I am pleased to share our latest pre-print and another collaborative effort with @irinabezsonova.bsky.social. www.biorxiv.org/content/10.6...

New preprint from the lab is now on Biorxiv and a new structure in pdb!
We show that PML protein has an RNA-binding module, we named PIXEL, which modulates human transcriptome. We determine its structure and sequence-specificity. Such fun project!

www.biorxiv.org/content/10.6...

Check out this exciting new report on NEDDylation of DNA polymerase eta. Happy our lab could contribute to this work led by @nicholaswashton.bsky.social and colleagues.

Staff Research Scientist (CEST MRI, imaging molecular binding and metabolism) F. M. Kirby Research Center, US-MD-Baltimore jobs.kennedykrieger.org/baltimore-md... #NMRjobs #NMRchat 🧲

With the band!

Hi James! Are you going to be at the meeting?

Yay!

I’m so excited for a chance to visit Australia and looking forward to #AusUb2025

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 23/31
Prompt FIREFLY
Pdb: 2D1R

Luciferase: firefly enzyme catalyzes a light-producing reaction that makes fireflies glow.

Next: ROWDY
Suggestions?

Yay, love it!

Thanks Karolin!

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 22/31
Prompt BUTTON
Pdb: 1ZXK

Like tiny buttons, cell adhesion proteins such as this Cadherin-8 hold cells together to form tissues.

Next: FIREFLY
Suggestions?

As always, interesting suggestion!

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 21/31
Prompt BLAST
Pdb: 1GVR

An oxidoreductase enzyme PETN from bacterium Enterobacter cloacae can bind and degrade high explosives such as TNT 💥

Next: BUTTON
Suggestions?

Thanks!

Intriguing!

Thanks, and congrats on the beautiful paper.

Congratulations!

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 20/31
Prompt RIVALS
Pdb: 8V27 & 8G6S

Two rival histone modifications on a nucleosome. Ubiquitination of H2BK120 activates genes while H2AK119 represses them.

Next: BLAST
Suggestions?

Nope!

I’ve been traveling to fun places and meeting awesome people at the IPS meeting in Brazil but falling behind on my inktober artwork. Here is the preview for the prompt RIVAL.
Guess what it is!

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 19/31
Prompt ARCTIC
Pdb: 3UYU

Meet ice-binding protein (LeIBP) from Arctic yeast that acts like antifreeze!

Next: RIVALS
Suggestions?

Even more so when you look at the pdb in 3D.

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 18/31
Prompt DEAL
Pdb: 9MKL

A handshaking dimer of a tRNA deacylase strikes a deal to keep translation faithful.

Next: ARCTIC
Suggestions?

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 17/31
Prompt ORNATE
Pdb: 9MME

For the Escher fans!
An ornate molecular cage made entirely of RNA.

Next: DEAL
Suggestions?

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 16/31
Prompt BLUNDER
Pdb: 8G5J

DNA mismatch blunder being fixed by mitochondrial DNA polymerase γ.

Next: ORNATE
Suggestions?

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 15/31
Prompt RAGGED
Pdb: 2W8M

A rugged nuclease D212 from a virus that preys on archaea in the scalding waters of hot springs.

Next: BLUNDER
Suggestions?

Week 2 of inktober is over! Here are my first drafts.

This October I’m drawing 1 molecule a day inspired by proteins in pdb @rcsbpdb.bsky.social

Day 14/31
Prompt TRUNK
Pdb: 1FNY

Lectin. This old tree house is made of a lectin protein found in the bark of a black locust tree, Robinia pseudoacacia.

Next: RAGGED
Suggestions?