Currently, the framework is heavily oriented toward antibacterial resistance, leaving antifungal resistance (AFR) dangerously neglected.

Faculty member, Dr. David Boulware, is among the experts advocating for the immediate integration of AFR into these global One Health commitments. #IDSky

It’s been an incredible week for our team in Munich at #ESCMIDGlobal2026! 🇩🇪
We’ve had the opportunity to present our latest research, dive into deep discussions on global health, and reconnect with colleagues from across the field. #IDSky

Happy #FollowFriday! 🧪 If your "Infectious Disease" starter pack is looking a little thin, give us a follow. #IDSky #MedSky

Assessing Statistical Methods for Estimating the Cerebrospinal Fluid Early Fungicidal Activity as an Endpoint for Cryptococcal Meningitis Clinical Trials: A Systematic Review and Simulation Study AbstractBackground. Cryptococcal meningitis is a life-threatening infection of the central nervous system. Early fungicidal activity (EFA), which measures

📊 New work from @drboulware.bsky.social looks at Early Fungicidal Activity (EFA) in Cryptococcal meningitis.

The 2-step approach is preferred for EFA, particularly when early culture sterility is common. Linear mixed models can bias estimates toward the null. #IDSky #MedSky

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The global landscape of liver cancer is undergoing a major transition. 🦠➡️🍔

• Incidence remains highest in East Asia & Africa.
• Etiology is shifting from predominantly infection-related to metabolic & alcohol-associated.
• Rural-urban disparities are widening the gap in outcomes. #MedSky

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#UMNProud

Lumbar Puncture Frequency and Patient Survival Among Persons Hospitalized with Cryptococcal Meningitis in the United States Abstract. Elevated intracranial pressure contributes to high mortality in cryptococcal meningitis. We evaluated the association between therapeutic lumbar

🚨A new study by incoming fellow Dr. Okuno, mentored by faculty Dr. Boulware and Dr. Bahr, evaluates the association between therapeutic LPs and survival in patients with Cryptococcal Meningitis.

The Findings: repeat LPs are a life-saving intervention across diverse patient populations. #IDSky

State of the Art - CMV: Dr. Mark Schleiss @umn-idim.bsky.social presents 'Newborn Screening for Cytomegalovirus (cCMV) Infection Universal, Targeted, Expanded-Targeted or None-of-the-Above?' with how states are approaching screening. #stjudepids2026

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The Clinical Impact of Antibiotic Allergy Labels on One‐Year Outcomes of Solid Organ Transplant Recipients Antibiotic allergy labels (AALs) are common and often incorrect. They have many potential impacts, including the use of broader-spectrum antibiotics and suboptimal treatment of infections. The impact....

New research from our faculty: antibiotic allergy labels in transplant patients are linked to C. diff infections, more antibiotic use & longer hospital stays, and they may be preventable. 🔬 #IDSky #MedSky

Results: ✅ Inpatient initiation is non-inferior, safe and feasible. ✅ Higher completion: 76% completion in the inpatient group vs. 66% in the outpatient group. ✅ Safety: Adverse events were similar across both groups, though grade 4 anemia was actually less frequent in the inpatient group.

Inpatient initiation of tuberculosis preventive therapy with 1 month of isoniazid and rifapentine for adults with advanced HIV disease and cryptococcal meningitis (IMPROVE): a non-inferiority, randomi... 1HP initiation before hospital discharge was non-inferior to outpatient initiation among adults with AHD and cryptococcosis. These data suggest that following exclusion of active tuberculosis disease,...

Can we improve TB preventive therapy (TPT) for those with advanced HIV? 🏥

A new phase-3 trial from @drboulware.bsky.social and colleagues evaluated two strategies for the 1-month 1HP (rifapentine + isoniazid) regimen in patients with cryptococcal meningitis. #IDSky

Immediate or high-dose antituberculosis therapy for HIV-related sepsis in Tanzania and Uganda (ATLAS): a phase 3, open-label, randomised, controlled, 2 × 2 factorial, superiority trial Among all participants with HIV-related sepsis, 28-day mortality was not significantly reduced with immediate or high-dose antituberculosis therapy. In the subgroup with later confirmed tuberculosis, ...

