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Posts by Sylvia Erhardt

Little hut that looks a bit like a strawberry (green roof, red walls) selling berries and asparagus on the side of the road. Red and white striped umbrellas in front of of it.

Little hut that looks a bit like a strawberry (green roof, red walls) selling berries and asparagus on the side of the road. Red and white striped umbrellas in front of of it.

Waited for this all winter: The ‘Erdbeerhäuschen’ on my way to work is back! local berries 🍓 for breakfast from now on!

3 hours ago 4 0 0 0
Nice white butter cream cake with an image in the middle of a blue cartoon figure with blood shot eyes, an academic hat and the text: ‘you did it’

Nice white butter cream cake with an image in the middle of a blue cartoon figure with blood shot eyes, an academic hat and the text: ‘you did it’

Today’s tasteful celebratory cake of a successfully defended PhD thesis … congrats Aga!

18 hours ago 5 1 0 0
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John Gurdon (1933-2025) John Gurdon was a towering figure in developmental biology, respected and admired throughout the world. His discovery, made when he was a PhD student, that the nuclei of differentiated cells retain th...

Thank you to Jim Smith for writing about the legacy of #devbio giant and former Chair of @biologists.bsky.social's Board of Directors, Sir John Gurdon.

23 hours ago 10 4 0 0

there goes the central dogma, i guess. is nothing sacred anymore?

3 days ago 51 9 3 0
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Lucasfilm drops The Mandalorian and Grogu final trailer at CinemaCon The old protect the young, and then the young protect the old."

Lucasfilm drops The Mandalorian and Grogu final trailer at CinemaCon arstechnica.com/culture/2026...

3 days ago 9 2 1 2
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#StreetArt & #davidbowie #streetarteverywhere #buenosaires
2025

5 days ago 276 32 2 1
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Finally published at long last (at least in the pre-view version). Explore the wild and woolly world of archaeal histones! Interactive archaeal histone graph incluced rdcu.be/fdFjv. Congratulations to first author Shawn Laursen

5 days ago 69 27 3 0
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A belted galloway cow walking into the mist, towards a bold, unpredictable future.

A belted galloway cow walking into the mist, towards a bold, unpredictable future.

“So it was, on that misty morning, that Brenda set off for the capital. She knew not what she would find there, only that the time had come to move on - away from small-minded rural attitudes and people who called her ‘Oreo’ and ‘the wide panda’ - to seek a more fulfilling life.”

6 days ago 788 154 23 8

New preprint from the Bhalla Lab! Thread will be available later today!

5 days ago 8 2 0 0

They’re beautiful!

5 days ago 2 0 0 0
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Cohesin and its regulation promote monopolar kinetochore orientation at meiosis I in Arabidopsis The first division of meiosis is unique in its capacity to halve the ploidy of future gametes. To this end, one key innovation compared with mitosis i…

www.sciencedirect.com/science/arti...

2 weeks ago 11 6 1 2

Germ cells have their own versions of core transcription factors and fertility depends on them.
We're hiring a PhD student to figure out how! 📢
Fly genetics + proteomics + genomics. Fully funded.
Aarhus University 🇩🇰
Deadline May 1 👇

Please share with anyone who might be interested!

2 weeks ago 33 41 0 4
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"Chromatin organization in Asgard archaea: Histones, SMC complexes, and the archaeal roots of eukaryotic chromatin"
by Remus Dame & colleagues (@damelab.bsky.social)

"Understanding chromatin organization in Asgard archaea is key to understanding how eukaryotic chromatin evolved."

shorturl.at/6bLvx

3 weeks ago 22 10 1 0
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“Sakura” in Japan.
Cherry blossoms symbolize the fleeting nature of life, mortality, renewal, and spring in Japanese culture. ☺️

TT: ThaoThao
Yodo station, Kyoto

3 weeks ago 7386 1105 148 62
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Scientists watch sperm whales work as a team to assist a birth An unprecedented look at the birth of a sperm whale found that mother and calf were supported by other whales throughout the process.

An unprecedented look at the birth of a sperm whale found that mother and calf were supported by other whales throughout the process. n.pr/40THi23

3 weeks ago 887 210 17 48
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We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

4 weeks ago 53 49 0 0
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Some work life impressions of the week:

Huge-a&& KIT logo downtown, our new slogan #scienceforimpact (I like it)

Friday evening Campus North institute sunset panorama

Drosophila testes imaging for revisions with @erhardtlab.bsky.social lab, samples looking great! #FluorescenceFriday #latergram

