5 months ago
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Posts by Steven Shaw
Exciting PhD opportunity! Uncover the molecular mechanism of the MADS bacterial immune system and its synergy with CRISPR-Cas. Based in the Szczelkun lab in Bristol with strong collaboration with the Blower lab at NEB and opportunities to work with other amazing research groups! Link below:
5 months ago
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This autonomous system ensures destruction of non-self DNA without harming self DNA—an elegant solution to phage infection and horizontal gene transfer threats.
6 months ago
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New preprint!
Using single-molecule and kinetic assays combined with nanopore, myself, @alex-hg.bsky.social, @oscart32.bsky.social & co showed that the SauUSI restriction enzyme from S. aureus recognizes methylated DNA and initiates a motor-driven shredding process.
www.biorxiv.org/cgi/content/...
6 months ago
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Happy that the final version of our Lamassu work @yli18smc.bsky.social is now out:
www.nature.com/articles/s41...
Thanks again to our awesome collaborators @mblokesch.bsky.social and David and co and Mark Szczelkun and @steven-shaw.bsky.social and the DCI Lausanne @fbm-unil.bsky.social
6 months ago
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Alt : Structure of the apo Lamassu protein complex. Schematic model of the active LmuA tetramer nuclease (top right). Lamassu icon (top left).
Glad to share the work of @yli18smc.bsky.social and co on Lamassu, a bacterial defense system related to Rad50/Mre11 (RM). While RM carefully trims DNA ends for repair, Lamassu chops up the host chromosome. Our study reveals how it is regulated to minimize damage, activating only during infection.
1 year ago
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I've been learning Welsh but I'm glad I'm only working with E coli
1 year ago
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I got one of a woman in office clothes pitching Christianity to me for some reason
1 year ago
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