Had a wonderful time at our department Christmas party! @ermakov-mikhail.bsky.social @tylerjost.bsky.social @ajitjohnson.com

🚀✨Exciting update for #scimap users!🚀

We've supercharged #visualgating with:

🖼️ Memory optimization for huge images
🔗 Seamless Napari component linking
⏱️ Fewer clicks = faster, smoother gating

Get ready for a speed boost to your workflows! ⚡🙌
scimap.xyz/Functions/pl...

#imaging #spatialbiology 🧪

They show that CTCL tumor cells are spatially associated with B cells, forming tertiary lymphoid structure-like aggregates and validated the enrichment of B cells and its association with disease progression across three independent patient cohorts.

Atlas of Cutaneous T Cell Lymphoma Unveils Malignant TH2 Cells Sustained by a B Cell-Enriched Tumor Microenvironment 🧪

idp.nature.com/authorize?re...

Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue - Scientific Reports Scientific Reports - Optimizing immunofluorescence with high-dynamic-range imaging to enhance PD-L1 expression evaluation for 3D pathology assessment from NSCLC tumor tissue

The HDR approach dramatically improves accuracy in PD-L1 evaluation and enables 3D spatial analysis of tumor tissues—a step towards more precise pathology! www.nature.com/articles/s41...

PDL1 is generally very weak and heterogeneous, making it difficult to image (given its importance clinically). Huang et al. optimized a high-dynamic-range (HDR) imaging method for immunofluorescence to assess PD-L1 expression. 🧪

Would love to join as well.

Spatiotemporal modeling of molecular holograms Spateo is a comprehensive framework for 3D reconstruction and characterization of spatial gradients and cellular interactions at whole-organ and embryo levels, using spatial transcriptomics. Important...

A fascinating tool linking embryonic growth to molecular signals. www.cell.com/cell/fulltex...

Great work by Qiu et al.—Spateo builds detailed 3D models of mouse embryos, capturing spatial dynamics and cell interactions. They use morphometric vector fields to reveal the molecular drivers of asymmetric heart development. 🧪

Let’s create a community for #spatialbiology - Let’s add to this list.

go.bsky.app/AE8csH9