Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models Ector et al. uncover circadian heterogeneity across neuroblastoma cell models and link rhythmic strength to drug sensitivity. Their findings suggest that circadian competence may influence treatment outcomes, pointing to chronotherapy as a potential avenue for improving pediatric cancer care.

Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models

Circadian rhythm heterogeneity modulates drug response variations in neuroblastoma models Ector et al. uncover circadian heterogeneity across neuroblastoma cell models and link rhythmic strength to drug sensitivity. Their findings suggest that circadian competence may influence treatment o...

It’s a wrap! My final PhD paper in the @granadalab.bsky.social just came out in @cp-cellreports.bsky.social 🥳 Here, we identified circadian rhythm heterogeneity and distinct time-of-day drug sensitivity dynamics across neuroblastoma cell models ⏰ Thanks to everyone who shaped this work! rb.gy/j7z0sj

ML uncovers 24h rhythms in cancer 🕒🧬
Using COFE ☕, we reconstruct #circadian rhythms from human tumor biopsies across 11 #cancer types!
Turns out, tumor #clocks tick in a different timezone 🕰️💊
Got data? Let’s connect! 🤝
#AIforHealth #CircadianMedicine #oncology

Outside-in regulation of cellular clocks - Nature Physics Circadian clocks and cell division cycles are coupled. Now a study shows how cell-to-cell synchronization of circadian rhythms regulates cell division and growth.

@granadalab.bsky.social recently showed how circadian coupling regulates cell growth. In order to regulate the cell on the inside, we should look outside! Great pleasure to write News&Views together with Jae Kyoung Kim! @mpinb.mpg.de

www.nature.com/articles/s41...

Thank you, Neha. Greetings to Tübingen!

Proud moment to see work from my PhD in the @granadalab.bsky.social featured on the cover of the April 2025 issue of @molsystbiol.org 🥹 special thanks to my talented husband who helped design this cover. Check out the full paper here: lnkd.in/eDVQuRfc.

New work out in @naturephysics.bsky.social
Led by @NicaGutu & Malthe Nordentoft + great collaborators.

We show that circadian synchrony shapes cell growth. When coordination is lost, clock–cell cycle coupling breaks down.

May help explain paradoxes in circadian cancer biology.
📖 rdcu.be/efNaY

Our latest work is out in @commsbio.bsky.social
Led by Nica Gutu & Hitoshi Ishikuma, we show how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Supported by @Charité, @BMBF_Bund, @emed-sysmed.bsky.social Read: rdcu.be/ee3FQ
#chronotherapy #circadian

New research suggests the circadian clock influences breast cancer cell drug sensitivity ➡️ www.embopress.org/doi/full/10....

Circadian clock features define novel subtypes among breast cancer cells and shape drug sensitivity | Molecular Systems Biology imageimageDeep circadian phenotyping across breast cancer cell lines reveals distinct circadian subtypes and their impact on drug responses. Novel circadian-based subtypes are established among breast cancer cell models. Deep circadian ...

Happy to share a new very exciting work from my lab! Congrats to CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @molsystbiol.org.
We identified novel circadian subtypes linked to drug sensitivity 💊
www.embopress.org/doi/full/10....

Chronobiologie in der Onkologie: Onkologische Therapien am besten zur individuell optimalen Tageszeit – Deutsches Ärzteblatt

🚀 Together with Carolin Ector, we recently published a review in the German medical journal Deutsches Ärzteblatt! 🎉

Topic: Chronobiology in Oncology ⏰💊

📌 Currently only in German

🔗 www.aerzteblatt.de/archiv/chron...

#Oncology #Chronobiology #MedicalResearch #CancerTreatment #HealthInnovation