Check out this important advance in mitochondrial 🧬 lineage tracing by @gaoteng.bsky.social and @wengchen.bsky.social from our group, in collaboration with @jswlab.bsky.social 👇👇

GitHub - teng-gao/mitodrift: Reconstructing single-cell lineage history using mitochondrial mutation drift dynamics Reconstructing single-cell lineage history using mitochondrial mutation drift dynamics - teng-gao/mitodrift

MitoDrift is available on GitHub (github.com/teng-gao/mit...). More tutorials coming soon!

We turned to population genetics for a solution. The resulting approach, MitoDrift, integrates Wright-Fisher drift dynamics with phylogeny inference via a hidden Markov tree model, enabling us to produce confidence-calibrated lineage trees.

Mitochondrial lineage tracing brought exciting new capabilities to single-cell genomics. However, a core problem remains: unlike classical lineage recorders, mtDNA mutations can drift and disappear as cells divide, preventing us from precisely decoding lineage history.

GitHub - teng-gao/mitodrift: Reconstructing single-cell lineage history using mitochondrial mutation drift dynamics Reconstructing single-cell lineage history using mitochondrial mutation drift dynamics - teng-gao/mitodrift

MitoDrift is available on GitHub (github.com/teng-gao/mit...). More tutorials coming soon!

We turned to population genetics for a solution. The resulting approach, MitoDrift, integrates Wright-Fisher drift dynamics with phylogeny inference via a hidden Markov tree model, enabling us to produce confidence-calibrated lineage trees.

@biorxivpreprint.bsky.social Modeling mitochondrial inheritance enables high-precision single-cell lineage tracing in humans
www.biorxiv.org/content/10.6... @bloodgenes.bsky.social @jswlab.bsky.social @bostonchildrens.bsky.social @hhmi-science.bsky.social @broadinstitute.org