Club Cancer Research CLuB’s ambition and focus are on identifying and developing minimally-invasive, cost effective, blood tests to complement or, where possible, replace surgical biopsies for cancer diagnosis and optimal treatment selection. CLuB also uses excised tumours as “avatars” to better understand the specific origin of important components of the liquid biopsy and to test the optimal drug treatment regime for a given patient.

📢Congratulations to CLuB investigator Dr Sharon O'Toole for her award: www.clubcancer.ie/news-events/... #CLuBCancer #STEM igcs.org/2025-dicey-s...

Bicyclo[1.1.1]pentane is a rigid aliphatic hydrocarbon with a three-dimensional (3D), propeller-like shape and a molecular size which makes it a targeted bioisosteric replacement for phenylene and acetylene groups in medicinal chemistry. For the pharmaceutical application of BCP, simple, efficient, and cost-effective synthetic tools are required to enable the exploration of BCP’s potential as a bioisostere across a broad chemical space. The synthesis of BCP mono- and diketones remains a challenging task, limited by both substrate scope and expensive photocatalysts. Here we present a protocol for Friedel-Crafts acylation of (hetero)aromatic hydrocarbons with BCP acyl chlorides; in particular, the first method to access diaromatic BCP 1,3-diketones. Reaction optimization, substrate scope, and reactivity of the products are discussed. 35 mono- and diketones are reported accompanied by 7 examples of post-synthetic modifications. The synthesis of a BCP analogue of fenofibrate is reported.

Check out our new #preprint 📢😀"Bicyclo[1.1.1]pentane Ketones via Friedel-Crafts Acylation" #BCP #isostere @chemrxiv.bsky.social
chemrxiv.org/engage/chemr... great work by Freya and Karolina and coop with #PavelMykhailiuk #EnamineLtd
🇺🇦 supported by @researchireland.ie @ias-tum.bsky.social

Delighted to have taken part in this project that was published today led by Tomas Ryan’s lab @tjryan.bsky.social @tcddublin.bsky.social @tbsi-tcd.bsky.social ….. mice remember cold 🐭📝❄️

Huntington's Disease Research Day May 9 TCD

Looking forward to the
@tcddublin.bsky.social
Huntington's Disease Research Day on May 9th.
#HuntingtonsDisease @evawoods.bsky.social @cpeelo.bsky.social
Registration Link forms.gle/hAjaRjo1Npmj...

👏👏Huge congratulations to Prof. Mathias Senge from School of Chemistry and Prof. James Meaney from School of Medicine and St James's Hospital for securing over € 5 million in funding from @researchireland.bsky.social🎉#TrinityResearch @trinityresearch.bsky.social www.tcd.ie/news_events/...

Vincent Kelly, Professor in Trinity’s School of Biochemistry and Immunology, will direct the ARC Hub for Therapeutics, which will be headquartered in the Trinity Biomedical Sciences Institute.

www.tcd.ie/news_events/...