Simple machine learning tools (here, SVM) can achieve high performance when predicting small molecules against user-defined target proteins. Ying's much improved manuscript now online: www.biorxiv.org/content/10.1...
Our new review discussing how machine intelligence can help the discovery of predictive biomarkers: www.nature.com/articles/s41...
Pre-print alert: defining colon fibroblast species by their location and the genes they express, in health and in cancer: www.biorxiv.org/content/10.1...
2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!
Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI
These are not just grants. This is thousands of people who devoted their lives and careers - taking pay cuts, working long hours, living with uncertainty - all for the chance to try to make people's lives a bit better for you and your loved ones. This breaks my heart.
How complete are the current single-cell profiling efforts? Happy to share our updated manuscript now online in www.biorxiv.org/content/10.1...
Now online in Cancer Discovery: Activated T Cells Break Tumor Immunosuppression by Macrophage Re-education - by Rosa Trotta, Silvia Rivis, Shikang Zhao, Massimiliano Mazzone and colleagues doi.org/10.1158/2159...
This is catastrophic for pancreatic cancer patients
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️
ats.talentadore.com/apply/vaitos...
📸 @oonapaavolainen.bsky.social
Always a humbling experience 😀👍
Calling all researchers interested in drug repurposing!🔬💊
A new review on computational drug repurposing resources from the REMEDi4ALL consortium has been published in Nature Reviews Drug Discovery!🎉📄
📖Full review: loom.ly/F7KIRjM
🌐More: loom.ly/d1YRQyM
How to find new uses for existing drugs? Our massive review on computational drug repurposing is now online on Nature Reviews Drug Discovery. Team effort from the REMEDi4ALL consortium. doi.org/10.1038/s415...
https://pathsocjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/path.6405
Spatial transcriptomics study of the human prostate: ANO7 (PrCa risk gene) shows a switch-like on/off expression patterns in adjacent epithelia, which differ in the amount of NK cell infiltration and lipid metabolism among other things. Super interesting and fun collaboration
So excited that our study made the cover of Nature Genetics this month!
Yes! We started thinking tissues as ecological communities consisting of cells and it is fun: www.biorxiv.org/content/10.1...
Collage of immunostaining microscopy pictures of #Drosophila ovarioles.
Today's #microscopy session inspired me to do some art. These ovarioles look like trees, don't you think? If you want to learn what made them this way, stay tuned for our #SingleCell analysis of these - preprint coming soon!
🧬 Are single-cell atlases complete? This was an interesting one to do: www.biorxiv.org/content/10.1... #scRNAseq #single-cell #atlas #cell #biodiversity #biostatistics
AI@HHMI teaser saying "AI@HHMI | Accelerating Innovation in Biology". The backdrop is an artistic rendering of the compute graph of a network architecture for semantic image segmentation that I think looks really cute.
We are looking for exceptional #AIScientist|s to join our #AI@HHMI initiative at #HHMIJanelia. We want to uncover fundamental principles underlying complex biological systems that are inaccessible without new innovations that combine #AI with experimental design.
ai.hhmi.org#join-our-team
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