Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues - Nature Metabolism Analysing the causal links of gene expression and protein abundance on type 2 diabetes risk in blood and seven tissues related to the disease from individuals of four ancestries, the authors advance our understanding of the genetic architecture of type 2 diabetes

RESEARCH |

@ozvanbocher.bsky.social E Zeggini (U Brest, Helmholtz Munich) et al.

The causal links of gene expression and protein abundance on type 2 diabetes risk in 4 ancestries 🧪

Identifying genes and proteins with causal effects on type 2 diabetes risk across tissues and populations - Nature Metabolism Using tissue- and ancestry-aware causal inference analyses, we identified 923 genes and 46 proteins whose expression levels causally influence type 2 diabetes risk. Tissue-related heterogeneity was hi...

Very proud and happy to share the publication of our study in Nature Metabolism, where we decipher causal molecular mechanisms underlying Type 2 Diabetes 🥳🧬

Key insights from the study highlighted in the Research Briefing: www.nature.com/articles/s42...
Full study: www.nature.com/articles/s42...

Our study on causal molecular mechanisms leading to T2D is out as a preprint ! We highlight genes and proteins with putative causal effects, mostly shared across ancestries but with high tissue-related heterogeneity, offering targets for prioritization in future T2D research.

Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health - npj Metabolic Health and Disease npj Metabolic Health and Disease - Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health

New paper out! Impact of dietary restriction of animal products on molecular profiles, most of which are positive for health. Our findings can inform drug development in a food-as-medicine approach. Huge thanks to everyone involved and to the study's participants! www.nature.com/articles/s44...

So proud to have received an award for my PhD from #FondationUBO. Thank you again to @UBO_UnivBrest and to my supervisors @GeninEmmanuelle, @HydrePrever and @JF2leuze.
It has been an incredible adventure that I am delighted to pursue now at @HelmholtzMunich with @EleZeggini

Do you want to perform rare variants analysis in the whole genome and go beyond the genes ? Try out RAVA-FIRST, now published in @PLOSGenetics !

x.com/OzvanBocher/st… journals.plos.org/plosgenetics/a…

Such a nice conference at #IGES22 with amazing talks and the opportunity to present our on-going work, many thanks to the organisers!
@EleZeggini @Architex_97 @ArrudaAnaLuiza @GeorgiaKatsoul6 @grace_png @ynancy

RAVA-FIRST: our new strategy to study rare variants in the coding and the non-coding genome. Freely available in the R package Ravages.
@GeninEmmanuelle @HydrePrever @TregouetBPH @JF2leuze

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Very proud to have defended my PhD thesis yesterday at @UBO_UnivBrest. Many thanks to @GeninEmmanuelle, @HydrePrever and @JF2leuze for those three years and looking forward to start a new adventure in Munich with @EleZeggini team !

Un immense merci aux participants pour leur qualité de présentation, à toute l'équipe organisatrice de @STheizh et à @MathieuRouault. C'était une incroyable expérience !

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#ScienceEnTheizh c'est demain à 14 sur YouTube ! 🙂
#research #PhD #science

t.co/1By93e7ZVc

Merci au jury d'avoir accepté d'évaluer les travaux des doctorants lors du Pecha Kucha de #ScienceEnTheizh. Rdv Samedi sur YouTube ! 🙂

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Merci à @OuestFrance pour ce soutien. Rendez-vous samedi prochain sur YouTube ! 😁

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Brest | Science en Theizh Evénement de vulgarisation scientifique grand public Science en Theizh organisé par l'association des doctorants brestois : Dakodoc

Et pour reproduire les expériences chez vous, retrouvez le matériel sur le site! #ScienceEnTheizh

x.com/STheizh/status… scienceentheizh.fr

Merci à @ElyneDugeny !

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Our last work has just been published showing a gain in power of SKAT when subphenotypes of a disease are genetically heterogeneous

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Happy to share our review on rare variant association tests in the non coding genome !

link.springer.com/article/10.100…