ATLAS trial by faculty Dr. David Boulware and colleagues, studied TB treatment timing in people with HIV & sepsis in East Africa. Overall mortality unchanged, but early standard-dose TB therapy saved lives in confirmed TB cases. #IDSky #MedSky

Faculty research spotlight: Dr. Rajasingham and colleagues studied point-of-care CD4 testing for advanced HIV in Uganda. Visitect CD4 enabled faster ART initiation with similar 24-week survival and retention-in-care at comparable cost. #IDSky

Faculty highlight: Dr. Dimitri Drekonja and colleagues conducted a study showing AI can streamline infection surveillance after cardiac device procedures—reducing chart review time from ~25 to 5–7 minutes, with excellent accuracy and needed human oversight. #IDSky #AI

Headache as a predictor of cryptococcal meningitis in ambulatory patients with symptomatic HIV-associated cryptococcal antigenemia AbstractBackground. People with HIV-associated cryptococcal antigenemia are at high risk for meningitis and death. In resource-limited settings, lumbar pun

New faculty research in @ofidjournal.bsky.social shows that headache plus high plasma CrAg titer is the strongest predictor of cryptococcal meningitis in people with HIV. When titers are unavailable, combining neurologic symptoms improves triage decisions. #IDSky #MedSky

P-206. Change in Cryptococcal Antigen Titer Over Time in Uganda AbstractBackground. Cryptococcal meningitis causes an estimated 19% of AIDS-related deaths globally and is the leading cause of meningitis in adults with H

@drboulware.bsky.social and team tracked plasma cryptococcal antigen titers over time. Median titers in advanced HIV showed a modest, non-significant upward trend, while the proportion on ART declined.

P-1130. Promoting De-Implementation of Inappropriate Antimicrobial Use Following Cardiac Device Procedures AbstractBackground. Despite a strong evidence base and clinical guidelines specifcally recommending against prolonged post-procedural antimicrobial use, st

Dr. @dimitridrekonja.bsky.social and colleagues examined inappropriate antimicrobial use after cardiac device procedures.

P-90. Microbiology of Spinal Fusion Infections: An Analysis of the National Healthcare Safety Network Database AbstractBackground. Understanding the current microbial causes of surgical site infections (SSIs) following spinal fusion surgeries is essential for guidin

Using cases reported to the National Healthcare Safety Network, Dr. Tai and team analyzed more than 5,000 spinal fusion surgical site infections from 2021–2022 to better understand the role of gram-negative organisms.

University of Minnesota Infectious Diseases researchers presented multiple abstracts at #IDWeek2025, spanning antimicrobial stewardship, global health, and orthopedic infections. Proud of our faculty and trainees. #IDSky

Induction Regimens and Kidney Re‐Transplant Outcomes after BK Nephropathy–Related Graft Loss: A U.S. Cohort Study This study investigated the association between induction type and long-term outcomes in kidney retransplant recipients who experienced graft loss due to BK virus–associated nephropathy (BKVAN). Usin...

New work from Dr. Fontana and colleagues examines induction immunosuppression after BK virus–associated nephropathy–related graft loss. Depletional vs nondepletional induction showed no difference in 10-year graft or patient survival. 🧬🩺 #IDSky
onlinelibrary.wiley.com/doi/10.1111/...

Photo credit to @idsainfo.bsky.social

A late reflection on @idweek.bsky.social , but a memorable start to the meeting. The opening plenary with Drs. Michael Osterholm and Ruth Lynfield set the tone on preparedness, public trust, and why public health partnerships matter. #IDSky

Prolonged antibiotic therapy for spinal implant infection may not improve outcomes ATLANTA — Results presented at IDWeek showed prolonged antibiotic therapy beyond 12 weeks may not improve outcomes for early postoperative spinal implant infections.“Shorter, standardized ...

Prolonged antibiotics may not improve outcomes in early spinal implant infections. At IDWeek, SPIRIT researchers showed no benefit to therapy >12 weeks when optimal surgical source control is achieved. #IDSky

Trial of High-Dose Oral Rifampin in Adults with Tuberculous Meningitis | NEJM Tuberculous meningitis is often lethal, and many survivors have disabilities despite antimicrobial treatment and adjunctive glucocorticoid therapy. Standard-dose rifampin has limited central nervou...

High-dose rifampin did not improve survival in adult tuberculous meningitis. In a trial across 3 countries, 6-month mortality was similar to standard dosing, with more liver injury at higher doses. Important evidence for TB care from @natebahrid.bsky.social @drboulware.bsky.social . #IDSky

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