Richard Hewitt (@drrjhewitt) Bsky

Well done Jenny!!! Many congratulations - very well deserved.

4 months ago 2 0 0 0

New study on pulmonary fibrosis highlights changes in immune/epithelial cell communication in the lung

publications.ersnet.org/content/erjo...

Thank you Richard @drrjhewitt.bsky.social for allowing me to participate

5 months ago 3 1 0 0

Single-Cell RNA-seq Reveals Aberrant Airway Epithelial-Immune Cell Crosstalk In Pulmonary Fibrosis BackgroundEpithelial-immune cell interactions are crucial in the regulation of pulmonary immune responses. Emerging evidence suggests that cell populations lining the airways may play a pivotal role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a disease characterised by progressive scarring of the lung parenchyma. We profiled the cellular landscape of the airway mucosal niche in incident cases of IPF to understand early-stage events contributing to disease development.MethodsSingle-cell RNA-sequencing was used to explore cellular heterogeneity in proximal airway brushings from seven healthy controls and nine patients with newly diagnosed IPF. In-depth bioinformatics analysis was used to interrogate changes in cell populations and cell-cell communication in IPF patients compared to controls.ResultsWe show a relative increase in the abundance of airway macrophage subsets in IPF compared to healthy controls, and disease-specific changes in their transcriptional profile. Increased frequency of airway macrophages and proliferating macrophages was associated with more extensive disease at baseline quantified by the composite physiological index and radiological severity of traction bronchiectasis. Monocyte-derived macrophages were significantly enriched at baseline in IPF patients who had disease progression at 12 months. Using CellChat we exposed differences in cell-cell communication between airway epithelial cells, airway macrophages and T cells in IPF. We identified dysregulation in signalling pathways such as SEMA3, ANXA1 and DESMOSOME which modulate airway epithelial-macrophage interactions, potentially driving disease pathology.ConclusionsAirway epithelial cells and macrophages may play a key role in orchestrating the early immunopathology of IPF, and these data support further exploration of novel, airway-focused therapeutic targets in IPF.

publications.ersnet.org/content/erjo...

4 months ago 2 0 0 0

Thanks Jenny!

4 months ago 0 0 0 0

Delighted to share our latest study published in ERJ Open Research.
publications.ersnet.org/content/erjo...

This research provides novel insight into early epithelial and immune aberrations in the airway in IPF and underscores the potential for airway-focused therapeutic approaches in the future.

5 months ago 2 0 2 1

Last 2 days to apply for this exciting postdoc position investigating early lung fibrosis at @kingscollegelondon.bsky.social - please do consider!

8 months ago 0 0 0 0

New postdoc position in my lab investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Closing date 7th August.

Please do consider applying!

my.corehr.com/pls/coreport...

8 months ago 4 4 0 1

Epithelial damage and ageing: the perfect storm Background Idiopathic pulmonary fibrosis (IPF) is a progressive disease of lung parenchymal scarring that is triggered by repeated microinjury to a vulnerable alveolar epithelium. It is increasingly r...

Our Review just published in Thorax takes a fresh look at how ageing-associated cellular changes lead to epithelial dysfunction and vulnerability, priming the development of pulmonary fibrosis. @jennydickens41.bsky.social @lpearmain.bsky.social

thorax.bmj.com/content/earl...

10 months ago 4 2 0 0

Interested in lung epithelial ageing in IPF? Check out our new review - just landed in Thorax @drrjhewitt.bsky.social @lpearmain.bsky.social thorax.bmj.com/content/thor...

10 months ago 8 5 0 0

Huge congratulations Jenny! Very well-deserved.

10 months ago 0 0 0 0

A bar chart showing the change from baseline in forced vital capacity at week 52 in the overall trial population

In the FIBRONEER-IPF phase 3 trial, nerandomilast slowed disease progression in patients with idiopathic pulmonary fibrosis as compared with placebo. Full trial results: nej.md/4mgWcIU

#ATS2025 @atscommunity.bsky.social

11 months ago 26 10 0 0

Postdoctoral Research Associate at King's College London An opportunity for an academic position as a Postdoctoral Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

New postdoc position investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Please do consider applying:
www.jobs.ac.uk/job/DLS668/p...

Closing date 18th Feb.

1 year ago 2 4 0 0

Postdoctoral Research Associate at King's College London An opportunity for an academic position as a Postdoctoral Research Associate is available, as advertised on jobs.ac.uk. Apply now and explore other academic job openings.

New postdoc position investigating interstitial lung abnormalities (ILA) and mechanisms driving early lung fibrosis @kingscollegelondon.bsky.social @rbandh.bsky.social @gstt-nhs.bsky.social @crick.ac.uk

Please do consider applying:
www.jobs.ac.uk/job/DLS668/p...

Closing date 18th Feb.

1 year ago 2 4 0 0

Qualtrics Survey | Qualtrics Experience Management The most powerful, simple and trusted way to gather experience data. Start your journey to experience management and try a free account today.

We’re conducting a quick, anonymous survey to better understand current practices for managing interstitial lung abnormalities (ILAs) in the UK. Your insights can help improve care pathways and outcomes.

⏱️ Takes just 5 minutes to complete!

👉 tinyurl.com/ytsupxwk

Thanks

1 year ago 4 2 0 0

I agree!

1 year ago 0 0 0 0

Thanks Naftali. Please include me! Happy new year!

1 year ago 0 0 0 0

Posts by Richard Hewitt