Image showing the paradigm for recording single neurons in a variety of brain regions in humans, while single-pulse TMS was applied to dlPFC. One subpanel shows that single neurons were able to be resolved very early (8ms) after the single-pulse stimulation. Another subpanel shows two example neuron waveforms, along with their inter-spike interval distributions. The final subpanels show spike density functions overlaid on raster plots for the same neuron, separately for active and sham stimulation, in order to demonstrate that active (but not sham) stimulation increased activity in this example neuron.

We have a new preprint examining single neuron responses in humans undergoing TMS (www.biorxiv.org/content/10.6...). The excellent Charlie Dickey led the way, and I had the privilege to co-supervise this work with @coreykeller.bsky.social and @aaronboes.bsky.social 🧵 (1/7) 🧠🟦 🧠💻

DLPFC TMS suppresses high-frequency neural activity in the human sgACC Repetitive transcranial magnetic stimulation (rTMS) to the dorsolateral prefrontal cortex (DLPFC) is increasingly used to treat major depressive disorder and has demonstrated durable improvements in d...

New paper from @stanfordpntlab.bsky.social in collaboration with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes at UIowa! We explored how TMS to the DLPFC changes neural activity in the subgenual anterior cingulate cortex, a key mood regulator. 1/

Excited to announce award of my K99/R00 "Theta burst modulation of hippocampal-cortical rhythms in schizophrenia," under amazing mentors at Stanford including @coreykeller.bsky.social! We will ask whether hippocampal oscillations can be systematically influenced by stimulation in schizophrenia.

Congratulations!!! 🎉👏🎊 This one is all you @esolomon.bsky.social! Happy and lucky to be a part of it all 🙏

Naturalistic acute pain states decoded from neural and facial dynamics - Nature Communications This study uses brain recordings, self-reports, and facial analysis to decode acute pain in epilepsy patients. Machine learning reveals stable neural markers in mesolimbic, striatal, and cortical regi...

Studying pain without inflicting it on animals 👏

Researchers used EEG, facial expression analysis, & self-reports to track naturalistic acute pain in individuals with epilepsy.

In @natcomms.nature.com
www.nature.com/articles/s41...

#neuroskyence 🧪

We are still hiring! Please do reach out if interested in joining a collaborative and energized team of engineers, psychiatrists, and neuroscientists developing new methods to probe the human brain in an effort to improve our treatments for mental health disorders!

🧠 We are #hiring! Postdoc @stanfordmedicine.bsky.social: help us develop closed-loop EEG platforms to improve TMS treatment for depression! Coding and neuroscience / engineering backgrounds required. Join our team! precisionneuro.stanford.edu email: ckeller1@stanford.edu

Deaths from heart disease down 75%, that’s NIH.

Deaths from stroke down 75%, that’s NIH.

HIV/AIDS no longer a death sentence, that’s NIH.

99% of FDA approved drugs in the last decade, that’s NIH.

Please show this video to anyone who doesn’t understand why the NIH is so important.

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Would love to discuss and collaborate!

🧠 NEW PAPER: How do we capture excitability noninvasively in mood and emotion networks in the human brain? Here, we used real-time optimization to improve these measures!
@sparmi.bsky.social @stanfordpntlab.bsky.social @clinicalneuroph.bsky.social doi.org/10.1016/j.clinph.2025.02.261 1/7

Delighted to share this work by @sparmi.bsky.social @stanfordbrain.bsky.social & our team @stanfordpntlab.bsky.social to improve noninvasive measures of prefrontal excitability!! 🧠⚡️ Soon we can use these to monitor treatments & develop personalize txs for TMS, ketamine, and other interventions

Preprint alert! Check out our latest work in @stanfordpntlab.bsky.social, with @coreykeller.bsky.social @neuro-engineer.bsky.social @esolomon.bsky.social Nick Trapp Aaron Boes (UIowa) 👏

DLPFC Stimulation Suppresses High-Frequency Neural Activity in the Human sgACC Transcranial magnetic stimulation (TMS) to the dorsolateral prefrontal cortex (DLPFC) is hypothesized to relieve symptoms of depression by inhibiting activity in the subgenual anterior cingulate corte...

