Excited to share our latest work in Nature. Applying single-molecule and single-cell DNA sequencing methods, we uncover an extraordinary landscape of somatic mutations in immune checkpoint genes in autoimmune B cells, suggesting that somatic mutations may be key to autoimmunity [1/n] rdcu.be/fdqbr

Carl de Boer on understanding the evolution of gene regulatory complexity and its role in complex disease #MITS2026

Isidro Cortes-Ciriano on small molecule cell-free DNA sequencing at national scale #MITS2026

@nevillesanjana.bsky.social

Neville Sanjana on scalable methods to determine the function of noncoding DNA and RNA #MITS2026

Paper here www.nature.com/articles/s41...

A whole new world… Inigo Martincorena presents paradigm shifting work showing a key role for somatic evolution in autoimmune disease. Long-term, polyclonal, multistage evolution #MITS2026

Nicole Lake on constraint in mitochondrial genomes with insights into health and evolution #MITS2026

Amanda Larracuente on meiotic drive and satellite DNA in drosophila #MITS2026

Talks exploring the heritability of mutational processes and inferring de novo mutation rates across primates #MITS2026

Evan Eichler on using near-complete human genomes to more fully understand mutational processes #MITS2026

Talks on selection in sperm and population differences in germline mutational processes #MITS2026

Siyao Wang on transgenerational inheritance of DNA damage and sex specific effects #MITS2026

Hakon Jonsson on insights into de novo genetic variation and genetic causes of pregnancy loss #MITS2026

Diverse mutational patterns between neuronal populations in the cerebellum #MITS2026

Talks on heterozygosity induced de novos and new indel mutational signatures at #MITS2026

Two more talks on single cell resolved clonal haematopoiesis research and using methylation patterns to study clonality #MITS2026

Caroline Watson gives the first talk at the Mutations in Time and Space conference on the evolutionary road to AML #MITS2026

Delighted to have contributed a comment piece and the cover illustration to a @natecoevo.nature.com focus issue on "Evolution in medicine".
I discuss how the emerging field of somatic evolution is providing new opportunities to understand disease and promote healthy ageing doi.org/10.1038/s415...

Thanks Matt!

Curious Cases - Series 24 - Immortal Jellies - BBC Sounds Hannah Fry and Dara Ó Briain ask whether a tiny jellyfish holds the secret to immortality.

Thrilled to announce that I'm on Curious Cases tomorrow at 10am on BBC Radio 4!

The episode - Immortal Jellies - looks at some remarkably long-lived species and what they can teach us about ageing. This is a key area of focus for our lab.
www.bbc.co.uk/sounds/play/...

Julie Ahringer from @gurdoninstitute.bsky.social @geneticscam.bsky.social @cam.ac.uk gives talk on decoding genome regulation during development. Exploring how chromatin accessibility changes throughout development enable single cells to become multicellular organisms.

This is a fantastic opportunity to do exciting research on comparative somatic evolutionary genomics as part of a great team. I've collaborated with Peter for many years and highly recommend this position! Please email Peter if you'd like to learn more, including a copy of your CV.

Love seeing methodical comparisons of preservation protocols like this! Great to know for the future

night science

Thanks @trevorgraham.bsky.social it was an honour to participate in this great workshop with such an engaged and diverse cohort in a rapidly growing community

Closing keynote from the fabulous @atjcagan.bsky.social on "The impossibility of whales" discussing somatic mutagenesis across species. Brilliantly delivered and exceptionally illustrated talk, as anyone who knows Alex's work would expect! #EBECancer25
@eventswcs.bsky.social

Thanks @amyboddy.bsky.social for the invitation to run this workshop on where ideas come from in science, barriers to creativity and how to overcome them. Great discussion from the group! I'm a convert to 'night science' @urialonlab.bsky.social

The Somatic Mosaicism across Human Tissues Network @nature.com @timcoorens.bsky.social
www.nature.com/articles/s41...

A signature-agnostic test for differences between tumor mutation spectra reveals carcinogen and ancestry effects Mutational signatures contain valuable information about the mutational processes shaping cancer genomes. However, despite dozens of tools to identify signatures in cancer samples, there is not an est...

If you’ve ever wondered about the statistical significance of differences among mutational signature profiles, check out our new Aggregate Mutation Spectrum Distance (AMSD) preprint co-led by Sam Hart and @alisonfeder.bsky.social with @nalcala.bsky.social www.biorxiv.org/cgi/content/...