Thank you @lysoluis.bsky.social !! And from a different organelle enthusiast, honored! 🤩

My favorite paper in 2026 so far!! Absolutely stunning 🤩

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

How mitochondria organize our 'second genome' EPFL scientists have discovered that a simple shape change in mitochondria helps cells evenly distribute their mitochondrial DNA, solving a long-standing puzzle.

Mitochondria use a shape-shifting process called "pearling" to evenly distribute their DNA, supporting cellular health and offering new insight into mitochondrial genome organization.

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Pearling drives mitochondrial DNA nucleoid distribution | Science www.science.org/doi/10.1126/...

Wonderful and honoured to write a perspective with @prudentlab.bsky.social @mrc-mbu.bsky.social on such an intriguing and cool observation of beautiful mitochondrial biology! Amazing work on how pearling allows mitochondrial genome organisation by @jclandoni.bsky.social @sulianamanley.bsky.social!

Check out the fantastic perspective by @jellevda.bsky.social & @prudentlab.bsky.social on our #pearling work, out in the same @science.org issue!

www.science.org/doi/10.1126/...

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Easter edition of #Mitochondria in #Health and #Disease!
🐰🐣
biomed.news/bims-mitdis/...

@gavinmcstay.bsky.social @mitoscientist.bsky.social @biomednews.bsky.social @mitoscientists.bsky.social

Perling drives mtDNA nucleoid distribution
www.science.org/doi/10.1126/...

See how PKMito dyes promote mitochondrial research😀
@spirochrome.com

Thanks a lot @bioarm.bsky.social !!

Thank you! Microscopy is beautiful and full of creative opportunities 🔬♥️

For bacteria, they do pearl! Not for genome segregation because they have proteins to do it more accurately (one copy vs 1000s in mitos). But they do however make long tubes and let those pearl for substrate sensing, vesicle generation, and other similar processes 📿 some refs in the discussion

Thank you!! And good questions!
It actually doesn't need ER contact, it can happen spontaneously, but the ER triggers it physiologically. We think of it as the cell's strategy to control an otherwise spontaneous process.

@science.org

The biophysical mechanism of mitochondrial pearling | Molecular Biology of the Cell Mitochondrial networks exhibit remarkable dynamics that are driven in part by fission and fusion events. However, there are other reorganizations of the network that do not involve fission and fusion....

We see that MCU-mediated calcium influx is definitely key. Potassium ionophores can also trigger pearling (www.molbiolcell.org/doi/full/10....) but not sure about a countercurrent!

Could this organelle get any cooler? 🤩 Check out this incredible paper by the Juan and only @jclandoni.bsky.social

The longstanding mystery for how mitochondria segregate and position their DNA has been solved!

Read all about it:
www.science.org/doi/10.1126/...

@jclandoni.bsky.social

Here is Juan and I at the 4th of July parade at MBL physiology

@sulianamanley.bsky.social @lycasworks.bsky.social @jmacuada.bsky.social @wallaceucsf.bsky.social @aaandmoore.bsky.social @hhmijanelia.bsky.social

I hope our unexpected findings inspire more creativity-driven science, and massive thanks to the amazing individuals who made this possible, especially the co-authors tagged below 🧑‍🔬👩‍🔬 and everyone who gave feedback along the way! [6/6]

Pearling provides a unifying mechanism for nucleoid dynamic maintenance: triggered by a local ER-Ca influx which propagates across interconnected mitochondria, modulated by cristae integrity, and facilitates subsequent fission. Defective pearling causes pathological nucleoid aggregation. [5/6]

We found that physiological and reversible pearling acts simultaneously as a nucleoid spacing ruler and disaggregation mechanism, elegantly establishing the fundamental distribution of #mtDNA nucleoids. [4/6]

The answer: Pearling! A frequent and reversible biophysical shape transformation that turns tubular mitochondria into a "beads-on-a-string" morphology, first sketched by Margaret Reed Lewis a century ago and overlooked since. [3/6]

Pearling drives mitochondrial DNA nucleoid distribution The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

#Mitochondrial genomes are packaged into nucleoids, precisely spaced throughout the mitochondrial network to ensure their function, inheritance, and health. How the cell achieves this spacing had remained unknown. www.science.org/doi/10.1126/... [2/6]

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

“Why Did This Evolve? It Didn’t. It Was Already There” - @jclandoni.bsky.social

👉 www.iflscience.com/why-did-this...

A #PhD student's documentation of a senior #postdoc in his natural habitat.

Review title

Review sections graphic

Sub compartments of mitochondria graphic

Mitochondrial.dynamics graphic

🔬 Curious about #mitochondria #imaging but unsure where to begin? Our review might help! 🚀📜🧪

www.annualreviews.org/content/jour...

#Quantitative #Microscopy #SuperResolution #AcademicSky #ScienceSky #CellBiology #mtDNA

Remote work in 🇨🇭 can look beautifully strange 🚂🏔️

Rare diseases are not so rare. Make a difference: www.rarediseaseday.org #RareDiseaseDay

Functional nutrient-genetic profiling reveals biotin and FBXW7 are essential to bypass glutamine addiction Lisci et al. present a unified model revealing how cells escape glutamine addiction, a metabolic vulnerability of several cancers. Combining systematic genetic and nutrient screens, they show that bio...

Our story on #FBXW7 and #biotin in #glutamine_addiction is now peer-reviewed and published in Molecular Cell! Heroic work led by the very first postdoc of the lab @miriamlisci.bsky.social. Have a look!

www.cell.com/molecular-ce...