Here the authors highlight potential therapeutic benefits of 4 weeks of β2-AR stimulation for improving muscle-specific glucose uptake in individuals with or at risk for developing diabetes #T2D www.nature.com/articles/s41...

Dulaglutide and neurodegeneration biomarkers: REWIND post hoc analysis INTRODUCTION This post hoc analysis of the Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial examined associations between dulaglutide, Alzheimer's disease and rela...

Revisiting changes in cognitive function and biomarkers of Alzheimer’s disease in REWIND alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

The role of fructose not only as a caloric source, but also as a regulator of metabolic health and disease www.nature.com/articles/s42... @natmetabolism.nature.com

The weight-loss-independent hepatoprotective benefits of semaglutide are orchestrated by intrahepatic sinusoidal endothelial GLP-1 receptors GLP-1 medicines are used to treat people with type 2 diabetes, obesity, and metabolic dysfunction-associated steatohepatitis (MASH). Here, Gonzalez-Rellan et al. demonstrate that semaglutide activates...

How do GLP-1 meds improve liver health through #weightloss independent mechanisms? Here Dr. Gonzalez Rellan & colleagues identify Liver Sinusoidal Endothelial Cells as direct targets of semaglutide, linking LSECs to reduction of #inflammation #Fibrosis #MASH www.cell.com/cell-metabol...

Although #weightloss is highly beneficial to reduce fat and inflammation in the liver, posthoc analysis of the ESSENCE trial reveals substantial weight loss-independent benefits of semaglutide #MASH How does this happen?

Updates on paediatric MASLD: insights from an endocrine lens - Diabetologia Paediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease in children and adolescents worldwide and is increasing alongside rising rates...

Pediatric #MASLD @diabetologiajnl.bsky.social
link.springer.com/article/10.1...

Neuronal lipid droplets play a conserved and sex-biased role in maintaining whole-body energy homeostasis - Nature Metabolism In vivo regulation of neuronal lipid droplet formation mediates whole-body energy homeostasis in a sex-specific manner in Drosophila and mice.

Neuronal lipid droplet-derived lipids support neuron function by providing fatty acids and phospholipids to sustain mitochondrial and endoplasmic reticulum function and homeostasis. www.nature.com/articles/s42...

Genetic screens provide mechanistic insights into the regulation of proinsulin/insulin homeostasis www.nature.com/articles/s41...

Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting - Nature Genetics Multi-ancestry GWAS meta-analysis identifies risk loci for severe nausea and vomiting of pregnancy. Downstream analyses explore maternal and fetal contributions of these loci and their temporal effect...

Expanding the #genetics of #pregnancy associated nausea and vomiting www.nature.com/articles/s41...

A new review on GIP from the experts. While the narrative clearly highlights GIPR agonism suppresses food intake, the Figure implies GIP increases food intake diabetesjournals.org/care/article...

Towards actionable ascertainment of #diabetes risk in cluster subtypes with #weightloss diabetesjournals.org/diabetes/art...

Here the authors propose that TOX3 in POMC-lineage cells are essential for maintaining energy homeostasis in mice, driving thermogenesis, thereby revealing therapeutic opportunities for metabolic disorders #obesity www.nature.com/articles/s41...

The plant hormone, 6-benzylaminopurine, ameliorates obesity in male and female mice while on a high-fat diet Obesity is a global health crisis. Currently available treatments, while effective, show several undesirable side effects that hinder their long-term …

New from Professor Belsham @denisebelsham.bsky.social
The naturally ocurring phytohormone BAP causes #weightloss in obese mice via sex-specific mechanisms www.sciencedirect.com/science/arti...

Happy birthday to Professor Emeritus Bernie Zinman, newly elected member of the @CdnMedHallFame @uoftmedicine @SinaiHealth www.cdnmedhall.ca/bernard-zinm... #diabetes @DiabetesCanada

As the therapeutic benefits of GLP-1 medicines expand, the interest in the weight loss independent contributions continues to unfold linkinghub.elsevier.com/retrieve/pii...

Potential cerebrovascular benefits of GLP-1 medicines in real world data for patients with moyamoya disease thejns.org/view/journal...

Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner - Translational Psychiatry Translational Psychiatry - Not only gut feelings: pancreatic hormone, amylin, controls emotionality and sociability, in a sex divergent manner

In rats, amylin modulates emotional and social behaviors in a divergent sex-dependent manner www.nature.com/articles/s41...

A new chapter from the Scherer lab on adipose tissue communication via extracellular vesicles www.nature.com/articles/s41...

How to train your rodent: Recommendations for the preclinical study of exercise-induced benefits in metabolic research Regular physical activity is fundamental in promoting health; however, uncovering the molecular adaptations remains challenging in humans. Rodent models have been indispensable for unveiling biologica...

Down at the gym, new recommendations for harmonizing preclinical #exercise physiology www.cell.com/cell-metabol...

Dose–response analysis of tirzepatide and acute pancreatitis: An international systematic review and quantitative meta-analysis of randomised trials Tirzepatide, a dual GIP/GLP-1 receptor agonist for type 2 diabetes and obesity, carries a theoretical risk of pancreatitis. Whether risk varies by dos…

GLP-1 medicines and #pancreatitis After 21 years, lots of smoke, no fire. Here a look at Tirzepatide www.sciencedirect.com/science/arti... www.google.com/imgres?q=pan...

Here the authors propose repurposing readily accessible DPP-4 inhibitors to enhance anti-tumor CD8+ T cell responses #cancer www.biorxiv.org/content/10.6...

Associations in humans suggest that Hyperglucagonemia in the face of higher hepatic lipid content in early #T2D is not due to differences in insulin sensitivity or glucagonotropic metabolites but could suggest hepatic glucagon resistance diabetesjournals.org/care/article...

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells - Nature Metabolism This study demonstrates that overexpression of irisin, an exercise-induced myokine, ameliorates obesity and insulin resistance in high-fat-diet-fed mice by increasing local IL-33 production and preser...

Novel irisin-driven cell–cell and inter-tissue immune interactions improve #obesity and glucose intolerance, and increase energy expenditure, with no reduced food intake and muscle loss in obese mice. www.nature.com/articles/s42...

Increasing options for patients with a choice of new oral GLP-1 medicines is a welcome development. The competitive messaging is well underway for oral semaglutide vs. Orforglipron #weightloss #tolerability www.novonordisk.com/news-and-med...

Studies of mouse adipose tissue biology continue to underpin the enthusiastic pursuit of new targets to enhance thermogenesis in humans www.nature.com/articles/s41...

GLP-1 Receptor Agonists and Noncardiometabolic Outcomes This meta-analysis evaluates the reported outcomes of glucagon-like peptide-1 (GLP-1) receptor agonists beyond glycemic control, weight management, and cardiorenal protection and assesses the credibil...

The epidemiology of GLP-1 medicines-suggestive protective associations with reduced rates of respiratory diseases and serious infections require further confirmation jamanetwork.com/journals/jam...

Revitalizing p-GSK-3β via cysteine sulfenylation promotes hepatic insulin resistance by differentially regulating glycogenesis and gluconeogenesis - Nature Metabolism ROS-mediated sulfenylation or ‘oxidative activation’ of p-GSK-3β can terminate glycogenesis and initiate gluconeogenesis by modulating Gys2 and FoxO1, leading to hepatic insulin resistance.

Preclinical studies define potential strategies against hepatic insulin resistance by targeting sulfenylated or ‘oxidatively activated’ p-GSK-3β. www.nature.com/articles/s42...

Semaglutide on liver fibrosis and heart outcomes in patients at high risk of liver fibrosis: a prespecified analysis of the SELECT randomized trial - Nature Medicine A prespecified analysis from the SELECT trial showed that semaglutide reduces major adverse cardiovascular events by 20% compared with placebo, particularly in patients at high risk of fibrosis, as in...

Prespecified analyses reveal semaglutide reduced MACE in patients at risk for substantial liver fibrosis, in the overall SELECT population www.nature.com/articles/s41...

The 2026 Canada GairdnerAwards Laureates from Cryo-EM to amyloid aggregation,systems proteomics, cholera control, bacterial immunity, BP control after spinalinjury #Science www.newswire.ca/news-release...

A continuous intravenous LEAP2 infusion for 5 hrs reduces glycemia and food intake in men with #obesity diabetesjournals.org/diabetes/art...