I will be speaking about this work next week at the Probabilistic Modeling in Genomics conference in Berkeley on Thursday @ 11:30 am. If you’re attending, come and say hi!

We also present a simplified model of QTL discovery, suggesting that caQTL sensitivity more easily captures regulatory variants than eQTLs at constrained genes. Since GWAS hits are enriched at these genes, caQTLs can supplement eQTLs in interpreting the molecular mechanisms of trait heritability.

Excited to finally share my recent preprint with @struangrant.bsky.social!

www.biorxiv.org/content/10.6...

We collected chromatin accessibility QTLs (caQTLs) from 10 different studies and observed that they are less depleted at selectively constrained genes compared to eQTLs.

👇👇👇

I'll be at #ASHG25 this week! Check out my poster Wed 2:30-4:30, at 5071W.

"Bridging the GWAS-eQTL colocalization gap with insights from caQTL analyses" with @struangrant.bsky.social and Laura Almasy

Most p-value explanations that I've come across focus only on the mechanical process of calculation, without telling students why they're doing it or how to interpret the results. So this video is me attempting to motivate the concept of hypothesis testing from first principles.

What is a p-value? #SoME4 YouTube video by Max Dudek

My foray into video creation! This is my entry into #SoME4, an annual exposition of math-explainers. A friendly introduction to hypothesis testing, with minimal math background required.

www.youtube.com/watch?v=qEE0rzytHls

The 2026 Probabilistic Modeling in Genomics (ProbGen) meeting will be held at UC Berkeley, March 25-28, 2026. We have an amazing list of keynote speakers and session chairs:
probgen2026.github.io

Please help spread the news.

Congrats!

Check out @maxdudek.bsky.social paper on fpQTLs!

www.cell.com/ajhg/fulltex...

With @struangrant.bsky.social, @ajhgnews.bsky.social

Full text: authors.elsevier.com/a/1ky1DgeXDywz

Characterization of non-coding variants associated with transcription-factor binding through ATAC-seq-defined footprint QTLs in liver Dudek et al. use chromatin accessibility data in liver from 170 human donors to measure transcription factor binding at genetic variants. They observed 809 variants associated with binding. Given bind...

Our new paper is out today in AJHG! We applied a "footprinting" algorithm to ATAC-seq data from 170 livers to find non-coding variants associated with TF binding. We show that these "footprint QTLs" (#fpQTLs) can fine-map GWAS loci at base-pair resolution.
www.cell.com/ajhg/fulltex...

Populism, Media Revolutions, and Our Terrible Moment YouTube video by vlogbrothers

This is one of those videos that you could work on forever, but suddenly it felt very important to make it, so I finally did: www.youtube.com/watch?v=d8Pn...

Good to see @maxdudek.bsky.social on here now - here’s his recent preprint