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Posts by Dan Brierley

Was an honour and a pleasure to be able to contribute to this work by Will de Lartigue and @hjchoimd.bsky.social, who deserve credit for everything except satiation vs satiety pedantry, and all the Oxford commas.

Fantastic (and patient!) editorial support from @natrevgastrohep.nature.com team too

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The critical role of gut–brain signalling in eating behaviour and obesity - Nature Reviews Gastroenterology & Hepatology This Review outlines the role of gut–brain signalling in eating behaviour and obesity, highlighting gut-derived signals and cues relevant during eating phases. Underlying mechanisms of this gut–brain ...

Really pleased to share our review of evidence for the diverse roles of the #vagus in each phase of eating behaviour, and our thoughts on how dysfunctional vagal #interoception drives obesity pathogenesis.

Hope it provokes some thoughts, and many experiments!

🧠📈 🧪

www.nature.com/articles/s41...

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Annette Dolphin obituary Other lives: Neuroscientist whose research showed how individual molecules can affect neurological disorders

Obituary of Annette Dolphin @annieneuro.bsky.social written by her sister in The Guardian. www.theguardian.com/science/2026...

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Great opportunity for ECRs to present their Neuroendocrinology research - don't miss the abstract deadline!

📈🧠

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We have a Prof role advertised at UoR. I’m very happy to informally chat with anyone interested, just get in touch.

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📖 March JNE out!

🧬 Melanocortin-4 receptor regulation update
🔬 NET biomarker panels for diagnosis
🌫️ Air pollution+stress on prenatal social behaviour
⚡ Stress effects on hypothalamus
🏥 ENETS position on NET surgery

onlinelibrary.wiley....

[AI generated]

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Opinion | GLP-1 Experimentation Is Everywhere, and Science Can’t Keep Up (Gift Article) Millions of Americans are experimenting with the drugs. Science can’t keep up.

Terrific @nytimes.com piece on the new GLP-1s by my friend @juliabelluz.bsky.social.

They started as diabetes drugs, and are now used for weight loss, very successully.

But they offer promise for a HUGE range of diseases & conditions.

www.nytimes.com/interactive/...

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Delighted to share our discoveries about one of the brain's neurotransmitter systems:
www.biorxiv.org/content/10.6...

Together with colleagues at the @alleninstitute.org, we have learned a lot about a tiny cluster of neurons in the brainstem locus coeruleus (LC) that releases norepinephrine (NE). 1

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We're delighted Professor Gareth Leng Gareth Leng will be the plenary speaker at our ECR meeting #NeuroendoCelebrate2026 in Manchester this Sept.

Watch a recent interview with Gareth for what to expect: www.youtube.com/watc...

Join us: www.neuroendo.org.uk...+

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UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...

This meeting looks like its going to be bigger and better than 2024.

Come to Bristol in June for the chance to mingle with the glia glitterati of the United Kingdom

#neuroscience #glia #science #events #conference #networking

www.physoc.org/events/uk-gl...

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The Michael Harbuz Prize is a great opportunity for all our outstanding emerging neuroendocrinologists 🧠.

Winners get:

🔬30 min lecture at #NeuroendoCelebrate2026
🖋️JNE Early Career Perspective article
💸£750
🧡1yr BSN membership

Apply by 1.5.26: neuroendo.org.uk/pag...

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Ready to shine in the world of neuroendocrinology? 🌟

Apply for the Julia Buckingham Award, recognising the achievement & potential of ECRs.

Winners get:
🔬 15-min lecture at #NeuroendoCelebrate2026
💸 £375
🧡 1-year BSN membership

Apply by 1.5.26 www.neuroendo.org.uk...

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We haven't got any funds to fly people over unfortunately, but if you are visiting anyway at any point let me know, as we'd definitely love to have you give a seminar

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No SSIB this year unfortunately - giving the US a wide berth until further notice tbh

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Genetic predictors of GLP1 receptor agonist weight loss and side effects - Nature Identification of genetic variants associated with the efficacy and side effects of GLP1 medications could underpin development of precision medicine approaches in the treatment of obesity.

