Delighted to announce @tlhr.bsky.social, @g-heller.bsky.social and I are building the UK’s first FRO @bindresearch.org with the goal of making disordered proteins druggable. Interested in doing breakthrough open science in an innovative organisation in Central London? We’d love to hear from you!

Today @gogs-k.bsky.social, @tlhr.bsky.social, and I are launching @bindresearch.org, a UK-based not-for-profit research startup to deliver publicly–available tools and datasets to make intrinsically disordered proteins druggable. 🍝 💊🧲 💻 🦠

Combined NMR and Deep Neural Network approach enhances resolution of protein aromatic side chains FID-Net-2, a deep learning model, enhances the resolution of 1H-13C NMR spectra for aromatic side chains. It offers detailed structural and dynamic insights that improve NMR analysis in structural bio...

Breakthrough, led by D. Flemming Hansen @dflemminghansen.bsky.social @uclofficial.bsky.social and colleagues, addresses current challenges in obtaining high-resolution NMR spectra for aromatic residues www.ucl.ac.uk/lifesciences... #NMRnews #NMRchat #NMR 🧲

Open #PhDposition: decipher the mechanisms underlying allostery.

What allows a protein to communicate over many nanometers to regulate its function? How did it evolve? What is the link to protein dynamics?
Join us to study exciting mechanisms by NMR & more.

More info attached.
phd.pages.ista.ac.at

I have some at 500 and 800 - including raw time domain data. Please DM

A combined NMR and deep neural network approach for enhancing the spectral resolution of aromatic side chains in proteins Combining developments in deep learning and NMR opens up opportunities like high-resolution aromatic spectra from protein samples.

Tailored NMR experiments combined with a new DNN provide high-resolution spectra of aromatic side chains and accurate uncertainty estimates - enabling quantifications of dynamics and kinetics

doi.org/10.1126/scia...

#ScienceAdvances @crick.ac.uk @uclofficial.bsky.social @ukri.org

#NMRchat

Proline cis/trans is one of these examples. Small amplitude, normally quite slow, but can have a large impact on protein function, folding, and binding.

Apparent C2V symmetry and correlated motion

Chemical Exchange & Sparsely Populated States in #NMR by Guillaume Bouvignies from @cnrs.bsky.social @normalesup.bsky.social

All the cool details that are normally left out are revealed this morning !

Excellent tutorial on artificial intelligence in magnetic resonance presented by Ilya Kuprov at the @rsc-nmrdg.bsky.social Winter meeting #nmrchat

Interesting talk by Prof Poul Erik Hansen about how NMR deuterium isotope effects can report on hydrogen bonding and salt bridges at the annual NMRDG winter meeting.

@rsc-nmrdg.bsky.social
#NMRchat

📣📣 XIVth international conference on #NMR a tool for biology. May 26-28, 2025 @pasteur.fr Paris, France. The registration is open 👉 www.nmr2025.conferences-pasteur.org
Coorganized with
@brukercorporation.bsky.social

Hi Team #NMRchat #NMR. Happy to see you out here!

Let's start spreading the word about the ENC-ISMAR Joint Conference, April 6-10, 2025.

Oral Abstract Deadline: January 10

www.enc-conference.org/enc-ismar-2025

Are you a student or postdoc planning to attend the ENC-ISMAR Joint Conference?

We have awards and stipends available to support your travel.

All you neeed to do is apply! January 10 deadline. Giddy-up!

Details: www.enc-conference.org/Awards

#NMRchat #NMR