Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells Genome-wide CRISPR activation and knockout screens in primary human CD4+ T cells systematically identify host proviral and antiviral factors modulating HIV infection, including the strongly antiviral factor PPID, which is shown to bind HIV capsid and reduce its nuclear import.

Now online! Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells

2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity An evolutionarily conserved CBASS transmembrane effector—ancestral to the mammalian cGAS-STING pathway—is activated by 2'3'-cGAMP to assemble into membrane-spanning filaments that disrupt membranes via a newly defined mechanism of vertical lipid shearing.

Now online! 2'3'-cGAMP-induced membrane shearing promotes broad antiphage immunity

Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade In 674 high-risk melanoma patients across five regions, the gut microbiome differs by region but remains stable during ICB treatment, and region-specific bacterial markers predict relapse.

Now online! Gut microbiome is associated with recurrence-free survival in patients with resected high-risk melanoma receiving adjuvant immune checkpoint blockade

B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism B cells regulate exercise capacity through immune-independent liver-muscle metabolic signaling, and B cell deficiency limits muscle performance. Mechanistically, B cell-secreted TGF-β1 increases hepatic glutamine-to-glutamate conversion, raising glutamate in blood and muscle. This promotes muscle calcium signaling and mitochondrial function, positively regulating exercise capacity.

Now online! B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

p53 safeguards chemical reprogramming of human somatic cells toward pluripotency In contrast to its barrier role in transcription factor-driven reprogramming, p53 is indispensable for efficient chemical reprogramming, where p53-competent cells preserve their genomic integrity to achieve pluripotency, whereas p53-deficient cells are selectively diminished.

Now online! p53 safeguards chemical reprogramming of human somatic cells toward pluripotency

A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes This study provides a paradigm for how the vast chemical diversity inherent in agricultural crops can be screened to identify compounds that deter insect disease vectors and pests. Such a “phytoscreen” identifies a garlic compound that deters mating and egg laying in mosquitoes and flies.

Now online! A phytoscreen identifies a garlic compound as a deterrent of mating and egg laying in Drosophila and mosquitoes

Predicting competition and substrate preferences for targeted microbiome alteration Translation profiling reveals how microbes allocate cellular resources in complex communities. The microbial interaction and niche determination (MIND) framework links functional prioritization to competition and substrate preferences, enabling the rational design of targeted prebiotic and probiotic interventions to selectively manipulate microbiomes across environmental and host-associated systems.

Now online! Predicting competition and substrate preferences for targeted microbiome alteration

Cell death in cancer The expanding landscape of cell death programs has transformed cancer biology and opened exciting therapeutic frontiers. This review maps how these pathways drive cancer progression and therapy respon...

And a Review on cell death in cancer www.cell.com/cell/fulltex...

Cancer neuroscience: The past, the present, and the road ahead The multilayer crosstalk between cancer and the nervous system not only shapes cancer development but also influences systemic human physiology that governs patient outcomes. This review outlines over...

Also featuring a Review on cancer neuroscience www.cell.com/cell/fulltex...

Hallmarks of setting up a successful patient advocacy group Patient advocacy has the potential to contribute to effective cancer care with real-world impact, regardless of a country’s socioeconomic status. Here, we asked representatives of patient advocacy gro...

Hallmarks of setting up a successful patient advocacy group www.cell.com/cell/fulltex...

Hallmarks of Cancer: How did it inspire you? In this Voices piece, we asked researchers to reflect on how the Hallmarks of Cancer have shaped their career paths, their research directions, and their broader perspectives on cancer. Their reflecti...

Featuring insights from researchers on the impact of Hallmarks of Cancer www.cell.com/cell/fulltex...

New issue alert👉https://cell.com/cell/current
On the cover: For the Hallmarks of Cancer's 25th anniversary, the cover illustrates its enduring impact across the cancer research community, uniting scientists, clinicians, patients, and educators to drive progress.

The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis (Cell 188, 4567–4585.e1–e12; August 21, 2025)

Now online! The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition Opposing oncogenic and tumor-suppressive forces establish a progenitor-like state that builds a self-reinforcing niche to drive benign-to-malignant transition in pancreatic cancer models. Disruption of p53 activity or KRAS inhibits malignancy by collapsing the niche.

Now online! Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition

Bringing the genetically minimal cell to life on a computer in 4D (Cell 189, ▪▪▪–▪▪▪.e1–e21; April 30, 2026)

Now online! Bringing the genetically minimal cell to life on a computer in 4D

Join us in China for the Cell Press Symposia: Biological function in 3D: Structure, dynamics, and AI in partnership w/ SUSTech. Explore how emerging tech & AI reveal biology from molecules to organisms.

