The team behind my favorite graph - @ourworldindata.org - is hiring a writer.

If you can explain complicated things in ways that change how people think AND you want that skill pointed at the world's largest problems, consider applying: ourworldindata.org/hiring-writ...

How to Build a Strep A Vaccine After decades of scientific and regulatory delays, several Strep A vaccine candidates are entering clinical trials. Without further funding for phase 3 studies, however, many will be hamstrung.

The FDA accidentally froze Strep A vaccine development for 27 years.

@asimovpress.bsky.social explains what happened and where things stand now.

press.asimov.com/articles/strep

This is one of the most important roles I’m hiring for this year - if you’re in doubt, please apply!

Managing Director, Philanthropic Advisory Coefficient Giving is hiring a Managing Director, Philanthropic Advisory to lead our growing partnerships work, build a new advisory practice from the ground up, and help shape our organizational strategy as a member of our leadership team https://coefficientgiving.org/about-us/team/#leadership. We face a historic opportunity to scale philanthropic giving to the highest-impact causes, from global health and biosecurity to AI safety and beyond. We want to build the infrastructure to make that happen, with a goal of eventually directing more than $1 billion annually from donors beyond our founding partner, Good Ventures https://goodventures.org/. Your job is to build the bespoke advisory practice that supports the next generation of major philanthropists, while overseeing and expanding our current funds and partnership offerings. While the advisory function spans our full portfolio, we expect AI safety and biosecurity philanthropy to be a key part of your work. ABOUT COEFFICIENT GIVIN

The application form is here: jobs.ashbyhq.com/coefficient...

We’re not looking for a conventional fundraising background. We want someone with the capability and drive to be a “general manager” of directing new funding to impactful causes (h/t Nan Ransohoff) nanransohoff.substack.com/p/there-sho...

The ideal candidate is:

• Strategically sharp and substantively deep on CG’s cause areas
• An effective executive that can build a strong team
• An excellent external representative of CG’s work to major donors

This person will build a bespoke advisory practice from ~scratch, lead our partnerships team (12 people and growing), and sit on our leadership team.

In the coming years, billions in new philanthropic capital could be unlocked. Whether that money is matched to the highest-impact opportunities is far from guaranteed.

At CG, we’re hiring for a Managing Director, Philanthropic Advisory to make this influx of capital go as well as possible.

I usually end up mostly reading fiction because it's easier and more fun than most nonfiction. But I read "And the Band Played On" recently and loved it. Incredibly info-dense, but extremely well-written and page-turning. Any recs for other great readable nonfiction like this?

Great reporting from @chronphilanthropy.bsky.social on our grantee @cureswithinreach.bsky.social, which runs small trials testing whether existing, approved drugs might work for entirely different diseases.

2025 Letter from the CEO Coefficient Giving directed over $1 billion in 2025, the most in our history. This significant milestone is the result of extraordinary dedication from our funders, staff, and grantees, who share the conviction that effective philanthropy can be a powerful lever for making the world a much better place.

And in case you missed it, more on my thoughts after 15 years as a grantmaker + where we're headed next: coefficientgiving.org/research/20...

I'm grateful to Cari and Dustin for their partnership over the last decade, to our 170+ (and growing!) staff, and to our grantees doing this work on the ground. Here's to the next $5B going faster and further than the previous.

The next few years will look different for us: we're working with a wider range of donors and raising our ambitions for what we can achieve with our giving.

Relative to similarly sized foundations where we've been able to source data, we're also unusual in moving more money and making more grants per staff member.

Since we started, we've formally investigated over 5,000 grants and 200+ cause areas - an unusually large amount even for major foundations.

Some numbers I continue to be proud of:
- Our global health grants have saved over 100k lives
- Our farm animal welfare work has improved conditions for 3B+ animals
- We supported late-stage trials for the R21 malaria vaccine, now being rolled out to millions of kids globally

But what makes me think we punch above our weight is less the dollar amount and more where we put it: problems that are big, tractable, and that almost nobody else is funding.

$5B is a lot of money, but it's still small relative to the problems. As a reference point, annual US charitable giving capital is ~$600B.

Coefficient Giving recently passed $5 billion in total grants directed since we started in 2014. A few things about what that number actually represents 🧵

Turns out "let people build homes" is a pretty intuitive political message!
calmatters.org/housing/202...

bsky.app/profile/vox...

RFP on Effective Careers We are excited to announce a new Request for Proposals (RFP) for effective career organizations, defined as initiatives devoted to providing mentorship, advice, and opportunities to help people pursue highly impactful careers. Through this RFP, we aim to identify and support additional efforts in the effective careers space and streamline the application process for potential […]

Some of our best grants have been in talent, helping people find their way to high-impact careers. We think there's way more room to grow here, so we're launching an open RFP.

If you run an org that helps people have an impact with their career, apply! coefficientgiving.org/funds/effec...

Here’s the PDF again if you want to dig in: coefficientgiving.org/wp-content/...

Expression of Interest Open Philanthropy is now Coefficient Giving. You can read more about this decision and our growing work with multiple philanthropic partners on our new website here https://coefficientgiving.org/research/open-philanthropy-is-now-coefficient-giving/. If you’re interested in working at Coefficient Giving but don't see an open role that matches your skillset, we'd still like to hear from you! This form allows you to indicate that you're open to us contacting you about upcoming roles or opportunistic needs that might fit your skillset. We understand that you may not be available immediately, and that’s okay — expressing your interest now allows us to consider you for future opportunities as they arise. While thoughtful use of LLMs (e.g. ChatGPT, Claude) is not unusual at Coefficient Giving, we ask that you don’t use them to answer the questions on this form. We’ve found that authentic, unassisted answers will give us the clearest sense of your voice, thinking, and fit for roles at Coeff

To do that, we need excellent people across the board. If you’ve ever thought of working with us, now is a really great time, and I encourage you to let us know what you’re excited to work on here: jobs.ashbyhq.com/coefficient...

As we grow, I want to resist the natural pull toward risk aversion and caution so that we can stay agile, make big decisions quickly, and continue to make weird-seeming bets on underappreciated topics.

On the other hand, several brilliant colleagues departed this year: Tom Davidson, Ajeya Cotra, and Joe Carlsmith. All made huge contributions to CG and to the world's thinking on AI, and it's been sad to say goodbye.

We also hired @justsand.bsky.social from @cgdev.org to lead our program on economic growth in LMICs, and Stephanie Hill, who led people operations at @give-directly.bsky.social as they scaled from 250 to 950 staff.

I got to welcome lots of great colleagues in 2025. @mattsclancy.bsky.social brought on a solid chunk of my feed as team members of the Abundance and Growth Fund, including @dylanmatt.bsky.social, @aarmlovi.bsky.social, and more. They have a great blog: abundanceandgrowthblog.substack.com/

Speaking of excellent people: the Coefficient leadership team were all less than 6 months into their roles at the beginning of 2025. We’re now a year into our new incarnation, and I feel incredibly lucky to work with such an outstanding group of people.

Two colleagues who embody this attitude: Lewis Bollard, whose team has improved conditions for 3b+ farm animals since 2015, and Andrew Snyder-Beattie, who aims to reduce biorisk with an unusual and impressive dedication.

We want Coefficient to be a place that attracts people like this.