"Implement protocols." Priceless.

Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression Liao et al. developed a compound that selectively degrades TBK1, a kinase playing critical roles in kidney tumorigenesis. By destroying the protein rather than just blocking its activity, this approach inhibits kidney cancer progression efficiently and uncovers new mechanistic insights into TBK1-dependent oncogenic signaling.

Online now! Online now! Selective degradation of TBK1 uncovers mechanistic insights into blocking ccRCC progression #chembiol

"Laptop class doctors" -- 10/10, take all the stars. I will now use this on a daily basis and reference you.

"Asthma" is an imprecise, unhelpful, archaic term that should go the way of "dropsy" and "consumption".

Co‐Culture Systems to Study Epithelial‐Immune Interactions During SARS‐CoV‐2 Infection Robust inflammatory responses to viral infection are mediated by immune cell populations, including monocytes and dendritic cells. However, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2...

I've gotten lots of questions about our co-culture systems to study epithelial-immune interactions in viral infections, so wrote a step-by-step guide! I hope this will help anyone looking to adapt these protocols for their research.
currentprotocols.onlinelibrary.wiley.com/doi/abs/10.1...

Ceasefire The brain of one human child will hold over 2.5 quadrillion bytes of information. 2.5 quadrillion memories that will never be again— (Sunday morning, father in the orange trees, the way the stars appeared to only her.) When you kill a child you kill all the stars in the world. —Joseph Fasano

for a certain madman who thinks nothing of threatening the destruction of a "whole civilization"

"The Overlooked Kinase Isoform Gets a Date to Prom"

"Tristan Strong Punches a Hole in the Nuclear Membrane"

I saw a group post this and have to say that it is amazing.

OpenAI announces ChatGPT is now at the level of real scientific reviewers, “It just tells you to do single-cell RNAseq in response to every query” says Sam Altman

It is impossible to imagine Eisenhower saying he would fight “without mercy” even against the Nazis; nor would he have reveled in the thought of death and destruction.

He would have regarded it not only as deeply un-American but also beneath his dignity as a serious career soldier.

Microbes might be able to planet hop on asteroid shrapnel Experiment confirms bacteria could survive being blasted off world by impact

To simulate an asteroid impact in the lab, researchers put bacterial cells on a membrane and shot them with a gas-fired projectile that struck the microbes at up to 480 kilometers per hour. The bacteria largely shrugged off the cataclysm. Cool story by @jakebuehler.bsky.social at @science.org

A comparative analysis of the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models www.biorxiv.org/content/10.64898/2026.02...

Your anti-ageing stack should include this vaccine The shingles vaccine seems to reduce the risk of dementia. There is speculation that it might slow down ageing

We live in a bizarre world where longevity influencers tell millions to take rapamycin, sit in hyperbaric oxygen chambers, blast themselves with red light therapy, and take 50+ supplements daily. Meanwhile something that cuts dementia risk by 20% Is invisible.

open.substack.com/pub/overmatt...

I am an Epic Chat conscientious objector (ICU, not ID) for 2 reasons. 1- It is a constant interruption. 2- Communication (big C) is important and Epic Chat is usually low quality (little c) communication. If someone needs to talk to the ICU there are many ways and Epic Chat is not the right one.

Don't give up!

On the one hand, I think it's great that someone mapped Bluesky users. On the other hand, I'm a bitworried that I map at some kind of Lagrange point between "Biomedical Research Scientists" (totally makes sense) and..."Brazilian Young Adults on Bluesky". Where's the cycling group?

Jeff Bezos clarifies that newspapers also die in darkness

News In Photo:

I like my thylakoids the way I like my pancakes:

Stacked so densly it causes iridescence and apprears blue when lit at the right angle.

Honestly. There is no easy fix to <waves in GenX> alla this. But a starting place could be to address the CRIME of Citizens United. Corporations are NOT people. Money is NOT speech. And the place we're in right now? Owes a LOT to those two things being perverted by Citizens United.

We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n

How does SARS-CoV-2 infection lead to dysregulation of the immune system in severe and #LongCovid?
An unanticipated mechanism described @pnas.org with depletion of specific immune T and dendritic cells, open-access
www.pnas.org/doi/suppl/10...

There must be an ICU snack that treats the headaches.

Spicy kimchi on baked potato.

As with Shakespeare, I always found myself coming out of a Stoppard play feeling more intelligent than when I went in.

A display of cheeses. Two in the front are vaguely torus shaped, sliced in half so you can see the shape, like a bagel cut in half to make two u-shapes. They look like drawings of the disk of matter around a black hole, narrow in the middle and flared on the outside.

For the astronomers: I found an accretion disk diagram cheese. A quesar.

A screen shot of the antibiotic personality quiz

It’s World AMR Awareness Week, and this year I had the honor to re-imagine and doodle the antibiotics in the antibiotic personality quiz 😇🖍️
Thank u @brxad.bsky.social for this amazing and fun opportunity!

C’mon, take the quiz, it’s a #WAAW tradition 😉💊
#IDSky

quiz.tryinteract.com#/59e68e3a8ec...

My residency director used to say never have more than 2 if you're on call.