When we use TMS to treat depression, we think it alters neural activity in a deep brain structure known as the subgenual anterior cingulate (sgACC). But this is hard to test directly, until our preprint with @coreykeller.bsky.social, @neuro-engineer.bsky.social, Nick Trapp, and Aaron Boes (UIowa) 1/

Fantastic work by @esolomon.bsky.social @neuro-engineer.bsky.social & team in uncovering a potential way in which TMS can change neural activity in the subgenual cingulate cortex! Implications for TMS treatment in depression

NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

NIH is the best investment there is.

www.forbes.com/sites/michae...

Interested in leveraging EEG and/or TMS in your research? The Koret Human Neurosciences Community Lab at Wu Tsai Neuro invites Stanford researchers to apply for Human Neuro Pilot grants, awarding up to $10,000 per grant.

Learn more and apply by April 11: neuroscience.stanford.edu/shared-resou...

Highly recommend this important read

How Science Can Adapt to a New Normal Opinion | In the wake of attacks on the research enterprise, scientists need to focus on protecting its fragile infrastructure.

Thought-provoking piece on how scientists may need to pivot to survive and thrive in a new world. Even if you think the status quo will stay more or less intact, this is worth a read.

Congrats to our 2025 Neuroscience:Translate awardees! Their projects support brain imaging and stimulation technologies to improve depression treatment, broaden access to TMS therapy, and advance methods for imaging inflammation in the brain.

Learn more: neuroscience.stanford.edu/news/brain-i...

Universities Are Under Attack. Silence Is Not an Option. University presidents are staying quiet as Trump tries to destroy their institutions. It won't work.

""Many of us didn’t think all of this would be so drastic, or happen so fast. But here we are. The short-termism of university administrators, the instinct to ride it out, isn’t going to work. The Trump administration is going to run through us like a pack of wolves on a flock of sheep.""

a cartoon of homer simpson holding a card ALT: a cartoon of homer simpson holding a card

Bluetorial:

The announcement to move scientific review out of the institutes and centers into the Center for Scientific Review (CSR) and its potential consequences

1/10 🧠 We need better ways to measure brain excitability in psychiatric disorders. The prefrontal cortex—key target for brain stimulation treatments—is particularly hard to assess. Our new studies tackle this with systematic mapping! bit.ly/4cjHknX & bit.ly/3PW8RCx

The whole "$1 NIH dollar generates $2.50 in output" sells science wildly short. Scientific discovery and technological development is the foundation on which our entire society is built -- and that includes all the businesses that operate within it. The throughlines are shorter than you think: 1/n

What happens when you combine music and brain stim? 🎵⚡🧠
Our team found timing TMS pulses with music enhanced brain responses - an exciting potential pathway to improve stim effects. LOTS more to do!
Grateful to our village @stanfordmedicine.bsky.social 🙏. Esp the developer @jessicamross8.bsky.social

Hello BlueSky community! 🦋👋 We're the Stanford Precision Neurotherapeutics Lab 🧠

Dedicated to advancing neuroscience by deconstructing brain stimulation to build personalized treatments for mental health disorders 🚀

Check out our work and learn more about us!
🔗 precisionneuro.stanford.edu (1/2)

🚨 New preprint alert 🚨 Musical rhythms can boost brain stimulation effects! ⚡️ Sensory-entrained #TMS (seTMS) synchronizes TMS pulses with auditory rhythm-induced high-excitability brain states 🎶🧠

Thread below 👇 @stanfordmedicine.bsky.social #StanfordMed #StanfordBrain (1/10)

We're excited to share NaviNIBS, our new open-source tool 🔨 for neuronavigated noninvasive #brainstim 🧠⚡️

🎉Congrats to our co-director Chris Cline, lead developer of NaviNIBS!

We hope to enable new possibilities for innovations in neuronavigation #TMSEEG @stanfordmedicine.bsky.social (1/5)

Hoping to track research advances in neuromodulation on Bluesky through this starter pack: go.bsky.app/4LP6pxR

Please let me know if others should be added!