#CS3Dbiologicalfunction26
http://dlvr.it/TS2xnN

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression The EMF-inducible gene switch (Ei) platform provides precise spatiotemporal control of gene expression through Cyb5b-mediated calcium oscillations. This system enables Ei-OSK-driven in vivo rejuvenation reprogramming, Ei-mutant APP expression in the context of Alzheimer’s disease, and behavioral rescue in depression through Ei-Tph2-mediated neuromodulation.

Now online! Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression

The spatiotemporal dynamics of postnatal vascularization in the mouse brain Whole-brain tissue clearing and spatial transcriptomics were applied to map postnatal vascular development in the mouse brain, identifying three coordinated phases that link vascular growth to neuronal maturation.

Now online! The spatiotemporal dynamics of postnatal vascularization in the mouse brain

Cell Press Symposia: Taking programmed cell death from mechanisms to interventions

Hear directly from the organizers why this is a must-attend event for researchers working on all aspects of cell death and join them in Hangzhou, China, October 22–24, 2026

#CSCellDeath26 @cellpressevents.bsky.social
http://dlvr.it/TS21Hm

Rational design of Gi-biased CB1 agonist with reduced side effects Rational design of cannabinoid receptor agonists that uncouple therapeutic analgesia from unwanted on-target effects, establishing a blueprint for next-generation non-opioid therapeutics.

Now online! Rational design of Gi-biased CB1 agonist with reduced side effects

Microbes as architects of colonic patterning

Highlight of @cp-cell.bsky.social paper discovering regionalization of colonic epithelium depends on microbes, with proximal identity regulated by microbial nicotinic acid-induced PPARα activation in the epithelium.
www.cell.com/cell-host-mi...

Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers Rising early-onset cancers challenge existing frameworks for understanding and managing cancer. This perspective outlines a roadmap for addressing this challenge by advancing the discovery of cancer causes, cancer risk assessment, and cancer preventability characterization.

Now online! Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia (Cell 182, 1156–1169.e1–e7; September 3, 2020)

Now online! Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise Cellular senescence, defined by six major hallmarks, is a program that halts cell division while rewiring chromatin, metabolism, microenvironment sensing, and immune interactions to either suppress or promote cancer and is an exciting frontier for precision therapy.

Now online! Senescence in cancer: Hallmarks, paradoxes, and therapeutic promise

The MicrobeAtlas database: Global trends and insights into Earth’s microbial ecosystems MicrobeAtlas (www.microbeatlas.org) is an integrated, reference-based resource for truly planet-wide microbiomics, analyzing hundreds of thousands of microbial lineages across diverse environments, co...

And the MicrobeAtlas as an integrated, reference-based resource for planet-wide microbiomics
www.cell.com/cell/fulltex...

Planetary microbiome structure and generalist-driven gene flow across disparate habitats A planetary-scale analysis of over 85,000 metagenomes establishes a framework for exploring the structure and drivers of global microbial habitats, revealing that generalist species bridge ecological ...

A framework for exploring the structure and drivers of global microbial habitats
www.cell.com/cell/fulltex...

New approach methodologies for drug discovery New approach methodologies that are human-centered, such as stem cells, organoids, and in silico models, can span the full drug discovery pipeline—from disease modeling to efficacy testing—and hold pr...

A Review on human-centered new approach methodologies for drug discovery
www.cell.com/cell/fulltex...

Metabolite-gated vascular contractility switch: OXGR1 activation mechanism enables agonist therapy for rosacea erythema Xiao et al. identify α-KG as a rosacea-associated metabolite that activates the OXGR1-Gq-MYL9 axis in the vascular smooth muscle cells to boost contractility and suppress pathological vasodilation und...

Featuring a rosacea-associated metabolite that activates vascular smooth muscle cells to suppress pathological vasodilation
www.cell.com/cell/fulltex...

New issue alert👉https://cell.com/cell/current

On the cover: Bowhead whales were driven to near extinction during four centuries of commercial whaling. In this issue of Cell, Westbury et al. examine the genomic legacy of this exploitation and its implications for the species’ future

Complete biosynthesis of nicotine Glycosylation and deglycosylation complete nicotine biosynthesis by enabling stereoselective condensation of its two heterocyclic rings within a vacuolar membrane metabolon. This integrated biosynthetic and transport machinery is transferable to heterologous systems for efficient nicotine production and pest resistance.

Now online! Complete biosynthesis of nicotine