MRE11 proximal polyadenylation site-mediated looping impacts transcription and genomic stability Alternative polyadenylation (APA) generates transcript isoforms with variable 3′ untranslated regions (UTR) lengths, yet its role in DNA damage respon…

Out today in @cp-molcell.bsky.social!

We show that proximal polyadenylation site (pPAS) within MRE11 sustains its transcription through promoter–PAS chromatin looping.

Congratulations to first author Kaimeng Huang, all co-authors and collaborators.

www.sciencedirect.com/science/arti...

Nature Communications banner with title of latest paper from the Yates, Oliver, and Rass groups at the Genome Damage and Stability Centre, University of Sussex: "Break-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32".

An in-press version of our latest paper in @natcomms.nature.com on phospho-activated protein-protein interactions with ssDNA-binding protein RPA during BIR. If your favorite pathway involves RPA, this may be for you! Thanks to the lab, collaborators & @ukri.org!
www.nature.com/articles/s41...

Replicative gaps in DNA damage tolerance, genome instability, and cancer therapy Replicative single-stranded DNA gaps arise when DNA synthesis proceeds past lesions or difficult-to-replicate regions. This review delineates the pathways that generate, stabilize, and process these i...

Excited to share our new review in Molecular Cell on replicative single-stranded DNA gaps and their role in genome instability and cancer therapy.

#DNARepair #ReplicationStress #GenomeStability #CancerResearch #MolecularBiology #PARPinhibitors​​​​​​​​​​​​​​​​

www.cell.com/molecular-ce...

Happy holiday, everyone! 2026 Social DNAing Schedule is now online. Here is a sneak peek. Check it out and sign up at www.cancer.columbia.edu/research/pro...

Congratulations Kavi!

Great to see this team effort out, in which we find a new player in genome stability and a neurodevelopmental disease caused by its loss. Fantastic collaboration with @drjhujh.bsky.social and @profstewartlab.bsky.social alongside @sorenhough.bsky.social and friends in @spjacksongroup.bsky.social.

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels Nature Communications - Replication fork plasticity upon genotoxic stress is modulated by nuclear architectural components by elusive mechanisms. Here the authors implicate Lamin A/C – best...

Thrilled to share our latest work - now available in full in Nature Communications - led in my lab by @vcherdy.bsky.social, with key collaborative contributions from @nitikataneja.bsky.social .

rdcu.be/eVrxX

Proteome-wide in silico screening for human protein-protein interactions Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments Homologous recombination (HR) deficiency upon Breast Cancer Gene 2 (BRCA2) loss arises from defects in the formation of RAD51 nucleoprotein filaments. We demonstrate that loss of the anti-recombinase ...

Want to know how homologous recombination defects are caused upon loss of BRCA2? Check out our recent efforts in uncovering this phenomenon just out in Science!
www.science.org/doi/10.1126/...

Here is a graphic that illustrates some adjectives that our department members say reflect the culture of the department. It is a great place to do research and train.

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicine—Basic Sciences

Less than two weeks left to apply for our TWO tenure track assistant professor positions in Department of Biochemistry at Vanderbilt University School of Medicine. Basic Sciences

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Vanderbilt research looks to smooth out bumps in medicinal chemistry processes Vanderbilt researchers probe the mysteries of an enzyme that could be used as a tool in basic research and medicinal chemistry.

🧪 Vanderbilt researchers are on a mission to “smooth out the bumps” in medicinal chemistry. Their new work addresses key inefficiencies that slow discovery and could accelerate the path from lab to clinic.

Learn more 👉 medschool.vanderbilt.edu/basic-scienc...

Does anyone have another source besides BD for the B44 anti-brdu antibody or one that reacts with Idu and limited with Cldu. It’s badly back ordered.

Image of Toronto

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.

www.nature.com/naturecareer...

Please repost!

Postdoctoral Training Programs Funded by the National Cancer Institute (T32CA186895), the program at City of Hope provides exceptionally motivated, recent (2 years or less) postdoctoral fellows with scientific knowledge, researc

We have openings for a postdoctoral training program on DNA Damage and Oncogenic Signaling. Our past trainees have been very successful. Apply by Aug 31 for full consideration. See link for details. www.imgs-coh.edu/postdoctoral...

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicine—Basic Sciences

Advertisements for 2 tenure-track assistant professor positions at Vanderbilt School of Medicine Basic Sciences:
www.nature.com/naturecareer...
www.nature.com/naturecareer...

The Department of Biochemistry at Vanderbilt University (medschool.vanderbilt.edu/biochemistry/) is searching for TWO new Assistant Professors this year. Apply by October 15! apply.interfolio.com/171767

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells HMCES binding to nascent DNA blocks replication and kills homologous recombination–deficient cancer cells.

Thrilled to share our latest work. Great collab with Costanzo, Masson, Freire and Reyes' labs. Congrats to María José and coauthors

HMCES corrupts replication fork stability during base excision repair in homologous recombination–deficient cells | Science Advances www.science.org/doi/10.1126/...

Congratulations and thanks for this nice resource for the community!

Contributing factors to the oxidation-induced mutational landscape in human cells - Nature Communications 8-oxoG is a common single-base DNA lesion caused by oxidative stress. Here, authors characterize the mutational signature of potassium bromate (KBrO3) exposure, the chromatin structural determinants o...

Very proud of this. It’s both the end and beginning of something new for me. My last paper in @dkcortez.bsky.social lab and my first co-corresponding author. Also truly a great supergroup including @freudlab.bsky.social @tmweaver.bsky.social and Roberts lab

www.nature.com/articles/s41...