Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Im thrilled to share that our manuscript is online now at Nature.
www.nature.com/articles/s41...
In this study we find novel cross reactivity between commensal specific T cells and host proteins. This highlights mechanisms that influence commensal-induced autoimmunity.

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis Immune-microbiota interactions are required to maintain host homeostasis. Kim et al. identified that steady-state sensing of IL-10 by interstitial macrophages (IMs) prevents spontaneous lung inflammat...

Excited to share our latest story is out now in Immunity. A great collaboration between the Sano and Kim labs at UIC.

IL-10 sensing by lung interstitial macrophages prevents bacterial dysbiosis-driven pulmonary inflammation and maintains immune homeostasis: Immunity www.cell.com/immunity/ful...