4 weeks ago 1 1 0 0

Happy Birthday, Needhi🍹

1 month ago 1 0 1 0
A dual role for CTCF in development CTCF is an essential DNA binding protein whose absence leads to embryonic lethality. CTCF is primarily known for its role in 3D genome organization where its N-terminal domain interacts with cohesin to anchor chromatin loops. How CTCF facilitates proper embryonic development remains unclear, necessitating temporal control to resolve its stage-specific functions. By combining gastruloids, an in vitro model of embryonic development, with a degron system to rapidly deplete CTCF at defined timepoints, we show that early CTCF depletion impairs early gastruloid morphogenesis. Surprisingly, ATAC-seq and time-resolved RNA-seq revealed that differentiation was unaffected. CTCF binding is strongly enriched at promoters of downregulated genes. Re-expression of a CTCF variant with an N-terminal truncation, incapable of looping, was sufficient to rescue the expression of CTCF-promoter bound genes and the defects in morphogenesis. However, extended culture (up to 168 hours) of gastruloids reconstituted with N-terminal truncated CTCF led to their collapse. Our work shows that CTCF has a dual function in early mammalian development: at early stages CTCF regulates developmentally important genes through promoter binding, while at later stages its looping function is required for correct development. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, https://ror.org/0472cxd90, 637587, 865459 Dutch Research Council, https://ror.org/04jsz6e67, 016.161.316, VI.C.222.049 Dutch Cancer Society, https://ror.org/0368jnd28, N/A

🧵 CTCF is essential for embryonic development, but why has remained unclear. By combining gastruloids with a temporal degron system, we uncovered a surprising dual function — and it changes how we think about CTCF's role in development. 1/8 www.biorxiv.org/content/10.6...

1 month ago 112 55 7 4
Pink magnolia tree and blue sky!

Pink magnolia tree and blue sky!

A beautiful spring morning!

1 month ago 7 0 0 0
A scarecrow who has just watched Monty Python's The Holy Grail for the first time.

A scarecrow who has just watched Monty Python's The Holy Grail for the first time.

THREAD. A collection of excellent scarecrows I have met on walks in the countryside.

You will find the all-important caption to each photo in the alt text.

1 month ago 542 156 14 45
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I finally had some time to improve my poster about staging Drosophila embryos in collaboration with @stramerlab.bsky.social and we would like to share this with the community! You can find it here or at a higher resolution on my portfolio: www.behance.net/gallery/2458...
#DrosophilaEmbryogenesis

1 month ago 48 21 2 2
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Friends Davor Solter and Azim Surani receiving the wonderful Paul Ehrlich and Ludwig Darmstaedter Prize for Genomic Imprinting👏 👍 @Frankfurt Germany. With official talks from politicians using words like Education, Knowledge, Democracy 🙏 @maxplanck.de @gurdoninstitute.bsky.social

1 month ago 27 10 0 0

The Cambridge branch of FlyBase will need continuing support! But it's good news that there is restored funding for the US groups of FlyBase.

1 month ago 12 6 1 0
Schedule of the TriRhena Gene Regulation Club 2026 symposium listing times, speakers, and topics on gene regulation and chromatin accessibility, organized by IGBMC Strasbourg, FMI Basel, and MPI-IE Freiburg.

Schedule of the TriRhena Gene Regulation Club 2026 symposium listing times, speakers, and topics on gene regulation and chromatin accessibility, organized by IGBMC Strasbourg, FMI Basel, and MPI-IE Freiburg.

Next week, the Gene Regulation Club has its first stop in 2026. The 1-day symposium brings together researchers from TriRhena 🇫🇷🇨🇭🇩🇪 region including IGBMC, MPI-IE & FMI.

This time at the @igbmc.bsky.social (Strasbourg) with a NewPI talk by @simonelsasser.bsky.social

More: www.ie-freiburg.mpg.de/grc

1 month ago 4 5 0 0

and also the KIT @kit.edu! Congratulation!

1 month ago 4 0 0 0
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Check out this collaboration between Kellie Jurado’s lab and mine. We find that paternal immune activation reprograms the epididymis and, subsequently, small RNAs in sperm, which modulate post-fertilization embryonic gene expression and immunity in offspring in a sex-specific manner.

1 month ago 13 8 0 1
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The amazing colors on this purple harlequin toad [📹 indicator_species]

Original post

1 month ago 1297 239 44 31
Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Flyer for symposium: https://ctrlepiedit.sciencesconf.org/

Very excited to announce the FIRST symposium on epigenome editing! These tools are becoming widely used in mol bio, ag & therapy. It's time to bring leaders together to discuss this rapidly growing and exciting field. And why not in Paris! Please register & share! (1/2) ctrlepiedit.sciencesconf.org

1 month ago 84 58 3 6
Spring Snowflakes in the Austrian Alps.

Spring Snowflakes in the Austrian Alps.

Spring arrived in the Alps!

1 month ago 46 5 0 0