle tissue
www.tandfonline.com/doi/full/10....

- Results were overall lacking in regards to resistance or aerobic exercise and IntraMAT (due to the low number of studies).