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Posts by Nate Jacobs

Congratulations!

2 weeks ago 1 0 0 0

My kingdom for a billing code to track how many hours iManage/Lenovo/Windows issues keep me from billing or doing real non-billable work.

1 month ago 2 1 1 0

Who among us has not missed the, er, thematic rock sculpture by the real door and walked right into this dentist office-like entryway 😑

1 month ago 0 0 0 0
Hallgrimskirkja, a church in Reykjavik, Iceland resembling a normal distribution with constant vertical offset.

Hallgrimskirkja, a church in Reykjavik, Iceland resembling a normal distribution with constant vertical offset.

Tfw your standard deviation is much less than 1

1 month ago 0 0 0 0

“One would expect that, after several years of law school, and more years of practice, those attorneys believe they bring some level of value to their clients beyond that of a machine.”

BRB searching PatBase for methods of melting into a floor.

2 months ago 2 0 0 0
Incredible art of gritty playing fiddle on the roof of a west Philadelphia row home. In Yiddish it says Fidler Oyfn Fakh פֿידלער אױפֿן דאַך)

Incredible art of gritty playing fiddle on the roof of a west Philadelphia row home. In Yiddish it says Fidler Oyfn Fakh פֿידלער אױפֿן דאַך)

We put on an all-Yiddish community production of fiddler on the roof in Philadelphia and cast member and local artist Sofie Rose Seymour created the most amazing show poster that ever was

2 months ago 5742 1647 134 161
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Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

5 months ago 437 199 11 18

Because a specification may be fixed in time, but if the regular updates to seasonal influenza vaccines evoke one fictional character, it's the Red Queen ("Now, here, you see, it takes all the running you can do, to keep in the same place").

5 months ago 0 0 0 0
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Namely, how claim construction, written description, and enablement might intersect with controversy in defining species or other taxa, reclassifications and emergence of new organisms over a 20-year term, and the depth of conservation of relevant biology.

5 months ago 1 0 1 0

With the examples of bacteria and influenza viruses, the article explores the challenges that evolution (of formal names, knowledge of biodiversity, and organisms themselves) can pose for organism-centered patents, and options for addressing them through taxonomy and phylogenetics.

5 months ago 2 0 1 0

Alas, the actual paper focuses more on viruses and bacteria than Pop-Tarts or filled pasta, but I'm still excited to see it published! www.doi.org/10.1093/jlb/...

5 months ago 1 0 1 0
Jinx the black leopard at Florida Big Cat rescue absolutely tearing into a pumpkin.  You can read more about Jinx (and his rescue story) here:
https://bigcatrescue.org/jinx/

Jinx the black leopard at Florida Big Cat rescue absolutely tearing into a pumpkin. You can read more about Jinx (and his rescue story) here: https://bigcatrescue.org/jinx/

The news in the world is awful, but it's almost Halloween, so let's talk about pumpkin enrichment for big cats.

This is Jinx the black leopard (Big Cat Rescue, Florida) enjoying shredding a pumpkin.

2 years ago 2549 950 35 100
Hand-drawn figure of a simple printing press.

Hand-drawn figure of a simple printing press.

BACKGROUND OF THE INVENTION
I am a born again Christian. The Bible says that there will be a certain event known as the rapture, when born again Christians will be taken to heaven as Christ returns to take them away. There will then be a time of peril upon the earth known commonly as the tribulation period. During this time, the AntiChrist will rule, and claim to be the Christ. You will not be able to buy or sell without the number of the beast which is 666. The gospel will be greatly hindered. Anyone giving out the gospel will be beheaded, and those who trust Christ as their Savior will not be able to buy tracts or have them printed in any way. There will no way to give out the gospel anonymously, and yet many, in times of peril, will be seeking the Lord.

BACKGROUND OF THE INVENTION I am a born again Christian. The Bible says that there will be a certain event known as the rapture, when born again Christians will be taken to heaven as Christ returns to take them away. There will then be a time of peril upon the earth known commonly as the tribulation period. During this time, the AntiChrist will rule, and claim to be the Christ. You will not be able to buy or sell without the number of the beast which is 666. The gospel will be greatly hindered. Anyone giving out the gospel will be beheaded, and those who trust Christ as their Savior will not be able to buy tracts or have them printed in any way. There will no way to give out the gospel anonymously, and yet many, in times of peril, will be seeking the Lord.

