Looking forward to talking to British Neuropathological Society and Edinburgh Neuroscience on Tue 14th April (1-2pm):
'The Overwhelm Trap'
What is overwhelm? Why does it happen? How to avoid, or get out of it
edinburghneuroscience.ed.ac.uk/the-overwhel...
See also www.sciencewithoutanguish.com
Congratulations to Laura Carlton and Emma Wilson on these exciting findings, their first primary research articles as first and senior author respectively. Also thanks to Heba Morsy for in silico analysis of promoter sequences.
We look forward to working constructively with reviewers.
Importance: These findings will support disease association studies link programmed axon death to specific human diseases. It is essential to move beyond the limitations of animal models and work directly in humans to understand where best to apply drugs blocking programmed axon death.
4/5
(2) Several rare variants lower hNMNAT2 expression. These are likely to increase risk of programmed axon death
(3) One arose in an ALS patient in Project MinE
(4) A common variant in the SARM1 promoter significantly increases expression, also potentially raising the risk of programmed axon death
3/5
SARM1 is a protein that drives axon degeneration. NMNAT2 suppresses its activity to keep axons healthy. Their expression levels are fundamentally important to axon health.
Key points:
(1) Identification of distinct regions that boost and suppress hNMNAT2 and hSARM1 expression
2/5
Delighted to announce the latest preprint from our amazing team: www.biorxiv.org/content/10.6...
Laura Carlton and Emma Wilson report luciferase mapping of the human NMNAT2 and SARM1 promoters, naturally-occurring human gene variants within them and their functional consequences.
1/5
Congratulations @selinawray.bsky.social!
Today in Science Without Anguish:
'It's not what you know, it's who you....trust'.
When knowledge is really trust in disguise. And not absolute but greyscale.
Why knowing this helps us cope when our knowledge is challenged. www.sciencewithoutanguish.com/blog/its-not...
Today in Science Without Anguish: how we handle experiences that don’t fit our mental map. The many ways that cognitive dissonance plays out in academic research and the problems this causes us. www.sciencewithoutanguish.com/blog/to-chan...
I reviewed my success rate for an ECR mentoring talk. Surprisingly I noticed the funding decisions on proposals made 15-25y ago bore little resemblance to which had the best plans with benefit of hindsight. A big lesson in what rejections mean and don’t mean. But they still hurt!
Thanks for sharing. The more we do that, the easier it gets for us all and the fewer great young scientists we lose from research because of total misunderstanding about what rejection does and doesn’t mean.
Science WITH Anguish?
Grant rejection today. It never stops hurting no matter how successful or how many you dealt with before (this is no. 57). Thanks to my team for helping me handle it today. 😀 Tomorrow we go on.
ECRs dealing with rejection: you are not alone! Hot tip: saying this helps me too!
Today in Science Without Anguish: Is blame bringing you down?
How we shackle ourselves by blaming others, also degrading workplace culture and raising our stress levels.
But can we avoid it without blaming ourselves instead?
www.sciencewithoutanguish.com/blog/is-blam...
Burnout. @lizandmollie
Today in Science Without Anguish: how failing to notice when the wind is behind us makes us believe the world is against us when things don’t go our way.
www.sciencewithoutanguish.com/blog/im-good...
In this week’s Science Without Anguish:
‘Short cuts to lost potential’.
How confusing the simplifications we make to understand the world with the real thing can lead us astray.
www.sciencewithoutanguish.com/blog/the-sho...
Science Without Anguish series 3
This week: the mistakes we make understanding our world that we would never make in our science
www.sciencewithoutanguish.com/blog/heurist...
Coming up next week: how what grabs our attention most and first impressions skew our thinking.
This week in Science Without Anguish: how simplifying our view of the world based on limited evidence can lead us astray. www.sciencewithoutanguish.com/blog/heurist...
Science Without Anguish series 3: out now!
www.sciencewithoutanguish.com/blog/dont-be...
Could clear thinking about research life make it easier?
Next week: The short cuts our minds use to make sense of the world and the problems this can lead to.
Science Without Anguish Series 3 in out:
Don’t believe everything you think!
Confusing our mental shortcuts with reality.
Excusing ourselves but blaming others.
Not realising we’re doing it and making life harder for ourselves in the process.
www.sciencewithoutanguish.com/blog/dont-be...
How much of what we think we ‘know’ is just trust in the person that told us?
And what price do we pay for confusing the two?
Coming soon in Science Without Anguish:
‘Don’t believe everything you think!’
sciencewithoutanguish.com
Starts Monday 22nd Sep
Science Without Anguish Series 3 starts Monday 22nd
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
Science Without Anguish Series 3 starts Monday 22nd
'Don't believe everything you think!'.
sciencewithoutanguish.com
How heuristics & biases make our research lives more difficult and ways to reduce this. Stereotyping, snap judgements, confirmation bias, attribution errors, negativity bias….
Very exciting opportunity here to work with former member of our group and rising star @andrea-loreto.bsky.social Highly recommended!
Hi @andrea-loreto.bsky.social, welcome to BlueSky!
Morale?
I have colleagues there who are leaving NIH for jobs in China, France, Canada, industry, or retiring early.
That’s real.
Great to see @maxstetina.bsky.social here.
Max did a very productive internship with us last year looking at evolutionary conservation of SARM1 and NMNAT2.
Job alert!
Cambridge Neuroscience Administrator (Part Time, Fixed Term)
www.jobs.cam.ac.uk/job/51034/
“Smile!”, they said, “Things could be worse.”
So I smiled …. and they did get worse.
😢
I wrote an Article about the Netflix drama, Adolescence.
Free version here
archive.is/goNeQ