T-cell protrusions enable fast, localised initiation of chimeric antigen receptor signalling - The EMBO Journal Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in migration. Recent studies have uncovered their contribution to antigen surveillance and immune ...

Revised role for actin-rich protrusions in T-cell activation:
@franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components
link.springer.com/article/10.1...

a cartoon character with a bucket on his head is holding a shovel and talking to another cartoon character . Alt: a cartoon character with a bucket on his head is holding a shovel and talking to another cartoon character. It’s Bruno.

One thing my grants have in common with Bruno?

Not Discussed looooool

Drinking Culture Hi, My name is Georgia Kash and I am an 8th grader at dukeschool in durham which is a project based school, and for my final project I am studying the effect of mocktails on the society. A part of th...

My daughter has a capstone project (for 8th grade) on mocktails and how they have impacted drinking culture. She put together a survey for this project, if you are so inclined to take it, feel free:

docs.google.com/forms/d/e/1F...

some data on the shrinkage

👀 🧬

A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging

🤩 @bbparis1984.bsky.social

doi.org/10.64898/202...

Too Many Request screenshot when trying to unsubscribe from MDPI emails

lol try to unsubscribe from MDPI emails and this is what I get

Really thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals.

www.biorxiv.org/content/10.6...

STAT4-dependent regulation of neuroinflammation in atherosclerosis.

Cool preprint. myeloid-driven STAT4 in an atherosclerosis model increased neuronal death and neuroinflammation

doi.org/10.64898/202...

Unveiling the molecular architecture of T cells and immune synapses with cryo-expansion microscopy Cytotoxic T cell killing is executed at the immunological synapse, whose nanoscale organization underlies function but remains difficult to resolve in…

Unveiling the molecular architecture of T cells and immune synapses with cryo-expansion microscopy.

wow. really cool imaging here. especially if you like immune cells

www.sciencedirect.com/science/arti...

Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.

Nice paper in JCI on TBI and microglia in aging

doi.org/10.1172/JCI1...

Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy | PNAS Multiple system atrophy (MSA) is a progressive neurologic disease, known as an α-synucleinopathy. There are currently no effective disease-modifyin...

Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.

Cool paper on CD8 T cells and multiple system atrophy

doi.org/10.1073/pnas...

Systems biology of Alzheimer’s Disease: A scoping review of key pathways & mechanisms link.springer.com/epdf/10.1186... #alzheimers #brain #neurology

GZMH+ GZNK+ double positive CD8 T cells: EBV specific t cell expansion in cerebrospinal fluid of multiple sclerosis patients

GZMH+ GZNK+ double positive CD8 T cells: EBV specific t cell expansion in cerebrospinal fluid of multiple sclerosis patients

www.sciencedirect.com/science/arti...

How do we feel about PowerPoint suggestions? I’ve been leaning in hard

NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells Aging is accompanied by significant changes to the immune system. Allen et al. demonstrate that age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the emergence of pro-inflammatory Gzmk+ T cells. This work provides insight into the increased risk of inflammatory disease among the elderly.

Online now: NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells

Excited to share our #preprint showing that #macrophages in the regenerating #zebrafish #heart are shaped by local cardiac-immune microniches, with a fibroblast-to-macrophage signal promoting regeneration over fibrotic repair www.biorxiv.org/content/10.6...
@idrm.ox.ac.uk @oxforddpag.bsky.social

I tried to buy a scientific paper YouTube video by Christophe

Looking for a good introduction to the world of research paper mills? Check out this episode of Tunnel Vision (by Christophe Haubersin & team) doing a deep dive. Featuring myself, @jabyrnesci.bsky.social, Matt Spick and Ivan Oransky.

youtu.be/SEwiOykoXXc?...

Aging disrupts sympathetic innervation of the thymus @cp-cellreports.bsky.social @einsteinmededu.bsky.social @maryanovichlab.bsky.social
www.cell.com/cell-reports...

OMB always reviews agencies' plans for how they will spend their money before issuing apportionments.

But this year agencies didn't automatically get a portion of their funds right away once the spending bill was signed, as we reported last month. They had to wait till the review was complete.

National Library of Medicine and 24 other accounts | 11511545 Apportionment file 11511545 (National Library of Medicine and 24 other accounts) retrieved from OMB public records

OMB has posted the full-year apportionments for NIH.

openomb.org/file/11511545

I believe this means that NIH now has the spending authority to fund grants!

There may be nuances and I will be tracking these as best I can.

This is the apportionment (dated March 16th) that was mentioned by @delauro.house.gov and @maxkozlov.bsky.social from 2 days ago? From apportionment-public.max.gov

$47 billion

Doesn't seem to have a lot of footnotes.

Funding Blog Fiscal Year 2025 By the Numbers: Extramural Grant Investments in Research To promote transparency, each year we provide information about the NIH’s investments of taxpayer funds in extramural biomedical research and related activities. Today, we are sharing funding data for fiscal years (FYs) 2023 to 2025.

I wonder how it feels to be the NIH extramural nexus email person these days

Congratulations!!!

Good luck with the new endeavors!

screenshot of OMB circular pdf

screenshot of https://apportionment-public.max.gov/ 2026

just playing around with this. I don't see this NHLBI line in the JSON or Excel files. Is this part of the 'not very user friendly' part or am I just an ignoramus? also, I know you have other stuff going on, so feel free to tell me to buzz off if you don't have time for this

Q: You don’t regret that people might’ve lost important income to support their lives?

A: No, I think it was more important to reduce the federal deficit.

Q: Ok. Did you reduce the federal deficit?

A: No, we didn’t.

OpenOMB | Tracking apportionments just got easier OpenOMB is the easiest way to find and track apportionments. Apportionments are legally binding plans issued by the White House Office of Management and Budget that set the pace at which federal agenc...

They are! I recommend openomb.org bc the official site (apportionment-public.max.gov) isn't very user friendly. Note there's a 2 day lag between when apportionments are made to when they're posted.

Even still, it's pretty wonky to understand what the numbers mean. I'll keep posting about all this!

Hey Max, love the reporting you’ve been doing on this. Just curious if these notices are public?

Oof