Merci Ted!!!

14/ @jorsmo.bsky.social @tuckerdrob.bsky.social, Irwin Waldman, @abepalmer.bsky.social, Peter Barr, Sandra Sanchez-Roige, @richardlinner.bsky.social, @drdanielledick.bsky.social, @kph3k.bsky.social, and @wakeworksleep.bsky.social!

13/ @josephdeak.bsky.social, Jean Gonzalez, Mariela Jennings, @ecjohnson.bsky.social, Tanya N. Phung, @mjschipper.bsky.social, Ronald de Vlaming, Kai Yuan, Hang Zhou, Emily Balcke, Sarah Brislin, #COGA, Javier de la Fuente, @mikegandal.bsky.social, Tian Ge, Joel Gelernter, @daniposthu.bsky.social,

12/ Thank you to our amazing co-authors and the cohorts whose data made this study possible! Holly Poore, @dielondono.bsky.social, Yuchen Ning, Natasia Courchesne-Krak, @maiachoi.bsky.social, Justin Tubbs, Matthew Rosenblatt, Peter Tanksley, FazilAliev, @nateyates.bsky.social,

11/ GWAS summary statistics will be released at publication, with and without 23andMe data. We’re excited to see the new insights and discoveries that follow! 🎉

10/ This paper maps genes linked to EXT—from common health risks to severe disorders—across two ancestries, implicating early brain development 🧠, key neurotransmitters, and druggable pathways. We also developed a predictive PGI that helps clarify how EXT relates to myriad outcomes! 🧬

9/ The EXT PGI was also associated with diverse medical outcomes across the lifespan, underscoring the clinical relevance of this genetic signal.

8/ The EXT polygenic index (PGI), which measures a person’s genetic risk for externalizing, explained up to ~12% of the variance in EUR-like samples and ~3% in AFR-like samples. PGIs in EUR-like samples were robustly linked to relevant outcomes (figure), including within families!

7/ Drug-repurposing findings further implicate excitatory and inhibitory neurobiology 🧠: EXT signal is enriched among targets of compounds acting at GABA A, dopamine, and glutamate receptors, as well as calcium-channel blockers, identifying pathways for mechanistic follow-up.

6/ At the neuronal level, EXT signal is broadly enriched in GABAergic and glutamatergic systems, across many brain regions and developmental stages, highlighting a key role of synaptic biology that begins early and shapes how neurons connect and communicate.

5/ Externalizing-related genes are expressed broadly throughout the brain 🧠, but their expression is particularly pronounced during early- to mid-prenatal development.

4/ With such a large and diverse sample, we identified many genes associated with externalizing: Across 1,294 genomic loci and 647 fine-mapped SNPs, we pinpointed 961 effector genes, including known biology (e.g., CADM2, BDNF) and novel discoveries (e.g., SLC17A6, NRN1)!

3/ Externalizing isn’t just about substance use—its genetic architecture is also related to antisocial behavior, borderline personality disorder, suicide attempt, health-risk behaviors, and certain personality traits like impulsivity!

2/ We find that EXTernalizing has a similar genetic basis across ancestries, even when measured using slightly different traits, and that genetic correlations with other traits are broadly similar across ancestries.

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction - Nature Neuroscience This paper identified >500 genetic loci associated with behaviors and disorders related to self-regulation, including addiction and child behavior problems. The resulting genetic risk scores predic...

1/ Prior work modeled the genetic overlap across externalizing disorders and behaviors with a single EXT factor: doi.org/10.1038/s415.... Here, we expand the EXT GWAS to larger and more diverse samples.

Genomic insights into substance use and disinhibitory disorders Externalizing spectrum disorders- spanning attention-deficit/hyperactivity disorder, conduct disorder, substance use disorders, and other disorders characterized by disinhibition - frequently co-occur...

Our multi-ancestry GWAS of EXTernalizing conditions (ADHD, substance use...) in ~4M people reveals neurodevelopmental risk, drug-repurposing targets, and yields one of the strongest psychiatric polygenic indices yet! 🧬🎉 doi.org/10.64898/202...

