Also in this boat, just here to say I feel you. And it feels like a constant dumpster fire... My trouble is more that I keep falling sick thanks to my little one. Similar overall outcomes though.
Image showing the paradigm for recording single neurons in a variety of brain regions in humans, while single-pulse TMS was applied to dlPFC. One subpanel shows that single neurons were able to be resolved very early (8ms) after the single-pulse stimulation. Another subpanel shows two example neuron waveforms, along with their inter-spike interval distributions. The final subpanels show spike density functions overlaid on raster plots for the same neuron, separately for active and sham stimulation, in order to demonstrate that active (but not sham) stimulation increased activity in this example neuron.
We have a new preprint examining single neuron responses in humans undergoing TMS (www.biorxiv.org/content/10.6...). The excellent Charlie Dickey led the way, and I had the privilege to co-supervise this work with @coreykeller.bsky.social and @aaronboes.bsky.social 🧵 (1/7) 🧠🟦 🧠💻
fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs)
But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995
🧵1/n
Snapshot of a figure from "Physiologically realistic gamma activity produced in silico by weakening the PING attractor state" showcasing a transient gamma event via a raster plot, firing rate histogram, and spectral analysis.
2/5 We studied sources of biophysical realism that have classically been viewed as "breaking" idealized in silico Pyramidal Interneuron Network Gamma rhythms. But these changes ALSO create transient gamma events that more closely mirror the in vivo reality of gamma activity!
The cognitive dissonance driven outcomes of this aren't going to be pretty.
This is terrific! Thanks for sharing :)
Wow I want to do this (to be fair I'm trying to anyway 😁)
I came to Minneapolis to report on what's going on, and one of the main questions I showed up with is "just what is the scale of the resistance?" After all, we're all used to the news calling Portland a "war zone" or whatever when it's just some protests in one part of town.
Here's what I put together after several more days on the ground there:
margaretkilljoy.substack.com/p/our-neighb...
If you're living somewhere outside the USA, one thing you can do is pressure your leaders to boycott World Cup and Olympic events here.
Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in the relationship between memory and prediction, and have a track record of neuroimaging/decoding? Please apply! #NeuroJobs
www.academictransfer.com/nl/jobs/3576...
5️⃣ The thalamus is for __________ learning?
Just to keep this going 😁
Nice! I would imagine that so long as there's limited driving noise, even waveform distortion (from filtering) won't affect an algorithm like this for burst detection - especially if rather than using just the median you ask for the IF dist to reflect the 1/f-normed PSD around the central freq.
Curious how this plays out for something that occurs as an AR(2) process as proposed for gamma… tends to have broader IF dist.
Also sleep EEG lit has ways to try and disambiguate bursts from non-bursts - esp. to find spindles which are right in that alpha range.
pubmed.ncbi.nlm.nih.gov/38650060/
New Preprint alert 🚨
“Inter-areal coupling for cognition through coincident oscillatory transients” together with
@ycaoneuro.bsky.social
@ktsetsos.bsky.social
@donnerlab.bsky.social &
Andreas Engel
#MEG #neuroscience #bioRxiv
www.biorxiv.org/content/10.1...
New Perspective from myself, Sarah Heilbronner and @myoo.bsky.social . “Rethinking the centrality of brain areas in understanding functional organization” in Nature Neuroscience. 🧵
rdcu.be/eVZ1A
🚨 What if evolution is the ”law”… and networks are the machines that do the work?
In this paper (just published) I try to formalize how living systems are non-equilibrium, information-processing, adaptive matter. With a great biological flavor! 🧪🌐🌍🧬🦠
👉 iopscience.iop.org/article/10.1...
🧵 1/
Whoaa
Good point!
Fascinating and ground breaking work. I don't think we've ever looked at sinle neuron activity in the human thalamus before.
A naive question from someone looking more at brain oscillations - why not build avoid binning entirely and use generalized linear models where phase can be continuously modeled? If you have a multimodal relationship to the behavior (I.e. Hit rate) you use harmonies. elifesciences.org/articles/44287
Please help me find the answer to this question by reposting or tagging people who might know. What is a proper #?
For e.g. for patients with epilepsy, stopping seizures stops both the dynamics and clinical symptoms. That's the most drastic example I can think of. (3/3)
Think of the canonical example of gamma produced by PING.
So when seen in that light, to me anyway, if we can change oscillations, then we change the overall attractor state of the circuit. If we can do that, then it's inevitable we change function.
(2/3)
These are all important and relevant points as well. As are others made in these and other threads about oscillations. But one line of thinking I find missing is that of seeing it all as a singular dynamical system.
Spiking networks produce activity that organizes in oscillatory bursts. (1/3)
Immediately a fan from reading the behavioral experiment included here to study the effect of psilocybin
This one looks intriguing. Arousal "embedding" whole-brain dynamics. 🤯
#neuroskyence #compneurosky
doi.org/10.1038/s415...
