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About one quarter of the 20659 proteins in the human proteome have TMDs. Most have 1 TMD, there's about 1000 with 7 TMDs. Details are in the post, which is linked.

How many proteins in the human proteome have transmembrane domains? And of those, how many examples with n TMDs are there?
Couldn't find an answer, so I calculated it from Uniprot data with some #RStats magic (and I did some model organisms while I was at it). 🧪

quantixed.org/2026/04/16/m...

1. The paper with the implausibly large effects of Omega-3 fatty acids on mental health was now retracted. A little thread on the process where @ianhussey.mmmdata.io and I was involved.
www.sciencedirect.com/science/arti...

A screenshot of a white-on-black terminal depicting a 19x19 go board in ascii graphics, with empty grid intersections as periods, and black and white as Os and #s

It’s absolutely incredible that one of the largest Japanese-run Go servers, which has been running since 1992, is still accessed entirely via Telnet. And while most players use GUI clients that use Telnet under the hood, you can still connect manually and get ASCII graphics streamed to you

ERC President explains stricter application measures amid rising demand for funding The text of an open letter sent by ERC President Maria Leptin to ERC panel members, grantees and other stakeholders on 16 April 2026.

Here you go:

erc.europa.eu/news-events/...

It's. Unfortunately faculty jobs are more likely to go to those who has those papers and many of us may get fired from faculty jobs if we don't get them... So we also have to be aware of the business context we live in.

Spanish PM Pedro Sánchez: “Here in Spain, we are approving and advancing a process to regularise half a million immigrants.

“And I want to say to the Right and the Far Right who oppose this: Spain is the daughter of migration and will not become the mother of xenophobia.”

Feels like this paper on protein-templated DNA synthesis by a natural enzyme warrants some comment.
So here's a 🧵. /1
www.science.org/doi/10.1126/...

We all known A*azon tends to sell books bellow list prices, but I've recently found them selling books at below WHOLESALE prices. I know this because I own a store. That's fucked up.
Anyways, support your local book stores. Shit's tough.

I laughed

Thinking about this more, the 2 and 3 year bans are real career killers… who’d hire a tenure track candidate, or an (associate) professor that has one of those hanging around their necks?

Congrats on “opening” a strait that was open six weeks ago, and all it cost was at least 13 dead service members, thousands of dead Iranian civilians, tens of billions in taxpayer dollars, our loss in global standing, and the Iranian regime’s increase in power. Phenomenal work.

This is a well-documented pattern in medical research and reflects systemic gender bias in pain assessment and treatment.👇

Yes indeed ..the bird understands water displacement

go home biology, you’re drunk.
reverse transcriptase is now taking sequence instructions from a protein

Brussels launched an age checking app. Hackers say it took them 2 minutes to break it. Cyber experts say they have found holes in Brussels' age verification app, despite claims by the EU executive that it is "technically ready.”

Brussels launched an age checking app. Hackers say it took them 2 minutes to break it.

That would ban many of us from applying. Not that I'll ever get one of these grants, but my institution limits what I can apply based on whether they pay indirect. So only those in big/wealthy institutions will be allowed to apply. As someone else said, that's called the Mathew effect.

This renewed system:

- Punishes people for taking any real risk (so much for funding high-risk research!).

- Wastes applicants' time (still have to write that B2, baby! Even if no one reads it and you get banned!)

- Reduces mental well-being of ECRs... Yet another notch lower.

If they didn't want us treating grant applications and the research funding adquisition system as a lottery, they shouldn't be running a lottery system with more fundable grants than money.

Siri, what's the Matthew Effect?

Screen grab of an email from jobs.ac.uk saying there have been no new jobs in Politics in the last 3 months

C'mon jobs.ac.uk , I know things are bad but this is ridiculous

📣 New preprint: Plasma proteomics improves prediction of recurrent cardiovascular events www.medrxiv.org/content/10.6...

Wonderful work with Yang Liu, @sritchie73.bsky.social, and many at @cambridge-ceu.bsky.social

Perfect name for something you use for your science and not give any credit

I'm sure people will wrongly use this to insult Mamdani's wife. What it should do instead is open a larger conversation about how little we value art in our society, and how many talented artists can only create if they have family support, and how much valuable art we are not getting as a result.

Nothing encourages me to write a manuscript quite like a deadline for a different, more important manuscript.

What are your thoughts on volcanologist? 😁

It’s official: the UK is rejoining Erasmus! 👏🇪🇺

How Do You Identify a Good Manager?* Abstract. We introduce and validate a novel approach to identifying good managers. In a preregistered lab experiment, we causally identify managerial contr

How Do You Identify a Good Manager? academic.oup.com/qje/article/...

"people who self-select into management roles perform worse than randomly assigned managers. Managerial performance is strongly predicted by economic decision-making skill but not by demographic characteristics."

Your Kindle's not obsolete, it just needs a jailbreak - and I'll show you how it's done You can transform your old Kindle - even a bricked device - into the ultimate open-source reader. Here's how.

Your Kindle's not obsolete, it just needs a jailbreak — and I'll show you how it's done
You can transform your old Kindle — even a bricked device — into the ultimate open-source reader. Here's how.
www.zdnet.com/article/your...

Who Gets Guggenheims? - Public Books Unfortunately, 100 years of data show that those whom such fellowships might represent the greatest departure from their everyday experience—that is, those not at elite institutions—are least likely t...

Woohoo, here's my essay with my fav co-author on 30,000 fellowship wins across the Guggenheim, Stanford CASBS, NAEd, National Humanities Center, RSF visiting scholar, and Harvard Radcliffe.

Spoiler: it's the people working at prestigious universities

www.publicbooks.org/who-gets-gug...