Extremely excited to share the first effort of the Revived Genomics of Personality Consortium: A highly-powered, comprehensive GWAS of the Big Five personality traits in 1.14 million participants from 46 cohorts. www.biorxiv.org/content/10.1...

here's one that we put online:
neuroanatomy.github.io/cortex/
(takes freesurfer curv data as input or tables with values. Used by @cognitivecamz.bsky.social !)

Comparison of the multivariate genetic architecture of eight major psychiatric disorders across sex - Nature Genetics Genomic structural invariance, an extension of genomic structural equation modeling, identifies similarities and differences between males and females in the genetic architectures of eight psychiatric...

Out today, our method for comparing multivariate genetic architecture across groups of people, called Genomic Structural Invariance: www.nature.com/articles/s41...

(feat: @tuckerdrob.bsky.social @michelnivard.bsky.social @andrewgrotzinger.bsky.social @mijke.bsky.social @jorsmo.bsky.social et al.)

Genetic correlations between MDD and each neuroticism cut point. The line of best fit is shown, based on a linear regression model, with parameters estimated using generalized least squares (GLS).

Standardized results (with standard errors) for two-factor genomic structural equation model as estimated using GenomicSEM software.

Standardized results (with standard errors) for three-severity factor genomic structural equation model as estimated using GenomicSEM software.

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity and differentiation of traits across the severity spectrum. Tweetorial coming soon.

Le magazine Parents ressort la fausse information de l’intelligence qui serait transmise par la mère, et est immédiatement recopié par Marie-France et MSN.
🧵

Santé mentale : les liens génétiques et cliniques cachés entre certains troubles psychiatriques Une étude s’intéresse aux similitudes génétiques et cliniques entre différents troubles psychiatriques pour, à terme, mieux soigner ceux qui souffrent de plusieurs pathologies en santé mentale.

Quels sont les liens entre les différents troubles mentaux? Dans quelle mesure sont-ils dus à des facteurs génétiques communs?
Cet article tente d'éclairer ces questions sur la base d'une de nos dernières études, menée par @cognitivecamz.bsky.social et publiée cet été:

Hidden Links: The Common Threads of Mental Health Disorders In many illnesses, having one symptom makes you much more likely to have others. Such as, individuals with diabetes are more likely to also have hypertension. The same is also true for mental health d...

Blog post discussing a key finding from our recent Nature Mental Health paper: Genetically similar disorders don’t always have the highest symptom overlap or co-occurrence 🧬

Blog: adaa.org/learn-from-u...

Paper: www.nature.com/articles/s44...

Congrats!! 🎉

Studying sex differences in the human brain is challenging, but important.

Many thanks to @emilysingerneuro.bsky.social & the fab folks @thetransmitter.bsky.social for inviting me to contribute to the evolving conversation on this timely topic ⬇️

1/n

Call for Submissions: Behavior Genetics Special Issue on Public Science Call for Submissions: Behavioral Genetics as a Public Science: Impacts and Implications Journal: Behavior Genetics Aim and Scope: Genetically informed studies of human behavior captivate a broad a...

🚨Call for submissions!🚨

We're organizing a special issue on "Behavioral Genetics as a Public Science"🧬🌍

Relevant topics include:
-Public outreach and education
-(Mis)use and (mis)interpretations of BG research
-Ethical, legal, and social issues

tinyurl.com/bgpublicscie...

Thanks for this! Would love to be added

a couple of cartoon characters standing next to each other with one wearing a purple earring Alt: a couple of cartoon characters standing next to each other with one wearing a purple earring

📣 Big news! Our tag-team effort on common variants in rare neurodevelopmental conditions is now out in Nature 📣

Co-first authoring with the brilliant Qinqin Huang🌟—proof that teamwork does make the dream work. 💪 www.nature.com/articles/s41...