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Posts by Fromme Lab

Flyer describing the Small GTPase conference, register at this URL:
https://events.faseb.org/event/Small-GTPases/summary

Flyer describing the Small GTPase conference, register at this URL: https://events.faseb.org/event/Small-GTPases/summary

1 week left to submit an abstract to be considered for a talk at the FASEB GTPase conference:

events.faseb.org/event/Small-...

1 day ago 1 1 0 0
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On April 19, 1898, Camillo Golgi first described what we now call the Golgi apparatus - a structure so striking and unusual that it took more than 50 years for scientists to accept it wasn’t just an artefact.

April 19 is #GolgiDay! Celebrate the cell’s most iconic and best organelle.

3 days ago 49 11 2 2

Another fantastic #GolgiTime paper from the Glick lab!

4 days ago 4 1 0 1
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Meiotic prophase I disruption as a strategy for nonhormonal male contraception using small-molecule inhibitor JQ1 | PNAS Developing safe, reversible, and nonhormonal male contraceptives has been hindered by the lack of defined biological windows that can be transientl...

Very proud of this tour de force from two former students, Stephanie Tanis and Leah Simon, with help from a huge team, including @charlesdanko.bsky.social highlighting a novel-overlooked intervention point for male contraception

www.pnas.org/doi/10.1073/...

1 week ago 14 8 0 0
The eukaryotic homology search complex distorts donor DNA structure to probe for homology A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

Very exciting that our new paper on the forces exerted by the Rad51-Rad54 homology search complex is now online. This was a collaborative effort with the Wang here at Cornell, and this work performed primarily by a graduate student, Mitch Woodhouse
genesdev.cshlp.org/content/earl...

1 week ago 26 9 4 0
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We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

2 weeks ago 14 25 1 0
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The 2026 Otto Warburg Medal winner Maya Schuldiner received the medal from @volkerhaucke-lab.bsky.social after a moving laudatio by Christian Ungermann Thanks to @elsevierconnect.bsky.social for the continuous support!

3 weeks ago 43 8 0 1

Yes!!!

3 weeks ago 0 0 0 0
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And here is the working URL!

events.faseb.org/event/Small-...

3 weeks ago 1 1 0 0
Poster for the FASEB GTPases conference, June 21-24, 2026, in Melbourne, Florida.

Poster for the FASEB GTPases conference, June 21-24, 2026, in Melbourne, Florida.

A reminder for all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 21-24 in Florida, USA.

The deadline to be considered for a short talk is April 27.

events.faseb.org/event/Small-...

3 weeks ago 1 0 0 1
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I've been leading a big project at Methods in Enzymology over the past year or so: editing three back-to-back-to-back volumes of articles describing the latest advances in methods for studying lipids and membranes — thank you to the 50 #lipidtime luminaries who contributed the 51 chapters! Details 👇

1 month ago 69 17 4 1

💘

2 months ago 2 0 0 0

Congratulations!

2 months ago 1 0 0 0

Love it

2 months ago 2 0 0 0

Thank you, Alex!!! It was fun watching @rvig.bsky.social solve this puzzle

2 months ago 1 0 0 0
The GTPase activating protein Gyp6 binds Retromer and inactivates Rab7/Ypt7 to coordinate the formation of endosomal carriers The Retromer coat is conserved in all eukaryotes and is crucial for the correct intracellular sorting of many transmembrane receptors and lysosomal hydrolases. Retromer is an effector of the late endosomal small GTPase RAB7 and is also implicated in its inactivation required for proper endosomal maturation. Here, we explore the role of controlled GTP hydrolysis by the RAB7 ortholog Ypt7 in the formation of Retromer-coated membrane carriers in yeast. Proximity labelling and genetic ablation identify the GTPase Activating Protein (GAP) Gyp6 as a critical regulator of Ypt7 activity in the context or Retromer. Structural studies show that Retromer recruits Gyp6 through its Vps29 subunit, which recognises a specific PL motif and a secondary binding site in the C-terminal domain of Gyp6. This interaction does not occur with other yeast GAPs. Ablation of the Gyp6-Retromer interface or the catalytic activity of Gyp6 leads to the accumulation of tubular structures on endo-lysosomal compartments and to increased association of Ypt7 with Retromer and its cargo Vps10. These results support a model in which Gyp6 controls the switch from Ypt7-dependent Retromer coat assembly and cargo collection to the departure of the carrier through membrane fission and uncoating. ### Competing Interest Statement The authors have declared no competing interest. National Health and Medical Research Council, https://ror.org/011kf5r70, APP2016410 Swiss National Science Foundation, https://ror.org/00yjd3n13, 31003A_179306, 310030_204713, 10.006.083

Do you want to know more about how Retromer regulates Rab7 activity in yeast? Of course you do. Check out the new collaboration with Andreas Mayer with work led by Catarina Alves and Kevin Chen.

2 months ago 20 10 0 0

Weill Institute is recruiting postdocs, please share!

Fischer Lab: lnkd.in/eMnveqyv

Hu Lab: lnkd.in/epsGK7wd

2 months ago 4 6 0 0
Conference flyer listing confirmed speakers and attendees

Conference flyer listing confirmed speakers and attendees

Calling all GTPase enthusiasts! The 2026 Regulation and Function of Small GTPases FASEB conference will be held June 22-24 in Florida, USA.

events.faseb.org/event/Small-...

3 months ago 4 4 0 0
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So in awe of our neighbors, another important study from the Baskin lab using such powerfully clever and elegant tools.

Feeding-Fishing for the win!

3 months ago 6 3 0 0

Awesome opportunity!

3 months ago 2 0 0 0

Thank you, Lydia!

3 months ago 0 0 0 0

Thank you, Fran! The Arfs are so powerful they need more regulators 😀

3 months ago 1 0 0 0

We are so happy that @tarafisch.bsky.social has joined us at Cornell !!!

3 months ago 3 1 1 0
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Weill Institute welcomes Tara Fischer as newest research member | Cornell Chronicle Fischer investigates how cells detect and repair organelle damage, and how these processes influence inflammation and the progression of neurodegenerative disease.

We are absolutely THRILLED to welcome our newest faculty member @tarafisch.bsky.social to the @weillinstitute.bsky.social community. We look forward to the exciting and impactful work ahead!

news.cornell.edu/stories/2026...

3 months ago 21 8 0 2

Thank you, Jeremy!

3 months ago 1 0 0 0

Excited to start 2026 out with a new manuscript from our lab, please check out this thread from superstar postdoc @rvig.bsky.social about how he discovered the function of a conserved secretory protein, and how this also led him to the identification of a new family of GAP proteins!

3 months ago 17 6 2 0
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Thank you, Brett!!

3 months ago 1 0 0 0
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Check out our new biosensor technology to study DDR kinase signaling: ProKAS.

We combine:
-proteomics
-engineered peptide sensors
-a new concept of amino acid barcodes

ProKAS tracks kinase signaling with spatial resolution and produces highly quantitative data.

Just published today: rdcu.be/ePNo0

5 months ago 20 7 2 1

Sarah and the Cohen lab are doing amazing work!!!

5 months ago 6 0 1 0
Scaling back DEI programmes and the loss of scientific talent - Nature Cell Biology Programmes that support diversity, equity and inclusion (DEI) in science are under attack in the USA. Data indicate that diversity in the scientific workforce increases creativity and success in tackl...

Important article from @marymunson4.bsky.social @joann-trejo.bsky.social @needhibhalla.bsky.social

5 months ago 9 9 0 0