A homebuilt printing press for publishing after the rapture without drawing the attention of the Antichrist.
Patent Application Publication US 2012/0279405

6 months ago 8 5 0 0
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Near real-time data on the human neutralizing antibody landscape to influenza virus to inform vaccine-strain selection in September 2025 The hemagglutinin of human influenza virus evolves rapidly to erode neutralizing antibody immunity. Twice per year, new vaccine strains are selected with the goal of providing maximum protection again...

In new study led by @ckikawa.bsky.social, we provide near real-time data on human neutralizing antibody landscape to influenza by measuring ~26,000 titers to >100 recent viral strains

Data can inform vaccine selection & evolutionary/epidemiological modeling
www.biorxiv.org/content/10.1...

7 months ago 60 35 1 1

Watching ER and wondering if my firm will ever expand to Chicago.

7 months ago 1 0 0 0
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While riding the B or Q trains between Dekalb Ave station and the Manhattan Bridge, you may catch a glimpse of "Masstransiscope," a public art installation by Bill Brand. It was added to the #NYCsubway system in 1980.

8 months ago 1408 287 16 40
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Q Train Expansion Into Harlem Gets a Green Light, Thanks in Part to Congestion Pricing “Send our friends in Washington a message — it is working,” Gov. Hochul said of the vehicle tolls.

“Send our friends in Washington a message — it is working,” Gov. Hochul said of the vehicle tolls.

8 months ago 102 20 1 3
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A defined microbial community reproduces attributes of fine flavour chocolate fermentation - Nature Microbiology An in-depth microbiological and metagenomic analysis of Colombian farm and fermentation facilities resulted in the design of a defined microbial community that can reproduce the flavour of fine chocol...

This is the science I want funded (alongside curing cancer etc)

A defined microbial community reproduces attributes of fine flavour chocolate fermentation

www.nature.com/articles/s41...

8 months ago 38 9 0 0
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Experimental evolution in an era of molecular manipulation Nature Reviews Genetics, Published online: 21 July 2025; doi:10.1038/s41576-025-00867-6In this Review, Ascensao and Desai discuss how methodological advances in genotype and phenotype manipulation are transforming experimental evolution approaches and providing new insights into the underlying genetics and forces that shape phenotypic evolution.

ICYMI: New online! Experimental evolution in an era of molecular manipulation

8 months ago 13 9 0 0
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a cartoon of a woman wearing a pink hat Alt: Louise Belcher staring with one eye twitching
8 months ago 2 0 0 0

the singular message of this ad is "zohran loves new york city" and it is incredibly effective

9 months ago 20412 2637 366 125
The meme format of “Patrick Star from the episode Band Geeks” asking, “Is Civil Procedure with Richard Freer fun or a distraction?”

The meme format of “Patrick Star from the episode Band Geeks” asking, “Is Civil Procedure with Richard Freer fun or a distraction?”

But also, finally getting around to Black Mirror S7 and reading Code Name: Pale Horse.

9 months ago 1 0 0 0
A chef making a torte, the thin dense cake, not a tort, the cause of action.

A chef making a torte, the thin dense cake, not a tort, the cause of action.

Tortefeasor, you say?

10 months ago 1 0 0 0
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Evolution of the Italian pasta ripiena: the first steps toward a scientific classification - Discover Food In this study, phylogenetic and biogeographic methods are used to investigate the evolutionary relationships between various types of Italian pasta ripiena (filled pasta) and related representatives f...

As an introdcution to the phylogeny of filled pasta paper: link.springer.com/article/10.1...

11 months ago 2 0 0 1
A slide captioned “Ravioli? Or Tortellini?” And showing Pop-Tart mascots.

A slide captioned “Ravioli? Or Tortellini?” And showing Pop-Tart mascots.

My “Taxonomy and Phylogenetics for Patent Attorneys” presentation is coming along nicely.

11 months ago 3 0 1 1
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Wore my pinkest shirt and greenest pants today to channel this Nicole Kidman energy on my way out of my last ever law school final tonight.

11 months ago 4 0 0 0

My Pumpkins? Smashing.

11 months ago 2 0 0 0
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10/10. No Notes

reason.com/volokh/2025/...

11 months ago 486 78 42 43
Nate sits at what appears to be a poker table with five copies of himself, owing to the mirrors bordering a 1/6 wedge of the table. Chicago Museum of Illusions.

Nate sits at what appears to be a poker table with five copies of himself, owing to the mirrors bordering a 1/6 wedge of the table. Chicago Museum of Illusions.

Playing a zero-sum game of poker in the presence of multiple mirrors may not have been the wisest decision.

11 months ago 3 0 0 0