Granzyme B-Targeting Quenched Activity-Based Probes for Assessing Tumor Response to Immunotherapy Molecular imaging of immune activation holds tremendous potential for the development of novel immunotherapies. In particular, chemical probes capable of detecting immune responses before changes in t...

Our work on developing a fluorescent probe to measure granzyme B activity in anti-tumor immunity is finally out! pubs.acs.org/doi/10.1021/...

Thanks, Mike!!

Chemical tools to define and manipulate interferon-inducible Ubl protease USP18 - Nature Communications USP18 is a multifunctional cysteine protease involved in IFN pathways. Here, the authors report chemical probes and chemoproteomics platforms that allow to detect and perturb USP18 activity in complex...

Happy to share our work published www.nature.com/articles/s41.... We describe the design of activity-based probes and chemoproteomic strategies to study USP18.

It was great to host @christhechang.bsky.social to CBL, NCI-Frederick. A wonderful seminar, a stimulating day full of new ideas! Thanks for the visit!