🔬Revelan factores potencialmente claves en la resistencia al daño de las células cancerosas 

👩‍🔬Un equipo del @cbm-csic-uam.bsky.social ha identificado factores que amenazan la supervivencia celular cuando falla la vigilancia, como ocurre en los tumores

➡️ http://tiny.cc/tves001

@cabimer.bsky.social @unisevilla.bsky.social @cbm-csic-uam.bsky.social @crick.ac.uk

🧬 Checkpoint mutants undergo gradual degradation of nascent DNA at replication forks, which is prevented in the absence of Rad51, Mus81, Rad5 and Exo1
🧪 Heterologous expression of human PrimPol or overexpression of Mre11 can counteract the aberrant processing of replication forks

📄 We identified Rad51, Mus81 and Rad5 to be involved in the irreversible replication fork arrest observed in yeast checkpoint mutants upon DNA damage, despite they are also required for normal fork progression or restart once the damage is removed

S-phase checkpoint protects from aberrant replication fork processing and degradation Abstract. Replication stress, a hallmark of cancer cells, is detected by checkpoint mechanisms that trigger a range of cellular responses. Among these, the

Excited to share my first PhD paper published in @narjournal.bsky.social! This project was led by amazing supervisor Belén Gómez González in @aguilerloop.bsky.social lab. Thanks to all colaborators of Blanco and Diffley teams. I hope you like it!
Now online here 👇🏼 academic.oup.com/nar/article/...

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.

Our latest study from my postdoctoral work has just been published in Science Advances!

Grateful to my mentor and collaborators who made it possible! @buissonlab.bsky.social @ucirvine.bsky.social

🔗 www.science.org/doi/10.1126/...

Glad to see our PACT preprint published in @naturecomms.bsky.social!

"Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA"

Another step forward in understanding innate immunity. @buissonlab.bsky.social

🔗 www.nature.com/articles/s41...