It really is. And that's before you get into genetic variation in GLP-1R and GIPR in humans... www.nature.com/articles/s41...

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I'm inclined to agree. Certainly nowhere near enough known about how brain penetrance of these drugs is influenced by which specific GLP1RAs tested (and if any conjugated labels), dosing frequency, dose time of day, obesity / inflammatory status etc.

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No apology needed - great to see some proper discussion on here still. Reminds me of the good old days in the Bad Place...

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Congrats Miguel, Andrew and team!

This one's going straight onto the journal club list...

Any evidence (or opinions) on whether this is a direct effect of Ex4 on the CeA GLP-1R neurons?

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Japan is calling - submit your late breaking abstract for the ICN2026!

The ICN is the premier meeting in neuroendocrinology and only happens once every four years. Be there! 😎🧠🌟

@infneuroendo.bsky.social @paneuroendo.bsky.social @bsneuroendo.bsky.social @sneuroendo.bsky.social

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Protect Academic Life in Iran We, the undersigned academics and researchers from around the world, express our profound concern over recent military strikes on Iran, the retaliatory responses, and the reported impact on civilian l...

Academic friends,
It's beyond heartbreaking to watch what's unfolding in Iran & the region.
A few of us drafted an open letter calling for protection of civilians & of educational, research, medical & cultural institutions.

Please read & sign if you agree:
sites.google.com/view/protect...

#IranWar

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Dose–response analysis of tirzepatide and acute pancreatitis: An international systematic review and quantitative meta-analysis of randomised trials Tirzepatide, a dual GIP/GLP-1 receptor agonist for type 2 diabetes and obesity, carries a theoretical risk of pancreatitis. Whether risk varies by dos…

GLP-1 medicines and #pancreatitis After 21 years, lots of smoke, no fire. Here a look at Tirzepatide www.sciencedirect.com/science/arti... www.google.com/imgres?q=pan...

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Are you planning a neuroendocrine meeting & need extra funds to run it/bring in a wider community, e.g. via travel grants?

Apply for the JNE Symposium grant for up to £5k at any time.

As part of the grant, recipients publish a JNE Special Issue.

www.neuroendo.org.uk...

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Wanna do neuroscience in Paris but can't find interesting lab?

Want to come do a sabbatical but don't know who to collaborate?

Check this webpage aggregating ~all the neuroscience labs (+200) in Paris.

⚠️only the information of 'verified' profiles is reliable⚠️

Please retweet 🙏

parisneuro.fr

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Career Opportunities Current vacancies in neuroendocrinology.

Career Opportunity:

PhD Project – Seeing the Invisible: Ultrasound Imaging of Metabolism in Living Animals at Imperial College London with Prof Kevin Murphy.

Deadline 20 April 2026

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👇 Super helpful resource for ECRs 👇

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NHS England to offer weight-loss drugs to 1.2m people to reduce risk of heart attacks and strokes People who are not obese but overweight and at risk of serious cardiovascular events eligible for weekly jabs

Nice to see this recommendation being put forward, based on "compelling" evidence from #UCL study showing protective effects of semaglutide on cardiovascular outcomes independent of weight loss.

Hope this signals the start of broader evidence-based prescription of GLP-1RAs on the NHS

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👇 Great advice! 👇

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Super excited to see the first paper from my PhD out! 🐭 Very satisfying to get to build an interpretable model of how the brain does a thing. A nice palette cleanser in the current sea of LLMs and deep ML.

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You've got 'anti-Fos' IHC working in NTS? Nice!

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Snake postprandial metabolite shows cross-species activation of hypothalamic neurons Nature Metabolism, Published online: 27 March 2026; doi:10.1038/s42255-026-01488-xBurmese pythons exhibit extreme feeding and fasting patterns, which might be underlain by extreme molecular responses. Untargeted metabolomics of python blood uncovers a conserved metabolite — para-tyramine-O-sulfate — whose levels spike after feeding and that activates hypothalamic neurons in both python and mouse.
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