I guess, what I meant is whether for a given gene, the human/chimp/orang tree could be used to correct the human/chimp/gorilla tree.

That was very helpful. Q: would there be more incomplete lineage sorting events when examining human/chimp/gorilla trios than human/chimp/orangutan trios because the time between the two speciation events is greater in the latter? Can you use one tree to correct the other?

I was just sent this: rnaverse.com ... an AI for lncRNA research developed by J. Rinn and Google. I tried asking it for documentation but didn't get any. I asked it what % of the genome was transcribed into functional lncRNAs, it replied likely 1-2%. Not bad. At least we know it is not panglossian.

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

2nd call for postdoc positions in the lab. Get in touch for more information or simply apply here: mbg.au.dk/en/news-and-...

The rise of China in publishing scientific papers.

www.nber.org/digest/20260...

Diese erstklassige Rede
von Carl Sagan 🖤
zur Klimaerwärmung
hielt er übrigens
am 9.2.1990.

Listen please:

Why Scientific Inquiry Must Not Be a Slave to Our Politics — The Palazzo Lab As scientists we are supposed to be open to all forms of inquiry, even if they may expose inconvenient truths. But on certain topics, we're not. Not because the questions are scientifically uninterest...

My newest blog post is up: Why Scientific Inquiry Must Not Be a Slave to Our Politics

The Promoter-Proximal Pause: A Decision Point Governing RNA Polymerase II Fate A signature feature of transcription on most genes in multicellular animals is that RNA polymerase II (RNAPII) piles up approximately 50 bases downstream of the start site at the promoter-proximal pau...

Happy to share that David and I have a new review out in @annualreviews.bsky.social of Biochemistry!

We break down Pol II pausing, its evidence in vitro/in vivo, and its two key fates which are in kinetic competition: pause release vs premature termination.

www.annualreviews.org/content/jour...

Opinion | I Saw Something New in San Francisco

I Saw Something New in San Francisco
www.nytimes.com/2026/03/29/o...

Congrats!

Check out the final version of this work, out today! @natcomms.nature.com www.nature.com/articles/s41...

We should put understanding reality ahead of wanting it to be a certain way. Our politics shouldn’t assume or require reality to align with what we want.

Your politics shouldn’t be 100% contingent on your beliefs about how the world is. That framework is fragile, and easily dismissed if those beliefs turn out to be wrong. Acknowledging reality matters, but what matters more is grounding your politics in goals like freedom, fairness, or meritocracy.

The Most Dangerous Idea In Academia (and why researchers must be free to study it)

THIS. As academics, we must protect free inquiry, even of topics we might disagree with. maartenboudry.substack.com/p/the-most-d...

#RNAsky

Misinformation about mRNA vaccines is shaping legislation & policy. We wrote this for anyone who needs a rigorous, citable resource to push back against false narratives. #mRNA #GetTheMessage #Vaccines #HHS #FDA #CDC

rnajournal.cshlp.org/content/earl...

A French general remarked, “Joining President Donald Trump’s war is like buying a discounted ticket for the Titanic after it had already hit the iceberg.”

Transposon Ecology and the Octopus Genome Transposable elements (TEs) are mobile strands of DNA prevalent in octopus genomes. TE activity in the octopus brain might reflect an organism-beneficial role in cognition; or could be a deleterious ...

#TEsky Another paper in our TE ecology exploration of the Octopus out in BioEssays. Types of niches for TEs and what that could mean for their expression in neural tissue doi.org/10.1002/bies...

Good work Tyler, and my congrats to Stefan and all the other coauthors.

Hi Arlin, I would like to attend, but can't DM you (DMs require that both sides follow each other).

The Genotype-Phenotype Map A comprehensive map of genetic associations, colocalizations, and rare variant analysis across thousands of traits and molecular measurements.

Excited to announce the release of The Human Genotype-Phenotype Map!

* We processed 16k complex traits & 2.7M QTLs
* Turned 49.3M significant colocalizations into 97k distinct groups
* Upload your own GWAS to compare against all data

Website: gpmap.opengwas.io
Preprint: tinyurl.com/3ktsr9hw

“This is not efficiency. This is not streamlining. This is the systematic elimination of scientific stewardship at the world’s largest biomedical research funder.”

"First assume a spherical seal ..."

I am leaving the Washington Post to join a new journalistic venture backed by Politico founder Robert Allbritton that will be both the hometown publication the D.C. region sorely needs and a scrappy and fearless national news organization. I hope you'll join us.

... Are there any hints of endoplasmic-reticulum shaping proteins in the Asgards (Reeps and reticulons?)

Great overview! There is so much progress in this field. I guess one (of many) issues that it seems like we do not have a good grasp is the origin of the endomembrane system and the nucleus (I guess M. Fields and M. Rout have done some analysis on the origin of the NPC). ...

Having a hard time keeping up with the fast-moving field of origin of eukaryotes/Asgards archaea? Our new perspective article can help, we review the status of research over the last decade and where it's going.

The archaeal roots of eukaryotic life

www.pnas.org/doi/10.1073/...

Another thing that is weird/interesting, is that the authors provide evidence that METTL3 has an increased affinity for m6A modified RNA than unmodified RNA. I need to talk to some enzymologists to figure out what that means.

N6-adenosine methylation enhances nuclear mRNA export through METTL3 and NUP93 - Nature Cell Biology Lee et al. report a mechanism regulating mRNP export mediated by N6-adenosine methylation, METTL3 and NUP93 with potential implications for nephrotic syndrome and other human diseases.

I'm not sure what to make of this. The mechanism seems a bit goofy (that m6A increases the hydrophobicity of mRNA, increasing NPC-association? really?) www.nature.com/articles/s41...